UniProtKB - A6H7C9 (CEP19_BOVIN)
Protein
Centrosomal protein of 19 kDa
Gene
CEP19
Organism
Bos taurus (Bovine)
Status
Functioni
Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes.By similarity
GO - Biological processi
- cilium assembly Source: UniProtKB
- microtubule anchoring at centrosome Source: UniProtKB
- vesicle targeting, trans-Golgi to periciliary membrane compartment Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Centrosomal protein of 19 kDaShort name: Cep19 |
Gene namesi | Name:CEP19 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:27198, CEP19 |
Subcellular locationi
Cytoskeleton
- centriole By similarity
- spindle pole By similarity
- cilium basal body By similarity
Note: Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase. Localizes slightly apical to the subdistal appendage on the mother centriole, but below the distal appendage.By similarity
Cytoskeleton
- centriole Source: UniProtKB
- centrosome Source: GO_Central
- ciliary basal body Source: UniProtKB
- spindle pole Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000360405 | 1 – 163 | Centrosomal protein of 19 kDaAdd BLAST | 163 |
Proteomic databases
PaxDbi | A6H7C9 |
PRIDEi | A6H7C9 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000013192, Expressed in brain and 19 other tissues |
Interactioni
Subunit structurei
Interacts with CEP43; this interaction is required for its localization to the mother centriole.
Interacts (via residues 121-150) with RABL2B.
Interacts (via C-terminus) with CEP350; this interaction is required for its localization to the mother centriole.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000017558 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CEP19 family.Curated
Phylogenomic databases
eggNOGi | ENOG502RZP1, Eukaryota |
GeneTreei | ENSGT00390000016356 |
HOGENOMi | CLU_113348_0_0_1 |
InParanoidi | A6H7C9 |
OMAi | CSWDEES |
OrthoDBi | 1594443at2759 |
TreeFami | TF328425 |
Family and domain databases
InterProi | View protein in InterPro IPR029412, CEP19 |
PANTHERi | PTHR31539, PTHR31539, 2 hits |
Pfami | View protein in Pfam PF14933, CEP19, 1 hit |
i Sequence
Sequence statusi: Complete.
A6H7C9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMCTAKKCGI RFQPPAIILI YENEIKGKSR QRIMPVRNFS KYSDCSRAAE
60 70 80 90 100
QLKNNPRHKG YLEQVSLKQL EKLFSFLRGN LWGQSLAETM EQIQRETTID
110 120 130 140 150
PEEDLNKLDD KELAKRKSIM DELFEKNQKK KDDPNFVYDI EVEFPQDEQL
160
QSCGWDTESA EEF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC146199 mRNA Translation: AAI46200.1 |
RefSeqi | NP_001092599.1, NM_001099129.1 XP_005201596.1, XM_005201539.3 XP_005201597.1, XM_005201540.3 |
Genome annotation databases
Ensembli | ENSBTAT00000017558; ENSBTAP00000017558; ENSBTAG00000013192 |
GeneIDi | 613916 |
KEGGi | bta:613916 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC146199 mRNA Translation: AAI46200.1 |
RefSeqi | NP_001092599.1, NM_001099129.1 XP_005201596.1, XM_005201539.3 XP_005201597.1, XM_005201540.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000017558 |
Proteomic databases
PaxDbi | A6H7C9 |
PRIDEi | A6H7C9 |
Genome annotation databases
Ensembli | ENSBTAT00000017558; ENSBTAP00000017558; ENSBTAG00000013192 |
GeneIDi | 613916 |
KEGGi | bta:613916 |
Organism-specific databases
CTDi | 84984 |
VGNCi | VGNC:27198, CEP19 |
Phylogenomic databases
eggNOGi | ENOG502RZP1, Eukaryota |
GeneTreei | ENSGT00390000016356 |
HOGENOMi | CLU_113348_0_0_1 |
InParanoidi | A6H7C9 |
OMAi | CSWDEES |
OrthoDBi | 1594443at2759 |
TreeFami | TF328425 |
Gene expression databases
Bgeei | ENSBTAG00000013192, Expressed in brain and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029412, CEP19 |
PANTHERi | PTHR31539, PTHR31539, 2 hits |
Pfami | View protein in Pfam PF14933, CEP19, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEP19_BOVIN | |
Accessioni | A6H7C9Primary (citable) accession number: A6H7C9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | July 24, 2007 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families