UniProtKB - A6H784 (SCO2_BOVIN)
Protein SCO2 homolog, mitochondrial
SCO2
Functioni
Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 133 | CopperBy similarity | 1 | |
Metal bindingi | 137 | CopperBy similarity | 1 | |
Metal bindingi | 224 | CopperBy similarity | 1 |
GO - Molecular functioni
- copper chaperone activity Source: InterPro
- copper ion binding Source: InterPro
- protein-disulfide reductase activity Source: UniProtKB
GO - Biological processi
- cellular copper ion homeostasis Source: InterPro
- eye development Source: Ensembl
- in utero embryonic development Source: Ensembl
- mitochondrial cytochrome c oxidase assembly Source: UniProtKB
- muscle system process Source: Ensembl
- respiratory electron transport chain Source: Ensembl
- response to activity Source: Ensembl
Keywordsi
Molecular function | Chaperone |
Ligand | Copper, Metal-binding |
Enzyme and pathway databases
Reactomei | R-BTA-5628897, TP53 Regulates Metabolic Genes R-BTA-611105, Respiratory electron transport R-BTA-9707564, Cytoprotection by HMOX1 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein SCO2 homolog, mitochondrial |
Gene namesi | Name:SCO2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000012609 |
VGNCi | VGNC:106917, SCO2 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein Sequence analysis
Mitochondrion
- integral component of mitochondrial inner membrane Source: UniProtKB
Other locations
- myofibril Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 42 – 60 | Mitochondrial matrixBy similarityAdd BLAST | 19 | |
Transmembranei | 61 – 78 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 79 – 266 | Mitochondrial intermembraneBy similarityAdd BLAST | 188 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 41 | MitochondrionSequence analysisAdd BLAST | 41 | |
ChainiPRO_0000354067 | 42 – 266 | Protein SCO2 homolog, mitochondrialAdd BLAST | 225 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 133 ↔ 137 | Redox-activePROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | A6H784 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000012609, Expressed in olfactory segment of nasal mucosa and 96 other tissues |
Interactioni
Subunit structurei
Homodimer.
Interacts with COA6.
Found in a complex with TMEM177, COX20, COA6, MT-CO2/COX2, COX18 and SCO1.
Interacts with TMEM177 in a COX20-dependent manner.
Interacts with COX20 in a MT-CO2/COX2- and COX18-dependent manner.
Interacts with COX16.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016742 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 259 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 175 |
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2792, Eukaryota |
GeneTreei | ENSGT00390000004323 |
HOGENOMi | CLU_050131_0_3_1 |
InParanoidi | A6H784 |
OMAi | KHAGRDY |
OrthoDBi | 1462537at2759 |
TreeFami | TF313752 |
Family and domain databases
CDDi | cd02968, SCO, 1 hit |
InterProi | View protein in InterPro IPR003782, SCO1/SenC IPR017276, Synth_of_cyt-c-oxidase_Sco1/2 IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR12151, PTHR12151, 1 hit |
Pfami | View protein in Pfam PF02630, SCO1-SenC, 1 hit |
PIRSFi | PIRSF037736, SCO1, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLLLARPPKA WHRLFQLQPL ALLGTPGGKT QHVRYQLFST PGPADTGRQG
60 70 80 90 100
QPQGPGLRTR LLVTALVGAG LGGAWLALRA EKERGRQQQR TEALRQAAVG
110 120 130 140 150
QGDFSLLDHR GRVRCKADFR GQWVLLYFGF THCPDICPDE LEKLVQVVRQ
160 170 180 190 200
LEAEPGLPPV QPLFITVDPE RDTVAAMARY VQDFHPRLLG LTGSAEQIAQ
210 220 230 240 250
VSRSYRVYYS AGPKDEDQDY IVDHSIAIYL LSPDGLFTDY YSRARSAEQI
260
TDSVRRHMAA FRSVLR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC146150 mRNA Translation: AAI46151.1 |
RefSeqi | NP_001098963.1, NM_001105493.2 XP_010804121.1, XM_010805819.2 XP_010804122.1, XM_010805820.2 |
Genome annotation databases
Ensembli | ENSBTAT00000016742; ENSBTAP00000016742; ENSBTAG00000012609 |
GeneIDi | 100125923 |
KEGGi | bta:100125923 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC146150 mRNA Translation: AAI46151.1 |
RefSeqi | NP_001098963.1, NM_001105493.2 XP_010804121.1, XM_010805819.2 XP_010804122.1, XM_010805820.2 |
3D structure databases
SMRi | A6H784 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016742 |
Proteomic databases
PaxDbi | A6H784 |
Genome annotation databases
Ensembli | ENSBTAT00000016742; ENSBTAP00000016742; ENSBTAG00000012609 |
GeneIDi | 100125923 |
KEGGi | bta:100125923 |
Organism-specific databases
CTDi | 9997 |
VEuPathDBi | HostDB:ENSBTAG00000012609 |
VGNCi | VGNC:106917, SCO2 |
Phylogenomic databases
eggNOGi | KOG2792, Eukaryota |
GeneTreei | ENSGT00390000004323 |
HOGENOMi | CLU_050131_0_3_1 |
InParanoidi | A6H784 |
OMAi | KHAGRDY |
OrthoDBi | 1462537at2759 |
TreeFami | TF313752 |
Enzyme and pathway databases
Reactomei | R-BTA-5628897, TP53 Regulates Metabolic Genes R-BTA-611105, Respiratory electron transport R-BTA-9707564, Cytoprotection by HMOX1 |
Gene expression databases
Bgeei | ENSBTAG00000012609, Expressed in olfactory segment of nasal mucosa and 96 other tissues |
Family and domain databases
CDDi | cd02968, SCO, 1 hit |
InterProi | View protein in InterPro IPR003782, SCO1/SenC IPR017276, Synth_of_cyt-c-oxidase_Sco1/2 IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR12151, PTHR12151, 1 hit |
Pfami | View protein in Pfam PF02630, SCO1-SenC, 1 hit |
PIRSFi | PIRSF037736, SCO1, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCO2_BOVIN | |
Accessioni | A6H784Primary (citable) accession number: A6H784 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2008 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 23, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families