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Protein

NACHT domain- and WD repeat-containing protein 1

Gene

Nwd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the control of androgen receptor (AR) protein steady-state levels.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi342 – 349ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT domain- and WD repeat-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nwd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442268 Nwd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003082551 – 1563NACHT domain- and WD repeat-containing protein 1Add BLAST1563

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6H603

PeptideAtlas

More...
PeptideAtlasi
A6H603

PRoteomics IDEntifications database

More...
PRIDEi
A6H603

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6H603

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6H603

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048148 Expressed in 87 organ(s), highest expression level in olfactory epithelium

CleanEx database of gene expression profiles

More...
CleanExi
MM_NWD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6H603 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6H603 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with HSP90AA1, HSP90AB1 and BAG2.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000124804

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6H603

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati274 – 314WD 1Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini336 – 666NACHTAdd BLAST331
Repeati866 – 905WD 2Add BLAST40
Repeati908 – 947WD 3Add BLAST40
Repeati954 – 994WD 4Add BLAST41
Repeati998 – 1037WD 5Add BLAST40
Repeati1044 – 1082WD 6Add BLAST39
Repeati1126 – 1165WD 7Add BLAST40
Repeati1168 – 1207WD 8Add BLAST40
Repeati1212 – 1251WD 9Add BLAST40
Repeati1253 – 1292WD 10Add BLAST40
Repeati1346 – 1385WD 11Add BLAST40
Repeati1386 – 1425WD 12Add BLAST40
Repeati1431 – 1470WD 13Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0266 Eukaryota
KOG3602 Eukaryota
COG2319 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161635

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168522

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108205

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6H603

Database of Orthologous Groups

More...
OrthoDBi
20367at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6H603

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977 Apc4_WD40_dom
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF05729 NACHT, 1 hit
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6H603-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTEREALQC TAYPEVQSFC QRHGLAFEVV DLRWGIPNTQ ATDYLTTELC
60 70 80 90 100
LEELERCQKT SIGPAFVALL GDQYGPCPVP RRIEEKEWEA LRAQLTSRPR
110 120 130 140 150
DLELVTRHFQ RDDNTIPPTY VLQPSGSLVV PGPEEATLTS VLRGGAQEAW
160 170 180 190 200
RLGLISQEQW MCYHRSVIEW EIELGLLSSA RGDQGATVFL RDVQDLNKHI
210 220 230 240 250
LDDCSLKMVD RLVDGCLDTN AQSLLSGLKG RILDAQPGAL KSHHLSWSRD
260 270 280 290 300
LVNPKNKAHA RYLKQLSEQF VARTNHQVLE QLRELELARQ ELGWLYQEIR
310 320 330 340 350
HHLWQSTEST KVFCGHQELL AQLRQQLRQD ESRTHTPLVL FGPPGIGKTS
360 370 380 390 400
LMCKLAQQVP ELLGHKTVVV LRLLGTSKLS LDARSLLRSL SFQVCLAYGL
410 420 430 440 450
PLPPAQVLEA HSRVGHFFHT LLHTVSQRNF ESLVLLLDSV DDLDSICHSP
460 470 480 490 500
RVSWLPLKCP PRVHLILSTC SGQQVLHNLQ QTLKDPSTYW EVKALSGSQG
510 520 530 540 550
QEFIQLLLAA EKRMLSPGQR DVLWASLPEC GHPGRLRLAF EEARKWASFT
560 570 580 590 600
VPVPLATTAE EATHQLCIRL EETHGALLVA HVLGYIVSSR YGLSEAELKD
610 620 630 640 650
VLSLDDEVLQ AVYRDWTPPS KELLRFPPLL WVRLRRDLGH CLVRRPVDGC
660 670 680 690 700
MLLAIAHRQL SQVIQVRYLS GPERAKRHGV LAEFFSGAWS QGIKKLITLP
710 720 730 740 750
LVGKPLNLDR KVAPQPLWFS STVANLRKLT ELPFHLLHAG RLEELKQEVL
760 770 780 790 800
GNMSWISCRG ISGGIEVLLD DFDMCAPHMN SPEVDLVREA IQLCGPAVEL
810 820 830 840 850
RGLEKSVLYT ELLARLLFFA ASHPAMIGQL CQQAQSWFRA CPYPMLVPLA
860 870 880 890 900
GFLQPPGGPL RATLTGCHKG ITAIAWSLEE KLLVVGTQDG AMVVWDVEEQ
910 920 930 940 950
QVVHVLMGHT AEVKCVRVFA QGTLAISASK DHTLRLWSLL SGQEKVTILD
960 970 980 990 1000
GGSQNPTEPQ SWDLHVDERN NVVYSTSGAR INMWNLETSK LVFCITGDVS
1010 1020 1030 1040 1050
DPWVCVALLA AQGLLLALSK GGQVSLWSSA MGKLQEKHQL SSIKEETPTC
1060 1070 1080 1090 1100
AVSIQSRARL VAGFSSGSIA LVSAGEDRLL EKLPEAVGFL VVSEDDSLLV
1110 1120 1130 1140 1150
AGFGRFVRIF LADSQGFHRF MASDLEHEDM VETAVLGPEN NLIITGSRDA
1160 1170 1180 1190 1200
LIQVWSLSEQ GTLLNVLEGV GAPVSLLVRG GTLVVSASRK SSSFKVWDLK
1210 1220 1230 1240 1250
STKKLQSPTP FLDRTGLAAV SHHGSFVYFP KVGDKNKVTI WDLAEGEEQD
1260 1270 1280 1290 1300
CLDTSNEVRC LEVAEQAKLL FTGLVSGIVL VFPLNSRQDV LCIPPPEARK
1310 1320 1330 1340 1350
AVNCMSLSKS ENRLAIAYDN IVLVLDISPG DPCPAIEGPT YTFYTQLPET
1360 1370 1380 1390 1400
IVSVAVLADY RVVYGMSDGS LFLYDCACSK VFPLEAHGSR VSCVEVSHSE
1410 1420 1430 1440 1450
QLAVSGAEDA LLCLWDLQAC RGMFEMSYEN SCCRGVRCAC FSRDDKHVFA
1460 1470 1480 1490 1500
GMEDRSVTAW STVDGTLLAV QFVHAVINRI IPTSNGFMAP TSHGYLIRER
1510 1520 1530 1540 1550
FQCPSVRASQ QDPLKNFKKA VWLVKTRQRE ELAAAEASQD AEPVAVEGKE
1560
SKSNKRSQVC LIL
Note: No experimental confirmation available.
Length:1,563
Mass (Da):173,270
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FF4DA161866F3E4
GO
Isoform 2 (identifier: A6H603-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1435: NSCCRG → VGGLDN
     1436-1563: Missing.

Note: No experimental confirmation available.
Show »
Length:1,435
Mass (Da):158,946
Checksum:i4D31A16CB1D5550F
GO
Isoform 3 (identifier: A6H603-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.
     1430-1435: NSCCRG → VGGLDN
     1436-1563: Missing.

Note: No experimental confirmation available.
Show »
Length:1,228
Mass (Da):135,478
Checksum:i0EE1F863C6CFD1C4
GO
Isoform 4 (identifier: A6H603-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     911-911: A → V
     912-1563: Missing.

Note: No experimental confirmation available.
Show »
Length:911
Mass (Da):102,276
Checksum:iEDAFD1B914A40C6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CX99E0CX99_MOUSE
NACHT domain- and WD repeat-contain...
Nwd1
1,521Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BR96A0A2I3BR96_MOUSE
NACHT domain- and WD repeat-contain...
Nwd1
1,562Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CY71E0CY71_MOUSE
NACHT domain- and WD repeat-contain...
Nwd1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI45704 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE37101 differs from that shown. Reason: Frameshift at positions 183, 1050 and 1175.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213V → A in AAI45704 (PubMed:15489334).Curated1
Sequence conflicti218D → G in BAC28860 (PubMed:16141072).Curated1
Sequence conflicti326Q → R in AAI45704 (PubMed:15489334).Curated1
Sequence conflicti356A → T in BAE37101 (PubMed:16141072).Curated1
Sequence conflicti410A → V in AAI45704 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0289421 – 207Missing in isoform 3. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_028943911A → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_028944912 – 1563Missing in isoform 4. 1 PublicationAdd BLAST652
Alternative sequenceiVSP_0289451430 – 1435NSCCRG → VGGLDN in isoform 2 and isoform 3. 2 Publications6
Alternative sequenceiVSP_0289461436 – 1563Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK034868 mRNA Translation: BAC28860.1
AK162888 mRNA Translation: BAE37101.1 Frameshift.
AC171917 Genomic DNA No translation available.
BC145703 mRNA Translation: AAI45704.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
XP_006531150.1, XM_006531087.3 [A6H603-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.390076

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093427; ENSMUSP00000091135; ENSMUSG00000048148 [A6H603-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
319555

UCSC genome browser

More...
UCSCi
uc012gfx.1 mouse [A6H603-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034868 mRNA Translation: BAC28860.1
AK162888 mRNA Translation: BAE37101.1 Frameshift.
AC171917 Genomic DNA No translation available.
BC145703 mRNA Translation: AAI45704.1 Different initiation.
RefSeqiXP_006531150.1, XM_006531087.3 [A6H603-1]
UniGeneiMm.390076

3D structure databases

ProteinModelPortaliA6H603
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124804

PTM databases

iPTMnetiA6H603
PhosphoSitePlusiA6H603

Proteomic databases

PaxDbiA6H603
PeptideAtlasiA6H603
PRIDEiA6H603

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093427; ENSMUSP00000091135; ENSMUSG00000048148 [A6H603-1]
GeneIDi319555
UCSCiuc012gfx.1 mouse [A6H603-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284434
MGIiMGI:2442268 Nwd1

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
KOG3602 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00940000161635
HOGENOMiHOG000168522
HOVERGENiHBG108205
InParanoidiA6H603
OrthoDBi20367at2759
PhylomeDBiA6H603

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A6H603

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000048148 Expressed in 87 organ(s), highest expression level in olfactory epithelium
CleanExiMM_NWD1
ExpressionAtlasiA6H603 baseline and differential
GenevisibleiA6H603 MM

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF05729 NACHT, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 10 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNWD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6H603
Secondary accession number(s): Q3TRC9, Q8BS99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: January 16, 2019
This is version 95 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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