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Protein

Exocyst complex component 6B

Gene

Exoc6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Biological processi

  • exocytosis Source: GO_Central
  • Golgi to plasma membrane transport Source: GO_Central
  • vesicle docking involved in exocytosis Source: InterPro

Keywordsi

Biological processExocytosis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 6B
Alternative name(s):
Exocyst complex component Sec15B
SEC15-like protein 2
Gene namesi
Name:Exoc6b
Synonyms:Sec15b, Sec15l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1923164 Exoc6b

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004067781 – 810Exocyst complex component 6BAdd BLAST810

Proteomic databases

EPDiA6H5Z3
MaxQBiA6H5Z3
PaxDbiA6H5Z3
PeptideAtlasiA6H5Z3
PRIDEiA6H5Z3

PTM databases

iPTMnetiA6H5Z3
PhosphoSitePlusiA6H5Z3

Expressioni

Gene expression databases

BgeeiENSMUSG00000033769 Expressed in 201 organ(s), highest expression level in ear vesicle
ExpressionAtlasiA6H5Z3 baseline and differential
GenevisibleiA6H5Z3 MM

Interactioni

Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.By similarity

Protein-protein interaction databases

BioGridi217843, 1 interactor
STRINGi10090.ENSMUSP00000125312

Structurei

3D structure databases

ProteinModelPortaliA6H5Z3
SMRiA6H5Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili79 – 118Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the SEC15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2176 Eukaryota
ENOG410XQAE LUCA
GeneTreeiENSGT00390000005739
HOGENOMiHOG000290640
HOVERGENiHBG057543
InParanoidiA6H5Z3
KOiK19985
OMAiRDHYNEV
OrthoDBiEOG091G04HR
TreeFamiTF315199

Family and domain databases

InterProiView protein in InterPro
IPR007225 EXOC6/Sec15
PANTHERiPTHR12702 PTHR12702, 1 hit
PfamiView protein in Pfam
PF04091 Sec15, 1 hit
PIRSFiPIRSF025007 Sec15, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A6H5Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERAKMAEES LETAAEHERI LREIESTDTA CIGPTLRSVY DGEEHGRFME
60 70 80 90 100
KLETRIRNHD REIEKMCNFH YQGFVDSITE LLKVRGEAQK LKNQVTDTNR
110 120 130 140 150
KLQHEGKELV IAMEELKQCR LQQRNISATV DKLMLCLPVL EMYSKLRDQM
160 170 180 190 200
KTKRHYPALK TLEHLEHTYL PQVSHYRFCK VMVDNIPKLR EEIKDVSMSD
210 220 230 240 250
LKDFLESIRK HSDKIGETAM KQAQQQRNLD NIVLQQPRIG SKRKSKKDVY
260 270 280 290 300
TIFDAEVEST SPKSEQDSGI LDVEDEEDDE EVPGAQDLVD FSPVYRCLHI
310 320 330 340 350
YSVLGARETF ENYYRKQRRK QARLVLQPPS NMHETLDGYR KYFNQIVGFF
360 370 380 390 400
VVEDHILHTT QGLVNRAYID ELWEMALSKT IAALRTHSSY CSDPNLVLDL
410 420 430 440 450
KNLIVLFADT LQVYGFPVNQ LFDMLLEIRD QYSETLLKKW AGVFRNILDS
460 470 480 490 500
DNYSPIPVTS EETYKKVVGQ FPFQDIELEK QPFPKKFPFS EFVPKVYNQI
510 520 530 540 550
KEFIYACLKF SEDLHLSSTE VDDMIRKSTN LLLTRTLSNS LQNVIKRKNI
560 570 580 590 600
GLTELVQIII NTTHLEKSCK YLEEFITNIT NVLPETVHTT KLYGTTTFKD
610 620 630 640 650
ARHAAEEEIY TNLNQKIDQF LQLADYDWMT GDLDNKASDY LVDLIAFLRS
660 670 680 690 700
TFAVFTHLPG KVAQTACMSA CKHLATSLMQ LLLEAEVRQL TLGALQQFNL
710 720 730 740 750
DVRECEQFAR SGPVPGFQED TLQLAFIDLR QLLDLFIQWD WSTYLADYGQ
760 770 780 790 800
PNCKYLRVNP VTALTLLEKM KDTSRKNNMF AQFRKNERDK QKLIDTVAKQ
810
LRGLISSHHS
Length:810
Mass (Da):94,130
Last modified:July 24, 2007 - v1
Checksum:i9DC3AA54A4B36084
GO
Isoform 2 (identifier: A6H5Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-678: GKVAQTACMSACKHLATSL → VSDSSSILPFKVGNPCLTL
     679-810: Missing.

Show »
Length:678
Mass (Da):78,803
Checksum:i612A4740C4C82D12
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CY34E0CY34_MOUSE
Exocyst complex component 6B
Exoc6b
39Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040840660 – 678GKVAQ…LATSL → VSDSSSILPFKVGNPCLTL in isoform 2. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_040841679 – 810Missing in isoform 2. 2 PublicationsAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144547 mRNA Translation: BAE25933.1
CH466523 Genomic DNA Translation: EDK99119.1
BC144781 mRNA Translation: AAI44782.1
BC145693 mRNA Translation: AAI45694.1
CCDSiCCDS51824.1 [A6H5Z3-1]
RefSeqiNP_796051.2, NM_177077.2 [A6H5Z3-1]
UniGeneiMm.159621

Genome annotation databases

EnsembliENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769 [A6H5Z3-1]
GeneIDi75914
KEGGimmu:75914
UCSCiuc009cpa.2 mouse [A6H5Z3-1]
uc009cpb.2 mouse [A6H5Z3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144547 mRNA Translation: BAE25933.1
CH466523 Genomic DNA Translation: EDK99119.1
BC144781 mRNA Translation: AAI44782.1
BC145693 mRNA Translation: AAI45694.1
CCDSiCCDS51824.1 [A6H5Z3-1]
RefSeqiNP_796051.2, NM_177077.2 [A6H5Z3-1]
UniGeneiMm.159621

3D structure databases

ProteinModelPortaliA6H5Z3
SMRiA6H5Z3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217843, 1 interactor
STRINGi10090.ENSMUSP00000125312

PTM databases

iPTMnetiA6H5Z3
PhosphoSitePlusiA6H5Z3

Proteomic databases

EPDiA6H5Z3
MaxQBiA6H5Z3
PaxDbiA6H5Z3
PeptideAtlasiA6H5Z3
PRIDEiA6H5Z3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769 [A6H5Z3-1]
GeneIDi75914
KEGGimmu:75914
UCSCiuc009cpa.2 mouse [A6H5Z3-1]
uc009cpb.2 mouse [A6H5Z3-2]

Organism-specific databases

CTDi23233
MGIiMGI:1923164 Exoc6b

Phylogenomic databases

eggNOGiKOG2176 Eukaryota
ENOG410XQAE LUCA
GeneTreeiENSGT00390000005739
HOGENOMiHOG000290640
HOVERGENiHBG057543
InParanoidiA6H5Z3
KOiK19985
OMAiRDHYNEV
OrthoDBiEOG091G04HR
TreeFamiTF315199

Miscellaneous databases

ChiTaRSiExoc6b mouse
PROiPR:A6H5Z3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033769 Expressed in 201 organ(s), highest expression level in ear vesicle
ExpressionAtlasiA6H5Z3 baseline and differential
GenevisibleiA6H5Z3 MM

Family and domain databases

InterProiView protein in InterPro
IPR007225 EXOC6/Sec15
PANTHERiPTHR12702 PTHR12702, 1 hit
PfamiView protein in Pfam
PF04091 Sec15, 1 hit
PIRSFiPIRSF025007 Sec15, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXC6B_MOUSE
AccessioniPrimary (citable) accession number: A6H5Z3
Secondary accession number(s): Q3UN15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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