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Entry version 88 (08 May 2019)
Sequence version 1 (24 Jul 2007)
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Protein

Leucine-rich repeat and IQ domain-containing protein 4

Gene

Lrriq4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat and IQ domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrriq4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915557 Lrriq4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003321391 – 596Leucine-rich repeat and IQ domain-containing protein 4Add BLAST596

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6H6A4

PRoteomics IDEntifications database

More...
PRIDEi
A6H6A4

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6H6A4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027703 Expressed in 10 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6H6A4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000103902

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati22 – 44LRR 1Add BLAST23
Repeati59 – 83LRR 2Add BLAST25
Repeati84 – 106LRR 3Add BLAST23
Repeati108 – 129LRR 4Add BLAST22
Repeati130 – 152LRR 5Add BLAST23
Repeati153 – 176LRR 6Add BLAST24
Repeati177 – 200LRR 7Add BLAST24
Repeati202 – 223LRR 8Add BLAST22
Repeati224 – 246LRR 9Add BLAST23
Repeati248 – 269LRR 10Add BLAST22
Repeati270 – 293LRR 11Add BLAST24
Repeati295 – 315LRR 12Add BLAST21
Repeati317 – 337LRR 13Add BLAST21
Repeati338 – 361LRR 14Add BLAST24
Repeati362 – 384LRR 15Add BLAST23
Repeati385 – 407LRR 16Add BLAST23
Repeati410 – 433LRR 17Add BLAST24
Repeati434 – 457LRR 18Add BLAST24
Repeati459 – 479LRR 19Add BLAST21
Repeati480 – 502LRR 20Add BLAST23
Repeati504 – 525LRR 21Add BLAST22
Repeati527 – 549LRR 22Add BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini540 – 569IQPROSITE-ProRule annotationAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113384

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6H6A4

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLMDNPM

Database of Orthologous Groups

More...
OrthoDBi
826997at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612 IQ, 1 hit
PF13855 LRR_8, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 13 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51450 LRR, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A6H6A4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHHSSSGSRC VLQNGLELTV ILPRLHRFDI IDTFKTLTKE LLRQEHLPKV
60 70 80 90 100
LQKKEPHQLT DRTFFIDGSN QGLKTIPSEI LALKELEEVH LENNQIAEIP
110 120 130 140 150
QGIQQLQNTK VLYLHNNSLQ DLCPELGALS SLESLDLSGN PLVISSLHVV
160 170 180 190 200
SRLRTLRELR LYRTGLTEIP TGICKSLHHL ELFGLSENFL ESLPEEIVNQ
210 220 230 240 250
TKLREIYLKQ NHFEVFPCDL CVLYNLEVID LDENKLKSIP GDIGHLVRLQ
260 270 280 290 300
KFYVASNHLM SLPESLSQCS KLSVLDLTHN SIHSLPSSLE LLTELTEVGL
310 320 330 340 350
SGNRLEKVPR LLCSWVSLHL LYLRNTSLHG LRDSFKRLIN LRFLDLSQNH
360 370 380 390 400
IEHFPVQICA LKNLEILALD DNKVRQLPPS ISLLSNLKIL GLTGNDLLSF
410 420 430 440 450
PEEIFSLISL EKLYIGQDQG SKLSSLPENI KRLMNLKELY IENNRLEQLP
460 470 480 490 500
ASLGLMPNLE VLDCRHNLLK QLPDAICRTR NLRELLLEDN LLCCLPENLD
510 520 530 540 550
HLVNLKVLTL MNNPMVDPPI YVCNQGNEAI WKHLKENRIR KMMATTIQAW
560 570 580 590
WRGIMVRKGY GSYEELLKAR KKGKSPPKDK KGKKAAKGKP EKGNKK
Length:596
Mass (Da):68,010
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i040BCA23D412537E
GO
Isoform 2 (identifier: A6H6A4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MHHSSSGSRCVLQNGLELTVILPRL → MAYPSAKLQM

Show »
Length:581
Mass (Da):66,401
Checksum:i97AD444E49C0E1F0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0333391 – 25MHHSS…ILPRL → MAYPSAKLQM in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK015024 mRNA Translation: BAB29680.1
BC145806 mRNA Translation: AAI45807.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38406.1 [A6H6A4-1]
CCDS71229.1 [A6H6A4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001277439.1, NM_001290510.1 [A6H6A4-2]
NP_080944.2, NM_026668.2 [A6H6A4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000108265; ENSMUSP00000103900; ENSMUSG00000027703 [A6H6A4-2]
ENSMUST00000108267; ENSMUSP00000103902; ENSMUSG00000027703 [A6H6A4-1]
ENSMUST00000172350; ENSMUSP00000127052; ENSMUSG00000027703 [A6H6A4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
68307

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68307

UCSC genome browser

More...
UCSCi
uc008ovc.1 mouse [A6H6A4-1]
uc008ovd.2 mouse [A6H6A4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015024 mRNA Translation: BAB29680.1
BC145806 mRNA Translation: AAI45807.1
CCDSiCCDS38406.1 [A6H6A4-1]
CCDS71229.1 [A6H6A4-2]
RefSeqiNP_001277439.1, NM_001290510.1 [A6H6A4-2]
NP_080944.2, NM_026668.2 [A6H6A4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103902

PTM databases

PhosphoSitePlusiA6H6A4

Proteomic databases

PaxDbiA6H6A4
PRIDEiA6H6A4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108265; ENSMUSP00000103900; ENSMUSG00000027703 [A6H6A4-2]
ENSMUST00000108267; ENSMUSP00000103902; ENSMUSG00000027703 [A6H6A4-1]
ENSMUST00000172350; ENSMUSP00000127052; ENSMUSG00000027703 [A6H6A4-1]
GeneIDi68307
KEGGimmu:68307
UCSCiuc008ovc.1 mouse [A6H6A4-1]
uc008ovd.2 mouse [A6H6A4-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
344657
MGIiMGI:1915557 Lrriq4

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000161601
HOGENOMiHOG000113384
InParanoidiA6H6A4
OMAiTLMDNPM
OrthoDBi826997at2759
TreeFamiTF351429

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A6H6A4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027703 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiA6H6A4 MM

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 13 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51450 LRR, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRIQ4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6H6A4
Secondary accession number(s): Q9D5Q5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: May 8, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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