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Protein

Deoxynucleotidyltransferase terminal-interacting protein 1

Gene

DNTTIP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi159 – 173A.T hookCuratedAdd BLAST15
DNA bindingi216 – 237H-T-H motifCuratedAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxynucleotidyltransferase terminal-interacting protein 1
Alternative name(s):
Terminal deoxynucleotidyltransferase-interacting factor 1
Short name:
TdIF1
Short name:
TdT-interacting factor 1
Gene namesi
Name:DNTTIP1
Synonyms:TDIF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:28151 DNTTIP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261361 – 329Deoxynucleotidyltransferase terminal-interacting protein 1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA6H7A8
PRIDEiA6H7A8

Expressioni

Gene expression databases

BgeeiENSBTAG00000016743 Expressed in 10 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Monomer and homodimer. A minor proportion may form homotrimers. Interacts with ZNF541. Interacts with the terminal deoxynucleotidyltransferase DNTT. Interacts with TRERF1. Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain. Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022261

Structurei

3D structure databases

SMRiA6H7A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 147Important for dimerizationBy similarityAdd BLAST92
Regioni197 – 316Important for DNA and nucleosome bindingBy similarityAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi164 – 170Nuclear localization signalSequence analysis7

Domaini

The N-terminal domain mediates dimerization.By similarity
The C-terminal domain mediates interaction with DNA and nucleosomes. It contains a HTH motif that mediates recognition of the consensus sequence.By similarity

Phylogenomic databases

eggNOGiKOG4801 Eukaryota
ENOG410XPIX LUCA
GeneTreeiENSGT00510000047836
HOGENOMiHOG000059597
HOVERGENiHBG057022
InParanoidiA6H7A8
KOiK08707
OMAiWMVEKMR
OrthoDBiEOG091G0E9R
TreeFamiTF329275

Family and domain databases

InterProiView protein in InterPro
IPR026064 TdIF1
PANTHERiPTHR23399 PTHR23399, 1 hit

Sequencei

Sequence statusi: Complete.

A6H7A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGATGDVEQP RGPGGAERGG PELGDAGAAG QLVLTNPWNI MIKHRQVQRR
60 70 80 90 100
GRRSQMTTSF TDPAISMDLL RAVLQPSINE EIQTVFNKYM KFFQKAALNV
110 120 130 140 150
RDNVGEEVDA EQLIQEACRS CLEQAKLLFS DGEKVIPRLT HELPGIKRGR
160 170 180 190 200
QAEEECALRG SPIPKKRKGR PPGHILANDR AATGMVWKPK SCEPIRREGP
210 220 230 240 250
KWDPARLNES TTFVLGSRAN KALGMGGTRG RIYIKHPHLF KYAADPQDKH
260 270 280 290 300
WLAEQHHMRA TGGKMAYLLI EEDIRDLAAS DDYRGCLDLK LEELKSFVLP
310 320
SWMVEKMRKY METLRTENEH RAVEAPPQT
Length:329
Mass (Da):37,012
Last modified:July 24, 2007 - v1
Checksum:iF8217ACF753BFE41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146175 mRNA Translation: AAI46176.1
RefSeqiNP_001092346.1, NM_001098876.1
UniGeneiBt.8972

Genome annotation databases

EnsembliENSBTAT00000022261; ENSBTAP00000022261; ENSBTAG00000016743
GeneIDi505524
KEGGibta:505524

Similar proteinsi

Entry informationi

Entry nameiTDIF1_BOVIN
AccessioniPrimary (citable) accession number: A6H7A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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