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Protein

NACHT domain- and WD repeat-containing protein 1

Gene

Nwd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the control of androgen receptor (AR) protein steady-state levels.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi342 – 349ATPSequence analysis8

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT domain- and WD repeat-containing protein 1
Gene namesi
Name:Nwd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2442268 Nwd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003082551 – 1563NACHT domain- and WD repeat-containing protein 1Add BLAST1563

Proteomic databases

PaxDbiA6H603
PeptideAtlasiA6H603
PRIDEiA6H603

PTM databases

iPTMnetiA6H603
PhosphoSitePlusiA6H603

Expressioni

Gene expression databases

BgeeiENSMUSG00000048148 Expressed in 87 organ(s), highest expression level in olfactory epithelium
CleanExiMM_NWD1
ExpressionAtlasiA6H603 baseline and differential
GenevisibleiA6H603 MM

Interactioni

Subunit structurei

May interact with HSP90AA1, HSP90AB1 and BAG2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124804

Structurei

3D structure databases

ProteinModelPortaliA6H603
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati274 – 314WD 1Add BLAST41
Domaini336 – 666NACHTAdd BLAST331
Repeati866 – 905WD 2Add BLAST40
Repeati908 – 947WD 3Add BLAST40
Repeati954 – 994WD 4Add BLAST41
Repeati998 – 1037WD 5Add BLAST40
Repeati1044 – 1082WD 6Add BLAST39
Repeati1126 – 1165WD 7Add BLAST40
Repeati1168 – 1207WD 8Add BLAST40
Repeati1212 – 1251WD 9Add BLAST40
Repeati1253 – 1292WD 10Add BLAST40
Repeati1346 – 1385WD 11Add BLAST40
Repeati1386 – 1425WD 12Add BLAST40
Repeati1431 – 1470WD 13Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
KOG3602 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00530000063450
HOGENOMiHOG000168522
HOVERGENiHBG108205
InParanoidiA6H603
OrthoDBiEOG091G05F0
PhylomeDBiA6H603

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF05729 NACHT, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 10 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6H603-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTEREALQC TAYPEVQSFC QRHGLAFEVV DLRWGIPNTQ ATDYLTTELC
60 70 80 90 100
LEELERCQKT SIGPAFVALL GDQYGPCPVP RRIEEKEWEA LRAQLTSRPR
110 120 130 140 150
DLELVTRHFQ RDDNTIPPTY VLQPSGSLVV PGPEEATLTS VLRGGAQEAW
160 170 180 190 200
RLGLISQEQW MCYHRSVIEW EIELGLLSSA RGDQGATVFL RDVQDLNKHI
210 220 230 240 250
LDDCSLKMVD RLVDGCLDTN AQSLLSGLKG RILDAQPGAL KSHHLSWSRD
260 270 280 290 300
LVNPKNKAHA RYLKQLSEQF VARTNHQVLE QLRELELARQ ELGWLYQEIR
310 320 330 340 350
HHLWQSTEST KVFCGHQELL AQLRQQLRQD ESRTHTPLVL FGPPGIGKTS
360 370 380 390 400
LMCKLAQQVP ELLGHKTVVV LRLLGTSKLS LDARSLLRSL SFQVCLAYGL
410 420 430 440 450
PLPPAQVLEA HSRVGHFFHT LLHTVSQRNF ESLVLLLDSV DDLDSICHSP
460 470 480 490 500
RVSWLPLKCP PRVHLILSTC SGQQVLHNLQ QTLKDPSTYW EVKALSGSQG
510 520 530 540 550
QEFIQLLLAA EKRMLSPGQR DVLWASLPEC GHPGRLRLAF EEARKWASFT
560 570 580 590 600
VPVPLATTAE EATHQLCIRL EETHGALLVA HVLGYIVSSR YGLSEAELKD
610 620 630 640 650
VLSLDDEVLQ AVYRDWTPPS KELLRFPPLL WVRLRRDLGH CLVRRPVDGC
660 670 680 690 700
MLLAIAHRQL SQVIQVRYLS GPERAKRHGV LAEFFSGAWS QGIKKLITLP
710 720 730 740 750
LVGKPLNLDR KVAPQPLWFS STVANLRKLT ELPFHLLHAG RLEELKQEVL
760 770 780 790 800
GNMSWISCRG ISGGIEVLLD DFDMCAPHMN SPEVDLVREA IQLCGPAVEL
810 820 830 840 850
RGLEKSVLYT ELLARLLFFA ASHPAMIGQL CQQAQSWFRA CPYPMLVPLA
860 870 880 890 900
GFLQPPGGPL RATLTGCHKG ITAIAWSLEE KLLVVGTQDG AMVVWDVEEQ
910 920 930 940 950
QVVHVLMGHT AEVKCVRVFA QGTLAISASK DHTLRLWSLL SGQEKVTILD
960 970 980 990 1000
GGSQNPTEPQ SWDLHVDERN NVVYSTSGAR INMWNLETSK LVFCITGDVS
1010 1020 1030 1040 1050
DPWVCVALLA AQGLLLALSK GGQVSLWSSA MGKLQEKHQL SSIKEETPTC
1060 1070 1080 1090 1100
AVSIQSRARL VAGFSSGSIA LVSAGEDRLL EKLPEAVGFL VVSEDDSLLV
1110 1120 1130 1140 1150
AGFGRFVRIF LADSQGFHRF MASDLEHEDM VETAVLGPEN NLIITGSRDA
1160 1170 1180 1190 1200
LIQVWSLSEQ GTLLNVLEGV GAPVSLLVRG GTLVVSASRK SSSFKVWDLK
1210 1220 1230 1240 1250
STKKLQSPTP FLDRTGLAAV SHHGSFVYFP KVGDKNKVTI WDLAEGEEQD
1260 1270 1280 1290 1300
CLDTSNEVRC LEVAEQAKLL FTGLVSGIVL VFPLNSRQDV LCIPPPEARK
1310 1320 1330 1340 1350
AVNCMSLSKS ENRLAIAYDN IVLVLDISPG DPCPAIEGPT YTFYTQLPET
1360 1370 1380 1390 1400
IVSVAVLADY RVVYGMSDGS LFLYDCACSK VFPLEAHGSR VSCVEVSHSE
1410 1420 1430 1440 1450
QLAVSGAEDA LLCLWDLQAC RGMFEMSYEN SCCRGVRCAC FSRDDKHVFA
1460 1470 1480 1490 1500
GMEDRSVTAW STVDGTLLAV QFVHAVINRI IPTSNGFMAP TSHGYLIRER
1510 1520 1530 1540 1550
FQCPSVRASQ QDPLKNFKKA VWLVKTRQRE ELAAAEASQD AEPVAVEGKE
1560
SKSNKRSQVC LIL
Note: No experimental confirmation available.
Length:1,563
Mass (Da):173,270
Last modified:October 23, 2007 - v2
Checksum:i5FF4DA161866F3E4
GO
Isoform 2 (identifier: A6H603-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1435: NSCCRG → VGGLDN
     1436-1563: Missing.

Note: No experimental confirmation available.
Show »
Length:1,435
Mass (Da):158,946
Checksum:i4D31A16CB1D5550F
GO
Isoform 3 (identifier: A6H603-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.
     1430-1435: NSCCRG → VGGLDN
     1436-1563: Missing.

Note: No experimental confirmation available.
Show »
Length:1,228
Mass (Da):135,478
Checksum:i0EE1F863C6CFD1C4
GO
Isoform 4 (identifier: A6H603-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     911-911: A → V
     912-1563: Missing.

Note: No experimental confirmation available.
Show »
Length:911
Mass (Da):102,276
Checksum:iEDAFD1B914A40C6D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CX99E0CX99_MOUSE
NACHT domain- and WD repeat-contain...
Nwd1
1,521Annotation score:
A0A2I3BR96A0A2I3BR96_MOUSE
NACHT domain- and WD repeat-contain...
Nwd1
1,562Annotation score:
E0CY71E0CY71_MOUSE
NACHT domain- and WD repeat-contain...
Nwd1
77Annotation score:

Sequence cautioni

The sequence AAI45704 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE37101 differs from that shown. Reason: Frameshift at positions 183, 1050 and 1175.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213V → A in AAI45704 (PubMed:15489334).Curated1
Sequence conflicti218D → G in BAC28860 (PubMed:16141072).Curated1
Sequence conflicti326Q → R in AAI45704 (PubMed:15489334).Curated1
Sequence conflicti356A → T in BAE37101 (PubMed:16141072).Curated1
Sequence conflicti410A → V in AAI45704 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0289421 – 207Missing in isoform 3. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_028943911A → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_028944912 – 1563Missing in isoform 4. 1 PublicationAdd BLAST652
Alternative sequenceiVSP_0289451430 – 1435NSCCRG → VGGLDN in isoform 2 and isoform 3. 2 Publications6
Alternative sequenceiVSP_0289461436 – 1563Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034868 mRNA Translation: BAC28860.1
AK162888 mRNA Translation: BAE37101.1 Frameshift.
AC171917 Genomic DNA No translation available.
BC145703 mRNA Translation: AAI45704.1 Different initiation.
RefSeqiXP_006531150.1, XM_006531087.3 [A6H603-1]
UniGeneiMm.390076

Genome annotation databases

EnsembliENSMUST00000093427; ENSMUSP00000091135; ENSMUSG00000048148 [A6H603-1]
GeneIDi319555
UCSCiuc012gfx.1 mouse [A6H603-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034868 mRNA Translation: BAC28860.1
AK162888 mRNA Translation: BAE37101.1 Frameshift.
AC171917 Genomic DNA No translation available.
BC145703 mRNA Translation: AAI45704.1 Different initiation.
RefSeqiXP_006531150.1, XM_006531087.3 [A6H603-1]
UniGeneiMm.390076

3D structure databases

ProteinModelPortaliA6H603
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124804

PTM databases

iPTMnetiA6H603
PhosphoSitePlusiA6H603

Proteomic databases

PaxDbiA6H603
PeptideAtlasiA6H603
PRIDEiA6H603

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093427; ENSMUSP00000091135; ENSMUSG00000048148 [A6H603-1]
GeneIDi319555
UCSCiuc012gfx.1 mouse [A6H603-3]

Organism-specific databases

CTDi284434
MGIiMGI:2442268 Nwd1

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
KOG3602 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00530000063450
HOGENOMiHOG000168522
HOVERGENiHBG108205
InParanoidiA6H603
OrthoDBiEOG091G05F0
PhylomeDBiA6H603

Miscellaneous databases

PROiPR:A6H603
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048148 Expressed in 87 organ(s), highest expression level in olfactory epithelium
CleanExiMM_NWD1
ExpressionAtlasiA6H603 baseline and differential
GenevisibleiA6H603 MM

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF05729 NACHT, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 10 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNWD1_MOUSE
AccessioniPrimary (citable) accession number: A6H603
Secondary accession number(s): Q3TRC9, Q8BS99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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