Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Active regulator of SIRT1

Gene

RPS19BP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity).By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-BTA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Active regulator of SIRT1
Alternative name(s):
40S ribosomal protein S19-binding protein 1
Short name:
RPS19-binding protein 1
Short name:
S19BP
Gene namesi
Name:RPS19BP1
Synonyms:AROS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:34132 RPS19BP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003615371 – 137Active regulator of SIRT1Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7CitrullineBy similarity1
Modified residuei84PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

PaxDbiA6H7J2

Expressioni

Gene expression databases

BgeeiENSBTAG00000017463 Expressed in 10 organ(s), highest expression level in colon

Interactioni

Subunit structurei

Interacts with RPS19. Interacts with SIRT1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023214

Family & Domainsi

Sequence similaritiesi

Belongs to the AROS family.Curated

Phylogenomic databases

eggNOGiENOG410J1DB Eukaryota
ENOG41126PZ LUCA
GeneTreeiENSGT00390000016774
HOGENOMiHOG000034068
HOVERGENiHBG097440
InParanoidiA6H7J2
OMAiQGRKACD
OrthoDBiEOG091G0YGT
TreeFamiTF333429

Family and domain databases

InterProiView protein in InterPro
IPR023262 AROS
PANTHERiPTHR31454 PTHR31454, 1 hit
PfamiView protein in Pfam
PF15684 AROS, 1 hit
PRINTSiPR02029 ACTREGSIRT1

Sequencei

Sequence statusi: Complete.

A6H7J2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAALLRRGL ELLGAPEAPG AAPGHTKPSQ APMKRTRKAK ATQAQKLRNS
60 70 80 90 100
AKGKVPKSAL AEFRKKERRG YLGVNLRFMT SARSTVDESV TRQIMRQNRG
110 120 130
RKACDRPVTK TKKKKKAEGT VFTEEDFQKF QREYFGS
Length:137
Mass (Da):15,367
Last modified:July 24, 2007 - v1
Checksum:i4959D30D90B154A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146267 mRNA Translation: AAI46268.1
RefSeqiNP_001092386.1, NM_001098916.2
UniGeneiBt.3077

Genome annotation databases

EnsembliENSBTAT00000023214; ENSBTAP00000023214; ENSBTAG00000017463
GeneIDi509108
KEGGibta:509108

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146267 mRNA Translation: AAI46268.1
RefSeqiNP_001092386.1, NM_001098916.2
UniGeneiBt.3077

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023214

Proteomic databases

PaxDbiA6H7J2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023214; ENSBTAP00000023214; ENSBTAG00000017463
GeneIDi509108
KEGGibta:509108

Organism-specific databases

CTDi91582
VGNCiVGNC:34132 RPS19BP1

Phylogenomic databases

eggNOGiENOG410J1DB Eukaryota
ENOG41126PZ LUCA
GeneTreeiENSGT00390000016774
HOGENOMiHOG000034068
HOVERGENiHBG097440
InParanoidiA6H7J2
OMAiQGRKACD
OrthoDBiEOG091G0YGT
TreeFamiTF333429

Enzyme and pathway databases

ReactomeiR-BTA-3371453 Regulation of HSF1-mediated heat shock response

Gene expression databases

BgeeiENSBTAG00000017463 Expressed in 10 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR023262 AROS
PANTHERiPTHR31454 PTHR31454, 1 hit
PfamiView protein in Pfam
PF15684 AROS, 1 hit
PRINTSiPR02029 ACTREGSIRT1
ProtoNetiSearch...

Entry informationi

Entry nameiAROS_BOVIN
AccessioniPrimary (citable) accession number: A6H7J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again