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Protein

Keratin, type I cytoskeletal 26

Gene

KRT26

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-BTA-6805567 Keratinization
R-BTA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 26
Alternative name(s):
Cytokeratin-26
Short name:
CK-26
Keratin-26
Short name:
K26
Type I inner root sheath-specific keratin-K25irs2
Gene namesi
Name:KRT26By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:30725 KRT26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126961 – 469Keratin, type I cytoskeletal 26Add BLAST469

Proteomic databases

PaxDbiA6H712
PeptideAtlasiA6H712
PRIDEiA6H712

Expressioni

Gene expression databases

BgeeiENSBTAG00000030546

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040717

Structurei

3D structure databases

ProteinModelPortaliA6H712
SMRiA6H712
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 398IF rodPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadSequence analysisAdd BLAST82
Regioni83 – 118Coil 1ASequence analysisAdd BLAST36
Regioni119 – 140Linker 1Sequence analysisAdd BLAST22
Regioni141 – 232Coil 1BSequence analysisAdd BLAST92
Regioni233 – 255Linker 12Sequence analysisAdd BLAST23
Regioni256 – 394Coil 2Sequence analysisAdd BLAST139
Regioni395 – 465TailSequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 81Gly-richSequence analysisAdd BLAST65

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JA2D Eukaryota
ENOG4111D4X LUCA
GeneTreeiENSGT00910000144130
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiA6H712
KOiK07604
OMAiRYFSVIE
OrthoDBiEOG091G087I
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6H712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRLSSGSR RLCSPAGSGQ LTGGRTGFRA GNACGGLGAG SSFSGPLGSV
60 70 80 90 100
SSRGSFSHGG GGLGSGVCTG FLENEHGLLP GNEKVTLQNL NDRLASYLDH
110 120 130 140 150
VCTLEEANAD LEQKIKGWYE KYGPGSGRQL AYDCSKYFSV TEDLKRQIIS
160 170 180 190 200
VTTCNASIAL QNENARLTAD DFRLKYENEL ALNQSVEADI NGLHRVMEEL
210 220 230 240 250
TLCTSDLEIQ CEALSEELTC LKKNHQEEMK VMQGAAGGNV NVEINAAPGV
260 270 280 290 300
DLTVLLNNMR AEYEDLAEQN REDAEAWFNE KSTSLHQQIS DDAGAATAAR
310 320 330 340 350
NELMELKRNL QTLEIELQSL MAMKHSYECS LAETESNYCH QLQQIQEQIG
360 370 380 390 400
ATEDQLQQIR METEGQKLEH ERLLDVKIFL EKEIEMYCKL IDGEGRKSKS
410 420 430 440 450
TYCKSEGRGP KNSENQVKDS KEEAVVKTVV GELDQLGSVL SLRVHSVEEK
460
SSKISNITME QRLPSKVPQ
Length:469
Mass (Da):51,578
Last modified:July 24, 2007 - v1
Checksum:i3C7F6D81765AFBA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146074 mRNA Translation: AAI46075.1
RefSeqiNP_001092566.1, NM_001099096.1
UniGeneiBt.88351

Genome annotation databases

EnsembliENSBTAT00000043126; ENSBTAP00000040717; ENSBTAG00000030546
GeneIDi539216
KEGGibta:539216

Similar proteinsi

Entry informationi

Entry nameiK1C26_BOVIN
AccessioniPrimary (citable) accession number: A6H712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: June 20, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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