UniProtKB - A6H5Z3 (EXC6B_MOUSE)
Protein
Exocyst complex component 6B
Gene
Exoc6b
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity
GO - Biological processi
- exocytosis Source: GO_Central
- Golgi to plasma membrane transport Source: GO_Central
- vesicle docking involved in exocytosis Source: InterPro
Keywordsi
Biological process | Exocytosis, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Exocyst complex component 6BAlternative name(s): Exocyst complex component Sec15B SEC15-like protein 2 |
Gene namesi | Name:Exoc6b Synonyms:Sec15b, Sec15l2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923164 Exoc6b |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000406778 | 1 – 810 | Exocyst complex component 6BAdd BLAST | 810 |
Proteomic databases
EPDi | A6H5Z3 |
MaxQBi | A6H5Z3 |
PaxDbi | A6H5Z3 |
PeptideAtlasi | A6H5Z3 |
PRIDEi | A6H5Z3 |
PTM databases
iPTMneti | A6H5Z3 |
PhosphoSitePlusi | A6H5Z3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000033769 Expressed in 201 organ(s), highest expression level in ear vesicle |
ExpressionAtlasi | A6H5Z3 baseline and differential |
Genevisiblei | A6H5Z3 MM |
Interactioni
Subunit structurei
The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.By similarity
Protein-protein interaction databases
BioGridi | 217843, 1 interactor |
STRINGi | 10090.ENSMUSP00000125312 |
Structurei
3D structure databases
ProteinModelPortali | A6H5Z3 |
SMRi | A6H5Z3 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 79 – 118 | Sequence analysisAdd BLAST | 40 |
Sequence similaritiesi
Belongs to the SEC15 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2176 Eukaryota ENOG410XQAE LUCA |
GeneTreei | ENSGT00390000005739 |
HOGENOMi | HOG000290640 |
HOVERGENi | HBG057543 |
InParanoidi | A6H5Z3 |
KOi | K19985 |
OMAi | RDHYNEV |
OrthoDBi | 185623at2759 |
TreeFami | TF315199 |
Family and domain databases
InterProi | View protein in InterPro IPR007225 EXOC6/Sec15 |
PANTHERi | PTHR12702 PTHR12702, 1 hit |
Pfami | View protein in Pfam PF04091 Sec15, 1 hit |
PIRSFi | PIRSF025007 Sec15, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: A6H5Z3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MERAKMAEES LETAAEHERI LREIESTDTA CIGPTLRSVY DGEEHGRFME
60 70 80 90 100
KLETRIRNHD REIEKMCNFH YQGFVDSITE LLKVRGEAQK LKNQVTDTNR
110 120 130 140 150
KLQHEGKELV IAMEELKQCR LQQRNISATV DKLMLCLPVL EMYSKLRDQM
160 170 180 190 200
KTKRHYPALK TLEHLEHTYL PQVSHYRFCK VMVDNIPKLR EEIKDVSMSD
210 220 230 240 250
LKDFLESIRK HSDKIGETAM KQAQQQRNLD NIVLQQPRIG SKRKSKKDVY
260 270 280 290 300
TIFDAEVEST SPKSEQDSGI LDVEDEEDDE EVPGAQDLVD FSPVYRCLHI
310 320 330 340 350
YSVLGARETF ENYYRKQRRK QARLVLQPPS NMHETLDGYR KYFNQIVGFF
360 370 380 390 400
VVEDHILHTT QGLVNRAYID ELWEMALSKT IAALRTHSSY CSDPNLVLDL
410 420 430 440 450
KNLIVLFADT LQVYGFPVNQ LFDMLLEIRD QYSETLLKKW AGVFRNILDS
460 470 480 490 500
DNYSPIPVTS EETYKKVVGQ FPFQDIELEK QPFPKKFPFS EFVPKVYNQI
510 520 530 540 550
KEFIYACLKF SEDLHLSSTE VDDMIRKSTN LLLTRTLSNS LQNVIKRKNI
560 570 580 590 600
GLTELVQIII NTTHLEKSCK YLEEFITNIT NVLPETVHTT KLYGTTTFKD
610 620 630 640 650
ARHAAEEEIY TNLNQKIDQF LQLADYDWMT GDLDNKASDY LVDLIAFLRS
660 670 680 690 700
TFAVFTHLPG KVAQTACMSA CKHLATSLMQ LLLEAEVRQL TLGALQQFNL
710 720 730 740 750
DVRECEQFAR SGPVPGFQED TLQLAFIDLR QLLDLFIQWD WSTYLADYGQ
760 770 780 790 800
PNCKYLRVNP VTALTLLEKM KDTSRKNNMF AQFRKNERDK QKLIDTVAKQ
810
LRGLISSHHS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE0CY34 | E0CY34_MOUSE | Exocyst complex component 6B | Exoc6b | 39 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040840 | 660 – 678 | GKVAQ…LATSL → VSDSSSILPFKVGNPCLTL in isoform 2. 2 PublicationsAdd BLAST | 19 | |
Alternative sequenceiVSP_040841 | 679 – 810 | Missing in isoform 2. 2 PublicationsAdd BLAST | 132 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK144547 mRNA Translation: BAE25933.1 CH466523 Genomic DNA Translation: EDK99119.1 BC144781 mRNA Translation: AAI44782.1 BC145693 mRNA Translation: AAI45694.1 |
CCDSi | CCDS51824.1 [A6H5Z3-1] |
RefSeqi | NP_796051.2, NM_177077.2 [A6H5Z3-1] |
UniGenei | Mm.159621 |
Genome annotation databases
Ensembli | ENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769 [A6H5Z3-1] |
GeneIDi | 75914 |
KEGGi | mmu:75914 |
UCSCi | uc009cpa.2 mouse [A6H5Z3-1] uc009cpb.2 mouse [A6H5Z3-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK144547 mRNA Translation: BAE25933.1 CH466523 Genomic DNA Translation: EDK99119.1 BC144781 mRNA Translation: AAI44782.1 BC145693 mRNA Translation: AAI45694.1 |
CCDSi | CCDS51824.1 [A6H5Z3-1] |
RefSeqi | NP_796051.2, NM_177077.2 [A6H5Z3-1] |
UniGenei | Mm.159621 |
3D structure databases
ProteinModelPortali | A6H5Z3 |
SMRi | A6H5Z3 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 217843, 1 interactor |
STRINGi | 10090.ENSMUSP00000125312 |
PTM databases
iPTMneti | A6H5Z3 |
PhosphoSitePlusi | A6H5Z3 |
Proteomic databases
EPDi | A6H5Z3 |
MaxQBi | A6H5Z3 |
PaxDbi | A6H5Z3 |
PeptideAtlasi | A6H5Z3 |
PRIDEi | A6H5Z3 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769 [A6H5Z3-1] |
GeneIDi | 75914 |
KEGGi | mmu:75914 |
UCSCi | uc009cpa.2 mouse [A6H5Z3-1] uc009cpb.2 mouse [A6H5Z3-2] |
Organism-specific databases
CTDi | 23233 |
MGIi | MGI:1923164 Exoc6b |
Phylogenomic databases
eggNOGi | KOG2176 Eukaryota ENOG410XQAE LUCA |
GeneTreei | ENSGT00390000005739 |
HOGENOMi | HOG000290640 |
HOVERGENi | HBG057543 |
InParanoidi | A6H5Z3 |
KOi | K19985 |
OMAi | RDHYNEV |
OrthoDBi | 185623at2759 |
TreeFami | TF315199 |
Miscellaneous databases
ChiTaRSi | Exoc6b mouse |
PROi | PR:A6H5Z3 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033769 Expressed in 201 organ(s), highest expression level in ear vesicle |
ExpressionAtlasi | A6H5Z3 baseline and differential |
Genevisiblei | A6H5Z3 MM |
Family and domain databases
InterProi | View protein in InterPro IPR007225 EXOC6/Sec15 |
PANTHERi | PTHR12702 PTHR12702, 1 hit |
Pfami | View protein in Pfam PF04091 Sec15, 1 hit |
PIRSFi | PIRSF025007 Sec15, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | EXC6B_MOUSE | |
Accessioni | A6H5Z3Primary (citable) accession number: A6H5Z3 Secondary accession number(s): Q3UN15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 5, 2011 |
Last sequence update: | July 24, 2007 | |
Last modified: | January 16, 2019 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot