Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 104 (08 May 2019)
Sequence version 1 (24 Jul 2007)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Slit homolog 1 (Drosophila)

Gene

SLIT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Slit homolog 1 (Drosophila)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLIT1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

SecretedSAAS annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35938

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500269853233 – 1534Sequence analysisAdd BLAST1502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi952 ↔ 961PROSITE-ProRule annotation
Disulfide bondi993 ↔ 1002PROSITE-ProRule annotation
Disulfide bondi1031 ↔ 1040PROSITE-ProRule annotation
Disulfide bondi1071 ↔ 1080PROSITE-ProRule annotation
Disulfide bondi1109 ↔ 1118PROSITE-ProRule annotation
Disulfide bondi1153 ↔ 1162PROSITE-ProRule annotation
Disulfide bondi1342 ↔ 1352PROSITE-ProRule annotation
Disulfide bondi1364 ↔ 1373PROSITE-ProRule annotation
Disulfide bondi1381 ↔ 1391PROSITE-ProRule annotation
Disulfide bondi1403 ↔ 1412PROSITE-ProRule annotation
Disulfide bondi1422 ↔ 1432PROSITE-ProRule annotation
Disulfide bondi1444 ↔ 1453PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A6H8V1

PRoteomics IDEntifications database

More...
PRIDEi
A6H8V1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6H8V1 HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini927 – 962EGF-likeInterPro annotationAdd BLAST36
Domaini964 – 1003EGF-likeInterPro annotationAdd BLAST40
Domaini1005 – 1041EGF-likeInterPro annotationAdd BLAST37
Domaini1043 – 1081EGF-likeInterPro annotationAdd BLAST39
Domaini1083 – 1119EGF-likeInterPro annotationAdd BLAST37
Domaini1127 – 1163EGF-likeInterPro annotationAdd BLAST37
Domaini1166 – 1339LAM_G_DOMAINInterPro annotationAdd BLAST174
Domaini1340 – 1374EGF-likeInterPro annotationAdd BLAST35
Domaini1377 – 1413EGF-likeInterPro annotationAdd BLAST37
Domaini1418 – 1454EGF-likeInterPro annotationAdd BLAST37
Domaini1459 – 1534CTCKInterPro annotationAdd BLAST76

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4237 Eukaryota
COG4886 LUCA

KEGG Orthology (KO)

More...
KOi
K06838

Database of Orthologous Groups

More...
OrthoDBi
28488at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF02210 Laminin_G_2, 1 hit
PF13855 LRR_8, 6 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SM00274 FOLN, 4 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 18 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 8 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 21 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6H8V1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT
60 70 80 90 100
GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGVV
110 120 130 140 150
ERGAFDDMKE LERLRLNRNQ LHMLPELLFQ NNQALSRLDL SENAIQAIPR
160 170 180 190 200
KAFRGATDLK NLQLDKNQIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS
210 220 230 240 250
FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG
260 270 280 290 300
LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL
310 320 330 340 350
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP
360 370 380 390 400
DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA
410 420 430 440 450
FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL
460 470 480 490 500
ADFLRTNPIE TSGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED
510 520 530 540 550
YQLNSECNSD VVCPHKCRCE ANVVECSSLK LTKIPERIPQ STAELRLNNN
560 570 580 590 600
EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS VSELHLTANQ
610 620 630 640 650
LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT
660 670 680 690 700
TVSPGAFDTL QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN
710 720 730 740 750
PDFLRQIPLQ DVAFPDFRCE EGQEEGGCLP RPQCPQECAC LDTVVRCSNK
760 770 780 790 800
HLRALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS
810 820 830 840 850
NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDISTLQEG
860 870 880 890 900
IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPQDME
910 920 930 940 950
GKLLLTTPAK KFECQGPPTL AVQAKCDLCL SSPCQNQGTC HNDPLEVYRC
960 970 980 990 1000
ACPSGYKGRD CEVSLDSCSS GPCENGGTCH AQEGEDAPFT CSCPTGFEGP
1010 1020 1030 1040 1050
TCGVNTDDCV DHACANGGVC VDGVGNYTCQ CPLQYEGKAC EQLVDLCSPD
1060 1070 1080 1090 1100
LNPCQHEAQC VGTPDGPRCE CMPGYAGDNC SENQDDCRDH RCQNGAQCMD
1110 1120 1130 1140 1150
EVNSYSCLCA EGYSGQLCEI PPHLPAPKSP CEGTECQNGA NCVDQGNRPV
1160 1170 1180 1190 1200
CQCLPGFGGP ECEKLLSVNF VDRDTYLQFT DLQNWPRANI TLQVSTAEDN
1210 1220 1230 1240 1250
GILLYNGDND HIAVELYQGH VRVSYDPGSY PSSAIYSAET INDGQFHTVE
1260 1270 1280 1290 1300
LVAFDQMVNL SIDGGSPMTM DNFGKHYTLN SEAPLYVGGM PVDVNSAAFR
1310 1320 1330 1340 1350
LWQILNGTGF HGCIRNLYIN NELQDFTKTQ MKPGVVPGCE PCRKLYCLHG
1360 1370 1380 1390 1400
ICQPNATPGP MCHCEAGWVG LHCDQPADGP CHGHKCVHGQ CVPLDALSYS
1410 1420 1430 1440 1450
CQCQDGYSGA LCNQAGALAE PCRGLQCLHG HCQASGTKGA HCVCDPGFSG
1460 1470 1480 1490 1500
ELCEQESECR GDPVRDFHQV QRGYAICQTT RPLSWVECRG SCPGQGCCQG
1510 1520 1530
LRLKRRKFTF ECSDGTSFAE EVEKPTKCGC ALCA
Length:1,534
Mass (Da):167,954
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EDBF858F2C57BC2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC146761 mRNA Translation: AAI46762.1

NCBI Reference Sequences

More...
RefSeqi
NP_003052.2, NM_003061.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6585

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6585

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146761 mRNA Translation: AAI46762.1
RefSeqiNP_003052.2, NM_003061.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA6H8V1
PRIDEiA6H8V1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6585
KEGGihsa:6585

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6585
PharmGKBiPA35938

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
KOiK06838
OrthoDBi28488at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLIT1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6585

Gene expression databases

GenevisibleiA6H8V1 HS

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF02210 Laminin_G_2, 1 hit
PF13855 LRR_8, 6 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 4 hits
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SM00274 FOLN, 4 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 18 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 8 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 21 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6H8V1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6H8V1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 8, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again