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Entry version 79 (16 Jan 2019)
Sequence version 1 (24 Jul 2007)
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Protein

DENN domain-containing protein 4C

Gene

Dennd4c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • cellular response to insulin stimulus Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein transport Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 4C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dennd4c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914769 Dennd4c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004204461 – 1906DENN domain-containing protein 4CAdd BLAST1906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei702PhosphoserineBy similarity1
Modified residuei736PhosphoserineBy similarity1
Modified residuei740PhosphoserineCombined sources1
Modified residuei966PhosphothreonineCombined sources1
Modified residuei971PhosphoserineCombined sources1
Modified residuei973PhosphothreonineBy similarity1
Modified residuei987PhosphoserineCombined sources1
Modified residuei1000PhosphoserineBy similarity1
Modified residuei1043Phosphoserine1 Publication1
Modified residuei1058PhosphoserineBy similarity1
Modified residuei1096PhosphoserineCombined sources1 Publication1
Modified residuei1123PhosphoserineBy similarity1
Modified residuei1181PhosphoserineBy similarity1
Modified residuei1221PhosphoserineBy similarity1
Modified residuei1240PhosphoserineBy similarity1
Modified residuei1248PhosphoserineCombined sources1
Modified residuei1274PhosphoserineBy similarity1
Modified residuei1321Phosphoserine1 Publication1
Modified residuei1333PhosphoserineBy similarity1
Modified residuei1342PhosphoserineBy similarity1
Modified residuei1620PhosphoserineBy similarity1
Modified residuei1624PhosphoserineBy similarity1
Modified residuei1626PhosphoserineBy similarity1
Modified residuei1637PhosphoserineCombined sources1
Modified residuei1796PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to insulin.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6H8H2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A6H8H2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6H8H2

PRoteomics IDEntifications database

More...
PRIDEi
A6H8H2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6H8H2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6H8H2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038024 Expressed in 282 organ(s), highest expression level in islet of Langerhans

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6H8H2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6H8H2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039860

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6H8H2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 199MABPPROSITE-ProRule annotationAdd BLAST160
Domaini191 – 363uDENNPROSITE-ProRule annotationAdd BLAST173
Domaini384 – 520cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini522 – 640dDENNPROSITE-ProRule annotationAdd BLAST119
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati818 – 852PPRAdd BLAST35

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2127 Eukaryota
ENOG410XQMX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158215

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231590

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058313

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6H8H2

KEGG Orthology (KO)

More...
KOi
K20163

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMKQAAN

Database of Orthologous Groups

More...
OrthoDBi
75304at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR023341 MABP
IPR011990 TPR-like_helical_dom_sf
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit
PS51498 MABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A6H8H2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEDKGPRVT DYFVVAGLTD TSTLLDQEIN RTDTNSIGPK APITDIAVII
60 70 80 90 100
KSAGETVPEG YTCVEATPSA LQANLNYGSL KSPELFLCYR RGRDKPPLTD
110 120 130 140 150
IGVLYEGKER LMPGCEVIQA TPYGRCANVN NSSTTSQRIF ITYRRAPPVR
160 170 180 190 200
SQNSLAVTDI CVIITSKGET PPHTFCKVDK NLNCGMWGSN VFLCYKKSVP
210 220 230 240 250
ASNAIAYKAG LIFRYPEEDY ESFPLSPSVP LFCLPMGATI ECWDPQIKYP
260 270 280 290 300
LPVFSTFVLT GSSAEKVYGA AIQFYEPYSQ ERLTEKQLTQ LGLLTLVEKR
310 320 330 340 350
VVSKPINSNK CICLLSHWPF FEAFKNFLMF IYKVSVSGPH PLPIEKHISH
360 370 380 390 400
FMQNIPFPSP QRPRILIQLS VHDAFILSQP VSTPLPLSGA NFSSLLMNLG
410 420 430 440 450
PENCATLLLL VLLESKILLH SLRPAVLTGV AEAVVAMIFP FQWQCPYIPL
460 470 480 490 500
CPLSLAGVLS APLPFIVGVD SRYFDLHDPP QDVVCIDLDT NTLYVADERK
510 520 530 540 550
NINWKQLPKR PCKSLLGTLR RLYQQLCSVH RKPQESSAIE MTPIEADYSW
560 570 580 590 600
QKKMTQLEME IQETFLRFMA SILKGYRSYL RPITEAPSNK ATAADSLFDR
610 620 630 640 650
QGFLKSRDRA YTKFYTLLSK TQIFIRFIEE CSFVSDKDTG LAFFDDCIEK
660 670 680 690 700
LFPDKGVERT EKVDLDSAED TRLIELDDSQ RSEHTVFIMP PEPPPDDGNN
710 720 730 740 750
LSPQYSYTYF PRLDLKLFDS PQKLKLCFNR HPPGSSITNS PALMAKRTKQ
760 770 780 790 800
EIKTAHKLAK RCYTNPPQWA KYLFSHCYSL WFICLPAYVR VSHPKVRALQ
810 820 830 840 850
QAHDVLVKMR KTDVDPLDEV CYRVVMQLCG LWVNPVLAVR VLFEMKTARI
860 870 880 890 900
KPNAITYGYY NKVVLESPWP SSTRSGIFLW TKVRNVVHGL AQFRQPLKKT
910 920 930 940 950
GQKSQVFSIS GGQSDQGYGS KDELVKEGAD GHAPEEHTPP ELTTTELHIE
960 970 980 990 1000
EECDISAIVS KHLQPTPEPQ SPTEPPAWGS SIVKVPSGLF DTNNRTSTGS
1010 1020 1030 1040 1050
TSTVLFSTQA PVEDAVFSEV TNFKKNGDRG EKKQKHFPER SCSFSSESRA
1060 1070 1080 1090 1100
GMLLKKSSLD LNSSEMAIMM GADAKILTAA LTCPKTSPPH VTRTHSFENV
1110 1120 1130 1140 1150
NCHLADSRTR MSEGTRDSEH RSSPVLEMLE ESQELLEPVV GDNVAETAAE
1160 1170 1180 1190 1200
MTCNSLQSNS HSDQSRDTQA GAQDPVNKRS SSYATRKAIE REDVETGLDP
1210 1220 1230 1240 1250
LSLLATECVE KTSDSEDKLF SPVISRNLAD EIESYMNLKS PLGSKSCSME
1260 1270 1280 1290 1300
LHGEGNQEPG SPAVFAHPLE RSSSLPSDRG PPARDSTETE KSSPAVSSSK
1310 1320 1330 1340 1350
TLTGRFKPQS PYRAYKDRST SLSALVRSSP NSSLGSVVNS LSGLKLDNIL
1360 1370 1380 1390 1400
SGPKIDVLKS SMKQAATVAS KMWVAVASAY SYSDDEEETN KDYSFPAGLE
1410 1420 1430 1440 1450
DHHIVGETLS PNTSVSGLVP SELTQSNTSL GSSSSSGDVG KLQCPAGEVP
1460 1470 1480 1490 1500
FSRNIKGQDF EKSDHGSSQN TSMSSIYQNC AMEVLMSSCS QCRACGALVY
1510 1520 1530 1540 1550
DEEIMAGWTA DDSNLNTTCP FCKSNFLPLL NVEFKDLRGS ASFFLKPSTS
1560 1570 1580 1590 1600
GDSLQSGSIP SASEPSEHKP TSSSAEPDLI SFMDFSKHSE TITEEASYTV
1610 1620 1630 1640 1650
ESSDEIKKTN GDVQSVKMSS VPNSLSKRNV SLTRSHSVGG PLQNIDFSQR
1660 1670 1680 1690 1700
PFHGVSTVSL PSSLQEDVDH LGKRPSPPPV SVPYLSPLVL RKELESLLEN
1710 1720 1730 1740 1750
EGDQVIHTSS FINQHPIIFW NLVWYFRRLD LPSNLPGLIL TSEHCNGGVQ
1760 1770 1780 1790 1800
LPLSSLSQDS KLVYIQLLWD NINLHQEPGE PLYVSWRNLN SEKKPSLLSE
1810 1820 1830 1840 1850
QQQAASALVE TIRQSIQQND VLKPINLLSQ QMKPGTKRQR SLYREILFLS
1860 1870 1880 1890 1900
LVSLGRENID IEAFDNEYGL AYRSLPSESL ERLQRIDAPP SISVEWCRKC

FGAPLI
Length:1,906
Mass (Da):211,458
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i705904CB0F5BED64
GO
Isoform 2 (identifier: A6H8H2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     910-910: S → SAPQNAACGSDGDTVSHGSVDSSNDANNGEHTVFVRDLISLDSIDNHSST

Show »
Length:1,955
Mass (Da):216,455
Checksum:i3D97B5B382949DFF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q449E9Q449_MOUSE
DENN domain-containing protein 4C
Dennd4c
1,615Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044491910S → SAPQNAACGSDGDTVSHGSV DSSNDANNGEHTVFVRDLIS LDSIDNHSST in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL772228, BX005084 Genomic DNA Translation: CAM18278.1
BX005084, AL772228 Genomic DNA Translation: CAM27931.1
BC146602 mRNA Translation: AAI46603.1
AK155220 mRNA Translation: BAE33131.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51218.2 [A6H8H2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_908976.1, NM_184088.1 [A6H8H2-1]
XP_006538085.1, XM_006538022.2 [A6H8H2-2]
XP_006538086.1, XM_006538023.3 [A6H8H2-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.273718
Mm.472357

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000082026; ENSMUSP00000080685; ENSMUSG00000038024 [A6H8H2-2]
ENSMUST00000142837; ENSMUSP00000123367; ENSMUSG00000038024 [A6H8H2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
329877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:329877

UCSC genome browser

More...
UCSCi
uc008tmb.2 mouse [A6H8H2-1]
uc008tmc.1 mouse [A6H8H2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772228, BX005084 Genomic DNA Translation: CAM18278.1
BX005084, AL772228 Genomic DNA Translation: CAM27931.1
BC146602 mRNA Translation: AAI46603.1
AK155220 mRNA Translation: BAE33131.1
CCDSiCCDS51218.2 [A6H8H2-1]
RefSeqiNP_908976.1, NM_184088.1 [A6H8H2-1]
XP_006538085.1, XM_006538022.2 [A6H8H2-2]
XP_006538086.1, XM_006538023.3 [A6H8H2-2]
UniGeneiMm.273718
Mm.472357

3D structure databases

SMRiA6H8H2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039860

PTM databases

iPTMnetiA6H8H2
PhosphoSitePlusiA6H8H2

Proteomic databases

jPOSTiA6H8H2
MaxQBiA6H8H2
PaxDbiA6H8H2
PRIDEiA6H8H2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082026; ENSMUSP00000080685; ENSMUSG00000038024 [A6H8H2-2]
ENSMUST00000142837; ENSMUSP00000123367; ENSMUSG00000038024 [A6H8H2-1]
GeneIDi329877
KEGGimmu:329877
UCSCiuc008tmb.2 mouse [A6H8H2-1]
uc008tmc.1 mouse [A6H8H2-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55667
MGIiMGI:1914769 Dennd4c

Phylogenomic databases

eggNOGiKOG2127 Eukaryota
ENOG410XQMX LUCA
GeneTreeiENSGT00940000158215
HOGENOMiHOG000231590
HOVERGENiHBG058313
InParanoidiA6H8H2
KOiK20163
OMAiGMKQAAN
OrthoDBi75304at2759
TreeFamiTF313237

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

Protein Ontology

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PROi
PR:A6H8H2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000038024 Expressed in 282 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiA6H8H2 baseline and differential
GenevisibleiA6H8H2 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR023341 MABP
IPR011990 TPR-like_helical_dom_sf
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
PS51498 MABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN4C_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6H8H2
Secondary accession number(s): A2AJX5, Q3U2K9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: July 24, 2007
Last modified: January 16, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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