UniProtKB - A6H5Z3 (EXC6B_MOUSE)

BLAST

>sp|A6H5Z3|EXC6B_MOUSE Exocyst complex component 6B OS=Mus musculus OX=10090 GN=Exoc6b PE=1 SV=1
MERAKMAEESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHD
REIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCR
LQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCK
VMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIVLQQPRIG
SKRKSKKDVYTIFDAEVESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHI
YSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTT
QGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQ
LFDMLLEIRDQYSETLLKKWAGVFRNILDSDNYSPIPVTSEETYKKVVGQFPFQDIELEK
QPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNS
LQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKD
ARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLDNKASDYLVDLIAFLRSTFAVFTHLPG
KVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQED
TLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKMKDTSRKNNMF
AQFRKNERDKQKLIDTVAKQLRGLISSHHS

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History
Entry version 75 (07 Nov 2018)
Sequence version 1 (24 Jul 2007)
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Protein

Exocyst complex component 6B

Gene

Exoc6b

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Biological processⁱ

exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Golgi to plasma membrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle docking involved in exocytosis Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Exocytosis, Transport

Biological process

Exocytosis, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Exocyst complex component 6B Alternative name(s): Exocyst complex component Sec15B SEC15-like protein 2
Gene namesⁱ	Name:Exoc6b Synonyms:Sec15b, Sec15l2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:1923164 Exoc6b

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000406778	1 – 810	Exocyst complex component 6BAdd BLAST		810

Proteomic databases

EPDⁱ	A6H5Z3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6H5Z3
PaxDbⁱ	A6H5Z3
PeptideAtlas More...PeptideAtlasⁱ	A6H5Z3
PRIDEⁱ	A6H5Z3

PTM databases

iPTMnetⁱ	A6H5Z3
PhosphoSitePlusⁱ	A6H5Z3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000033769 Expressed in 201 organ(s), highest expression level in ear vesicle
ExpressionAtlasⁱ	A6H5Z3 baseline and differential
Genevisibleⁱ	A6H5Z3 MM

Interactionⁱ

Subunit structureⁱ

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.By similarity

Protein-protein interaction databases

BioGridⁱ	217843, 1 interactor
STRINGⁱ	10090.ENSMUSP00000125312

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6H5Z3
SMRⁱ	A6H5Z3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	79 – 118	Sequence analysisAdd BLAST		40

Sequence similaritiesⁱ

Belongs to the SEC15 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2176 Eukaryota ENOG410XQAE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005739
HOGENOMⁱ	HOG000290640
HOVERGENⁱ	HBG057543
InParanoidⁱ	A6H5Z3
KEGG Orthology (KO) More...KOⁱ	K19985
OMAⁱ	RDHYNEV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04HR
TreeFamⁱ	TF315199

Family and domain databases

InterProⁱ	View protein in InterPro IPR007225 EXOC6/Sec15
PANTHERⁱ	PTHR12702 PTHR12702, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04091 Sec15, 1 hit
PIRSFⁱ	PIRSF025007 Sec15, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: A6H5Z3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERAKMAEES LETAAEHERI LREIESTDTA CIGPTLRSVY DGEEHGRFME 
        60         70         80         90        100
KLETRIRNHD REIEKMCNFH YQGFVDSITE LLKVRGEAQK LKNQVTDTNR 
       110        120        130        140        150
KLQHEGKELV IAMEELKQCR LQQRNISATV DKLMLCLPVL EMYSKLRDQM 
       160        170        180        190        200
KTKRHYPALK TLEHLEHTYL PQVSHYRFCK VMVDNIPKLR EEIKDVSMSD 
       210        220        230        240        250
LKDFLESIRK HSDKIGETAM KQAQQQRNLD NIVLQQPRIG SKRKSKKDVY 
       260        270        280        290        300
TIFDAEVEST SPKSEQDSGI LDVEDEEDDE EVPGAQDLVD FSPVYRCLHI 
       310        320        330        340        350
YSVLGARETF ENYYRKQRRK QARLVLQPPS NMHETLDGYR KYFNQIVGFF 
       360        370        380        390        400
VVEDHILHTT QGLVNRAYID ELWEMALSKT IAALRTHSSY CSDPNLVLDL 
       410        420        430        440        450
KNLIVLFADT LQVYGFPVNQ LFDMLLEIRD QYSETLLKKW AGVFRNILDS 
       460        470        480        490        500
DNYSPIPVTS EETYKKVVGQ FPFQDIELEK QPFPKKFPFS EFVPKVYNQI 
       510        520        530        540        550
KEFIYACLKF SEDLHLSSTE VDDMIRKSTN LLLTRTLSNS LQNVIKRKNI 
       560        570        580        590        600
GLTELVQIII NTTHLEKSCK YLEEFITNIT NVLPETVHTT KLYGTTTFKD 
       610        620        630        640        650
ARHAAEEEIY TNLNQKIDQF LQLADYDWMT GDLDNKASDY LVDLIAFLRS 
       660        670        680        690        700
TFAVFTHLPG KVAQTACMSA CKHLATSLMQ LLLEAEVRQL TLGALQQFNL 
       710        720        730        740        750
DVRECEQFAR SGPVPGFQED TLQLAFIDLR QLLDLFIQWD WSTYLADYGQ 
       760        770        780        790        800
PNCKYLRVNP VTALTLLEKM KDTSRKNNMF AQFRKNERDK QKLIDTVAKQ 
       810
LRGLISSHHS

Length:810

Mass (Da):94,130

Last modified:July 24, 2007 - v1

Checksum:ⁱ9DC3AA54A4B36084

Isoform 2 (identifier: A6H5Z3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
660-678: GKVAQTACMSACKHLATSL → VSDSSSILPFKVGNPCLTL
679-810: Missing.

« Hide

        10         20         30         40         50
MERAKMAEES LETAAEHERI LREIESTDTA CIGPTLRSVY DGEEHGRFME 
        60         70         80         90        100
KLETRIRNHD REIEKMCNFH YQGFVDSITE LLKVRGEAQK LKNQVTDTNR 
       110        120        130        140        150
KLQHEGKELV IAMEELKQCR LQQRNISATV DKLMLCLPVL EMYSKLRDQM 
       160        170        180        190        200
KTKRHYPALK TLEHLEHTYL PQVSHYRFCK VMVDNIPKLR EEIKDVSMSD 
       210        220        230        240        250
LKDFLESIRK HSDKIGETAM KQAQQQRNLD NIVLQQPRIG SKRKSKKDVY 
       260        270        280        290        300
TIFDAEVEST SPKSEQDSGI LDVEDEEDDE EVPGAQDLVD FSPVYRCLHI 
       310        320        330        340        350
YSVLGARETF ENYYRKQRRK QARLVLQPPS NMHETLDGYR KYFNQIVGFF 
       360        370        380        390        400
VVEDHILHTT QGLVNRAYID ELWEMALSKT IAALRTHSSY CSDPNLVLDL 
       410        420        430        440        450
KNLIVLFADT LQVYGFPVNQ LFDMLLEIRD QYSETLLKKW AGVFRNILDS 
       460        470        480        490        500
DNYSPIPVTS EETYKKVVGQ FPFQDIELEK QPFPKKFPFS EFVPKVYNQI 
       510        520        530        540        550
KEFIYACLKF SEDLHLSSTE VDDMIRKSTN LLLTRTLSNS LQNVIKRKNI 
       560        570        580        590        600
GLTELVQIII NTTHLEKSCK YLEEFITNIT NVLPETVHTT KLYGTTTFKD 
       610        620        630        640        650
ARHAAEEEIY TNLNQKIDQF LQLADYDWMT GDLDNKASDY LVDLIAFLRS 
       660        670 
TFAVFTHLPV SDSSSILPFK VGNPCLTL

Show »

Length:678

Mass (Da):78,803

Checksum:ⁱ612A4740C4C82D12

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E0CY34	E0CY34_MOUSE		Exocyst complex component 6B Exocyst complex component 6B	Exoc6b	39	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040840	660 – 678	GKVAQ…LATSL → VSDSSSILPFKVGNPCLTL in isoform 2. 2 PublicationsAdd BLAST		19
Alternative sequenceⁱVSP_040841	679 – 810	Missing in isoform 2. 2 PublicationsAdd BLAST		132

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK144547 mRNA Translation: BAE25933.1 CH466523 Genomic DNA Translation: EDK99119.1 BC144781 mRNA Translation: AAI44782.1 BC145693 mRNA Translation: AAI45694.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS51824.1 [A6H5Z3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_796051.2, NM_177077.2 [A6H5Z3-1]
UniGeneⁱ	Mm.159621

Genome annotation databases

Ensemblⁱ	ENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769 [A6H5Z3-1]
GeneIDⁱ	75914
KEGGⁱ	mmu:75914
UCSC genome browser More...UCSCⁱ	uc009cpa.2 mouse [A6H5Z3-1] uc009cpb.2 mouse [A6H5Z3-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
A6H5Z3	Exoc6b protein (Fragment)		MOUSE		483	UniRef100_A6H5Z3
UPI0003D792AA		MOUSE		698

Protein	Similar proteins		Species	Score	Length	Source
A6H5Z3	Exocyst complex component 6B		HUMAN		811	UniRef90_Q9Y2D4
Exocyst complex component		PONAB		811
Exocyst complex component		PANPA		811
Exocyst complex component		GORGO		811
Exocyst complex component		DELLE		826
+302
A6H5Z3-2	Isoform 2 of Exocyst complex component 6B		HUMAN		672	UniRef90_Q9Y2D4-2
Exocyst complex component		FELCA		759
Exocyst complex component		DELLE		759
Exocyst complex component		Florida manatee		755
Exocyst complex component		FUKDA		737
+53

Protein	Similar proteins		Species	Score	Length	Source
A6H5Z3	Exocyst complex component 6		HUMAN		804	UniRef50_Q8TAG9
Exocyst complex component 6		RAT		804
Exocyst complex component 6		CANLF		803
Exocyst complex component		CHLSB		843
Exocyst complex component		AOTNA		839
+1177
A6H5Z3-2	Isoform 2 of Exocyst complex component 6B		HUMAN		672	UniRef50_Q9Y2D4-2
Exocyst complex component 6		MOUSE		802
Exocyst complex component		DELLE		759
Exocyst complex component		FELCA		759
Exocyst complex component		Florida manatee		755
+456

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK144547 mRNA Translation: BAE25933.1 CH466523 Genomic DNA Translation: EDK99119.1 BC144781 mRNA Translation: AAI44782.1 BC145693 mRNA Translation: AAI45694.1
CCDSⁱ	CCDS51824.1 [A6H5Z3-1]
RefSeqⁱ	NP_796051.2, NM_177077.2 [A6H5Z3-1]
UniGeneⁱ	Mm.159621

3D structure databases

ProteinModelPortalⁱ	A6H5Z3
SMRⁱ	A6H5Z3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	217843, 1 interactor
STRINGⁱ	10090.ENSMUSP00000125312

PTM databases

iPTMnetⁱ	A6H5Z3
PhosphoSitePlusⁱ	A6H5Z3

Proteomic databases

EPDⁱ	A6H5Z3
MaxQBⁱ	A6H5Z3
PaxDbⁱ	A6H5Z3
PeptideAtlasⁱ	A6H5Z3
PRIDEⁱ	A6H5Z3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769 [A6H5Z3-1]
GeneIDⁱ	75914
KEGGⁱ	mmu:75914
UCSCⁱ	uc009cpa.2 mouse [A6H5Z3-1] uc009cpb.2 mouse [A6H5Z3-2]

Organism-specific databases

CTDⁱ	23233
MGIⁱ	MGI:1923164 Exoc6b

Phylogenomic databases

eggNOGⁱ	KOG2176 Eukaryota ENOG410XQAE LUCA
GeneTreeⁱ	ENSGT00390000005739
HOGENOMⁱ	HOG000290640
HOVERGENⁱ	HBG057543
InParanoidⁱ	A6H5Z3
KOⁱ	K19985
OMAⁱ	RDHYNEV
OrthoDBⁱ	EOG091G04HR
TreeFamⁱ	TF315199

Miscellaneous databases

ChiTaRSⁱ	Exoc6b mouse
Protein Ontology More...PROⁱ	PR:A6H5Z3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000033769 Expressed in 201 organ(s), highest expression level in ear vesicle
ExpressionAtlasⁱ	A6H5Z3 baseline and differential
Genevisibleⁱ	A6H5Z3 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR007225 EXOC6/Sec15
PANTHERⁱ	PTHR12702 PTHR12702, 1 hit
Pfamⁱ	View protein in Pfam PF04091 Sec15, 1 hit
PIRSFⁱ	PIRSF025007 Sec15, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EXC6B_MOUSE
Accessionⁱ	A6H5Z3Primary (citable) accession number: A6H5Z3 Secondary accession number(s): Q3UN15
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
	Last sequence update:	July 24, 2007
	Last modified:	November 7, 2018
	This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - A6H5Z3 (EXC6B_MOUSE)

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Exocyst complex component 6B

Exoc6b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ