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UniProtKB - A6H5Z3 (EXC6B_MOUSE)

Protein

Exocyst complex component 6B

Gene

Exoc6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • exocytosis Source: GO_Central
  • Golgi to plasma membrane transport Source: GO_Central
  • vesicle docking involved in exocytosis Source: InterPro
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 6B
Alternative name(s):
Exocyst complex component Sec15B
SEC15-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Exoc6b
Synonyms:Sec15b, Sec15l2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1923164 Exoc6b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004067781 – 810Exocyst complex component 6BAdd BLAST810

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A6H5Z3

MaxQB - The MaxQuant DataBase

More...MaxQBi		A6H5Z3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A6H5Z3

PeptideAtlas

More...PeptideAtlasi		A6H5Z3

PRoteomics IDEntifications database

More...PRIDEi		A6H5Z3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A6H5Z3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A6H5Z3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000033769 Expressed in 201 organ(s), highest expression level in ear vesicle

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A6H5Z3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A6H5Z3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		217843, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000125312

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		A6H5Z3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A6H5Z3

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili79 – 118Sequence analysisAdd BLAST40

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2176 Eukaryota
ENOG410XQAE LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000290640

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG057543

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A6H5Z3

KEGG Orthology (KO)

More...KOi		K19985

Identification of Orthologs from Complete Genome Data

More...OMAi		RDHYNEV

Database of Orthologous Groups

More...OrthoDBi		185623at2759

TreeFam database of animal gene trees

More...TreeFami		TF315199

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007225 EXOC6/Sec15

The PANTHER Classification System

More...PANTHERi		PTHR12702 PTHR12702, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04091 Sec15, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF025007 Sec15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A6H5Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERAKMAEES LETAAEHERI LREIESTDTA CIGPTLRSVY DGEEHGRFME 
        60         70         80         90        100
KLETRIRNHD REIEKMCNFH YQGFVDSITE LLKVRGEAQK LKNQVTDTNR 
       110        120        130        140        150
KLQHEGKELV IAMEELKQCR LQQRNISATV DKLMLCLPVL EMYSKLRDQM 
       160        170        180        190        200
KTKRHYPALK TLEHLEHTYL PQVSHYRFCK VMVDNIPKLR EEIKDVSMSD 
       210        220        230        240        250
LKDFLESIRK HSDKIGETAM KQAQQQRNLD NIVLQQPRIG SKRKSKKDVY 
       260        270        280        290        300
TIFDAEVEST SPKSEQDSGI LDVEDEEDDE EVPGAQDLVD FSPVYRCLHI 
       310        320        330        340        350
YSVLGARETF ENYYRKQRRK QARLVLQPPS NMHETLDGYR KYFNQIVGFF 
       360        370        380        390        400
VVEDHILHTT QGLVNRAYID ELWEMALSKT IAALRTHSSY CSDPNLVLDL 
       410        420        430        440        450
KNLIVLFADT LQVYGFPVNQ LFDMLLEIRD QYSETLLKKW AGVFRNILDS 
       460        470        480        490        500
DNYSPIPVTS EETYKKVVGQ FPFQDIELEK QPFPKKFPFS EFVPKVYNQI 
       510        520        530        540        550
KEFIYACLKF SEDLHLSSTE VDDMIRKSTN LLLTRTLSNS LQNVIKRKNI 
       560        570        580        590        600
GLTELVQIII NTTHLEKSCK YLEEFITNIT NVLPETVHTT KLYGTTTFKD 
       610        620        630        640        650
ARHAAEEEIY TNLNQKIDQF LQLADYDWMT GDLDNKASDY LVDLIAFLRS 
       660        670        680        690        700
TFAVFTHLPG KVAQTACMSA CKHLATSLMQ LLLEAEVRQL TLGALQQFNL 
       710        720        730        740        750
DVRECEQFAR SGPVPGFQED TLQLAFIDLR QLLDLFIQWD WSTYLADYGQ 
       760        770        780        790        800
PNCKYLRVNP VTALTLLEKM KDTSRKNNMF AQFRKNERDK QKLIDTVAKQ 
       810
LRGLISSHHS
Length:810
Mass (Da):94,130
Last modified:July 24, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DC3AA54A4B36084
GO
Isoform 2 (identifier: A6H5Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-678: GKVAQTACMSACKHLATSL → VSDSSSILPFKVGNPCLTL
     679-810: Missing.

Show »
Length:678
Mass (Da):78,803
Checksum:i612A4740C4C82D12
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CY34E0CY34_MOUSE
Exocyst complex component 6B
Exoc6b
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040840660 – 678GKVAQ…LATSL → VSDSSSILPFKVGNPCLTL in isoform 2. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_040841679 – 810Missing in isoform 2. 2 PublicationsAdd BLAST132

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK144547 mRNA Translation: BAE25933.1
CH466523 Genomic DNA Translation: EDK99119.1
BC144781 mRNA Translation: AAI44782.1
BC145693 mRNA Translation: AAI45694.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS51824.1 [A6H5Z3-1]

NCBI Reference Sequences

More...RefSeqi		NP_796051.2, NM_177077.2 [A6H5Z3-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.159621

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769 [A6H5Z3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		75914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:75914

UCSC genome browser

More...UCSCi		uc009cpa.2 mouse [A6H5Z3-1]
uc009cpb.2 mouse [A6H5Z3-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144547 mRNA Translation: BAE25933.1
CH466523 Genomic DNA Translation: EDK99119.1
BC144781 mRNA Translation: AAI44782.1
BC145693 mRNA Translation: AAI45694.1
CCDSiCCDS51824.1 [A6H5Z3-1]
RefSeqiNP_796051.2, NM_177077.2 [A6H5Z3-1]
UniGeneiMm.159621

3D structure databases

ProteinModelPortaliA6H5Z3
SMRiA6H5Z3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217843, 1 interactor
STRINGi10090.ENSMUSP00000125312

PTM databases

iPTMnetiA6H5Z3
PhosphoSitePlusiA6H5Z3

Proteomic databases

EPDiA6H5Z3
MaxQBiA6H5Z3
PaxDbiA6H5Z3
PeptideAtlasiA6H5Z3
PRIDEiA6H5Z3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160197; ENSMUSP00000125312; ENSMUSG00000033769 [A6H5Z3-1]
GeneIDi75914
KEGGimmu:75914
UCSCiuc009cpa.2 mouse [A6H5Z3-1]
uc009cpb.2 mouse [A6H5Z3-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23233
MGIiMGI:1923164 Exoc6b

Phylogenomic databases

eggNOGiKOG2176 Eukaryota
ENOG410XQAE LUCA
GeneTreeiENSGT00390000005739
HOGENOMiHOG000290640
HOVERGENiHBG057543
InParanoidiA6H5Z3
KOiK19985
OMAiRDHYNEV
OrthoDBi185623at2759
TreeFamiTF315199

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Exoc6b mouse

Protein Ontology

More...PROi		PR:A6H5Z3

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000033769 Expressed in 201 organ(s), highest expression level in ear vesicle
ExpressionAtlasiA6H5Z3 baseline and differential
GenevisibleiA6H5Z3 MM

Family and domain databases

InterProiView protein in InterPro
IPR007225 EXOC6/Sec15
PANTHERiPTHR12702 PTHR12702, 1 hit
PfamiView protein in Pfam
PF04091 Sec15, 1 hit
PIRSFiPIRSF025007 Sec15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXC6B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6H5Z3
Secondary accession number(s): Q3UN15
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 24, 2007
Last modified: January 16, 2019
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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