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Protein

SAC3 domain-containing protein 1

Gene

Sac3d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in centrosome duplication and mitotic progression.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome duplication Source: MGI
  • negative regulation of JAK-STAT cascade Source: MGI
  • regulation of immune response Source: MGI
  • spindle assembly Source: MGI

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
SAC3 domain-containing protein 1
Alternative name(s):
SAC3 homology domain-containing protein 1
Gene namesi
Name:Sac3d1
Synonyms:Shd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913656 Sac3d1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003082051 – 427SAC3 domain-containing protein 1Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei425PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6H687
MaxQBiA6H687
PaxDbiA6H687
PeptideAtlasiA6H687
PRIDEiA6H687

PTM databases

iPTMnetiA6H687
PhosphoSitePlusiA6H687

Expressioni

Tissue specificityi

Present in spleen cells (at protein level).1 Publication

Gene expression databases

CleanExiMM_SAC3D1

Interactioni

Subunit structurei

May be part of a SEM1-containing complex.By similarity

Protein-protein interaction databases

BioGridi211450, 1 interactor
CORUMiA6H687
STRINGi10090.ENSMUSP00000109161

Structurei

3D structure databases

ProteinModelPortaliA6H687
SMRiA6H687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 397PCIPROSITE-ProRule annotationAdd BLAST169

Sequence similaritiesi

Belongs to the SAC3 family.Curated

Phylogenomic databases

eggNOGiKOG1860 Eukaryota
COG5079 LUCA
HOGENOMiHOG000168632
HOVERGENiHBG108455
InParanoidiA6H687
KOiK16734
PhylomeDBiA6H687

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF03399 SAC3_GANP, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6H687-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRFKGENRS QARWIMGGVS KGRGSGKSRK PRQAAFGQTG ARVCPSSPQQ
60 70 80 90 100
DAVPRFRWPG DAECASSTHT PTMSGCKLPM GLCPDMCPAA ERARRERERR
110 120 130 140 150
LHRLEVEPGG RGNAPRADPK RTVKEYSRPA AGKPRPPPSL LRPPPVLLAT
160 170 180 190 200
VRYLAGEVAG RGDVSCAEVA SFVADRLRAV RLDLSLQGVD DADAATVLEA
210 220 230 240 250
ALATLLAVVA RVRPEETRGA ADPVLLQTQV QEGFGSLRRC YARGKGPYPR
260 270 280 290 300
QAAFQGLFLL YNLGSVEALQ EVLQLPAALR ACPPLQAALA VDAAFREDNH
310 320 330 340 350
ARLFRLLRTL PYLQSCAVQE HIGYARRKAL ARLSRALSTP KGQTLPLDFI
360 370 380 390 400
EHFLALDGLQ EARDLCQAHG LTLDKDRVVF LRGQYSEEGL PPPGAYHILV
410 420
GNKLQGHTLE DVVMAEEGDI HRPGSAA
Length:427
Mass (Da):46,384
Last modified:July 24, 2007 - v1
Checksum:i99C5F943CCD935AE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8Q7G5E8Q7_MOUSE
SAC3 domain containing 1, isoform C...
Sac3d1 mCG_11785
427Annotation score:

Sequence cautioni

The sequence BAC36061 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49Q → R in CAB65242 (PubMed:15322101).Curated1
Sequence conflicti266 – 276VEALQEVLQLP → LEAPAGGST in CAB65242 (PubMed:15322101).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131957 mRNA Translation: CAB65242.2
BC144812 mRNA Translation: AAI44813.1
BC145789 mRNA Translation: AAI45790.1
AK075930 mRNA Translation: BAC36061.1 Different initiation.
CCDSiCCDS37896.1
RefSeqiNP_598439.3, NM_133678.3
UniGeneiMm.303924

Genome annotation databases

GeneIDi66406
KEGGimmu:66406

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131957 mRNA Translation: CAB65242.2
BC144812 mRNA Translation: AAI44813.1
BC145789 mRNA Translation: AAI45790.1
AK075930 mRNA Translation: BAC36061.1 Different initiation.
CCDSiCCDS37896.1
RefSeqiNP_598439.3, NM_133678.3
UniGeneiMm.303924

3D structure databases

ProteinModelPortaliA6H687
SMRiA6H687
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211450, 1 interactor
CORUMiA6H687
STRINGi10090.ENSMUSP00000109161

PTM databases

iPTMnetiA6H687
PhosphoSitePlusiA6H687

Proteomic databases

EPDiA6H687
MaxQBiA6H687
PaxDbiA6H687
PeptideAtlasiA6H687
PRIDEiA6H687

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi66406
KEGGimmu:66406

Organism-specific databases

CTDi29901
MGIiMGI:1913656 Sac3d1

Phylogenomic databases

eggNOGiKOG1860 Eukaryota
COG5079 LUCA
HOGENOMiHOG000168632
HOVERGENiHBG108455
InParanoidiA6H687
KOiK16734
PhylomeDBiA6H687

Miscellaneous databases

PROiPR:A6H687
SOURCEiSearch...

Gene expression databases

CleanExiMM_SAC3D1

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF03399 SAC3_GANP, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAC31_MOUSE
AccessioniPrimary (citable) accession number: A6H687
Secondary accession number(s): B7ZMU9, Q8BVY1, Q9QXE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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