UniProtKB - A6H8M9 (CDHR4_HUMAN)
Protein
Cadherin-related family member 4
Gene
CDHR4
Organism
Homo sapiens (Human)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).By similarity
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | A6H8M9 |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-related family member 4Alternative name(s): Cadherin-like protein 29 |
Gene namesi | Name:CDHR4 Synonyms:CDH29 ORF Names:UNQ9392/PRO34300 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:34527, CDHR4 |
neXtProti | NX_A6H8M9 |
VEuPathDBi | HostDB:ENSG00000187492.8 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 17 – 686 | ExtracellularSequence analysisAdd BLAST | 670 | |
Transmembranei | 687 – 707 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 708 – 788 | CytoplasmicSequence analysisAdd BLAST | 81 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 389118 |
OpenTargetsi | ENSG00000187492 |
PharmGKBi | PA165696944 |
Miscellaneous databases
Pharosi | A6H8M9, Tdark |
Genetic variation databases
BioMutai | CDHR4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000319973 | 17 – 788 | Cadherin-related family member 4Add BLAST | 772 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 242 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | A6H8M9 |
PaxDbi | A6H8M9 |
PeptideAtlasi | A6H8M9 |
PRIDEi | A6H8M9 |
ProteomicsDBi | 775 [A6H8M9-1] 776 [A6H8M9-2] |
PTM databases
GlyGeni | A6H8M9, 1 site |
iPTMneti | A6H8M9 |
PhosphoSitePlusi | A6H8M9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187492, Expressed in right uterine tube and 83 other tissues |
ExpressionAtlasi | A6H8M9, baseline and differential |
Organism-specific databases
HPAi | ENSG00000187492, Tissue enhanced (epididymis, fallopian tube) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000391409 |
Miscellaneous databases
RNActi | A6H8M9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 237 – 338 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 339 – 449 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 444 – 554 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 551 – 674 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 124 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1219, Eukaryota |
GeneTreei | ENSGT00940000162824 |
HOGENOMi | CLU_382923_0_0_1 |
InParanoidi | A6H8M9 |
OMAi | APRMEMP |
OrthoDBi | 371149at2759 |
PhylomeDBi | A6H8M9 |
TreeFami | TF341878 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS |
Pfami | View protein in Pfam PF00028, Cadherin, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 2 hits |
SUPFAMi | SSF49313, SSF49313, 4 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 1 hit PS50268, CADHERIN_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A6H8M9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVLLRLLVFL FAPVVSDLCS LPCFINVSES QGPGTVLQFL SFNCSSYTPT
60 70 80 90 100
PTLELLNVQP PTTFFNPPSL ARWQGTYVGK LTLSSSAQLD ALMVNHYKVQ
110 120 130 140 150
LKFTCGNHVM EGSLSVDVQR DLSHIQCAGQ FASPAGEMIQ VPETVTPGAR
160 170 180 190 200
LYTLLLPGLE LHGAQMSIIS AQDLPHFPGP FSINEQGWLQ APSQGLLGQA
210 220 230 240 250
QKVFQLQISV SFGQRQSCQG MVIVKVLPVP SSQVSFLEQA QNITIPENLA
260 270 280 290 300
PGSEVVQVQA RGVDLRYEIL SPVPSPLFSI GRADGVVRTT TPLELARTSG
310 320 330 340 350
TAVSRLQVKA FEQGQLWASA KLNLTMNVQL VNLWPPRCLP ALLVSQIPET
360 370 380 390 400
APVGTVLNTL TCEDPDSVGA TLDYKLWFRS SSNPASLCLY DRVLEVNATL
410 420 430 440 450
DCDTPGACFQ HAASILVLDG GQPQMTTEVP VLVMVTPINE FSPACAPRTF
460 470 480 490 500
RVQEDAAPHT LLGSVVGTDM DYPHDNIEYY TSGGPTTFAV DRLSGEVHLL
510 520 530 540 550
GPLDYEQQRL YRLTVLVIDH GQDQNPNHHL SGSCTITIEV EDVNDHAPEC
560 570 580 590 600
EPPFQELTIY APLGRSVEVT KMSCQIPQEP QRLIYSYSIV GGNSQNRFIL
610 620 630 640 650
QGAILVHSDL VLGPFWPEQP RTYELLICVA DAGPSTPHLS TTATIIVHLV
660 670 680 690 700
PRRASTVATS THRTTVPSTM TPMLVTDTEA FWQPQPWFVV VLTATGALLL
710 720 730 740 750
LALGWLLGRL LQGLAQLLQA PSKPAQALLL NSIQGTEGSI EGFLEAPKME
760 770 780
MSQAPSSVMS LHFDGRAQDS RTGRDYLFNT HTGARRWL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C4N6 | H7C4N6_HUMAN | Cadherin-related family member 4 | CDHR4 | 134 | Annotation score: | ||
H7C5B2 | H7C5B2_HUMAN | Cadherin-related family member 4 | CDHR4 | 151 | Annotation score: | ||
E9PFE8 | E9PFE8_HUMAN | Cadherin-related family member 4 | CDHR4 | 184 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039109 | 5 | R → K. Corresponds to variant dbSNP:rs13072748Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031552 | 135 | A → GEARGSRQGGGRHGLSRSSL TSTLASWGNDSGARDSHTWG SAVHSAPPRPRTPRSAGKPR TWDGG in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_031553 | 136 – 788 | Missing in isoform 2. 2 PublicationsAdd BLAST | 653 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358221 mRNA Translation: AAQ88588.1 BC132756 mRNA Translation: AAI32757.1 BC146674 mRNA Translation: AAI46675.1 |
CCDSi | CCDS46829.1 [A6H8M9-1] |
RefSeqi | NP_001007541.2, NM_001007540.3 [A6H8M9-1] |
Genome annotation databases
Ensembli | ENST00000343366; ENSP00000341302; ENSG00000187492 [A6H8M9-2] ENST00000412678; ENSP00000391409; ENSG00000187492 [A6H8M9-1] |
GeneIDi | 389118 |
KEGGi | hsa:389118 |
UCSCi | uc003cxp.3, human [A6H8M9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358221 mRNA Translation: AAQ88588.1 BC132756 mRNA Translation: AAI32757.1 BC146674 mRNA Translation: AAI46675.1 |
CCDSi | CCDS46829.1 [A6H8M9-1] |
RefSeqi | NP_001007541.2, NM_001007540.3 [A6H8M9-1] |
3D structure databases
SMRi | A6H8M9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000391409 |
PTM databases
GlyGeni | A6H8M9, 1 site |
iPTMneti | A6H8M9 |
PhosphoSitePlusi | A6H8M9 |
Genetic variation databases
BioMutai | CDHR4 |
Proteomic databases
MassIVEi | A6H8M9 |
PaxDbi | A6H8M9 |
PeptideAtlasi | A6H8M9 |
PRIDEi | A6H8M9 |
ProteomicsDBi | 775 [A6H8M9-1] 776 [A6H8M9-2] |
Protocols and materials databases
Antibodypediai | 49593, 25 antibodies |
DNASUi | 389118 |
Genome annotation databases
Ensembli | ENST00000343366; ENSP00000341302; ENSG00000187492 [A6H8M9-2] ENST00000412678; ENSP00000391409; ENSG00000187492 [A6H8M9-1] |
GeneIDi | 389118 |
KEGGi | hsa:389118 |
UCSCi | uc003cxp.3, human [A6H8M9-1] |
Organism-specific databases
CTDi | 389118 |
DisGeNETi | 389118 |
GeneCardsi | CDHR4 |
HGNCi | HGNC:34527, CDHR4 |
HPAi | ENSG00000187492, Tissue enhanced (epididymis, fallopian tube) |
neXtProti | NX_A6H8M9 |
OpenTargetsi | ENSG00000187492 |
PharmGKBi | PA165696944 |
VEuPathDBi | HostDB:ENSG00000187492.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1219, Eukaryota |
GeneTreei | ENSGT00940000162824 |
HOGENOMi | CLU_382923_0_0_1 |
InParanoidi | A6H8M9 |
OMAi | APRMEMP |
OrthoDBi | 371149at2759 |
PhylomeDBi | A6H8M9 |
TreeFami | TF341878 |
Enzyme and pathway databases
PathwayCommonsi | A6H8M9 |
Miscellaneous databases
BioGRID-ORCSi | 389118, 4 hits in 876 CRISPR screens |
GenomeRNAii | 389118 |
Pharosi | A6H8M9, Tdark |
PROi | PR:A6H8M9 |
RNActi | A6H8M9, protein |
Gene expression databases
Bgeei | ENSG00000187492, Expressed in right uterine tube and 83 other tissues |
ExpressionAtlasi | A6H8M9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS |
Pfami | View protein in Pfam PF00028, Cadherin, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 2 hits |
SUPFAMi | SSF49313, SSF49313, 4 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 1 hit PS50268, CADHERIN_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDHR4_HUMAN | |
Accessioni | A6H8M9Primary (citable) accession number: A6H8M9 Secondary accession number(s): Q6UXT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 10, 2021 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants