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Protein

Collagen alpha-5(VI) chain

Gene

Col6a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Collagen VI acts as a cell-binding protein.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-5(VI) chain
Alternative name(s):
Collagen alpha-1(XXIX) chain
Gene namesi
Name:Col6a5
Synonyms:Col29a1, Gm7455
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3648134 Col6a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500025301019 – 2640Collagen alpha-5(VI) chainAdd BLAST2622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi614N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2541N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiA6H584
PeptideAtlasiA6H584
PRIDEiA6H584

PTM databases

iPTMnetiA6H584
PhosphoSitePlusiA6H584

Expressioni

Tissue specificityi

In newborn, it is expressed in lung, heart, kidney, muscle, brain, intestine, skin, femur, sternum and calvaria. In adult, it is widely expressed and is detected in lung, heart, kidney, spleen, muscle, ovary, uterus, brain, skin, liver and sternum.1 Publication

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131146

Structurei

3D structure databases

SMRiA6H584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 209VWFA 1PROSITE-ProRule annotationAdd BLAST180
Domaini268 – 445VWFA 2PROSITE-ProRule annotationAdd BLAST178
Domaini474 – 644VWFA 3PROSITE-ProRule annotationAdd BLAST171
Domaini660 – 829VWFA 4PROSITE-ProRule annotationAdd BLAST170
Domaini846 – 1023VWFA 5PROSITE-ProRule annotationAdd BLAST178
Domaini1037 – 1214VWFA 6PROSITE-ProRule annotationAdd BLAST178
Domaini1226 – 1413VWFA 7PROSITE-ProRule annotationAdd BLAST188
Domaini1426 – 1478Collagen-like 1Sequence analysisAdd BLAST53
Domaini1474 – 1524Collagen-like 2Sequence analysisAdd BLAST51
Domaini1557 – 1614Collagen-like 3Sequence analysisAdd BLAST58
Domaini1632 – 1689Collagen-like 4Sequence analysisAdd BLAST58
Domaini1706 – 1762Collagen-like 5Sequence analysisAdd BLAST57
Domaini1790 – 1970VWFA 8PROSITE-ProRule annotationAdd BLAST181
Domaini1996 – 2186VWFA 9PROSITE-ProRule annotationAdd BLAST191
Domaini2321 – 2516VWFA 10PROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 1426Nonhelical regionAdd BLAST1408
Regioni1427 – 1760Triple-helical regionAdd BLAST334
Regioni1761 – 2640Nonhelical regionAdd BLAST880

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1649 – 1651Cell attachment siteSequence analysis3
Motifi2216 – 2218Cell attachment siteSequence analysis3
Motifi2259 – 2261Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the type VI collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
HOVERGENiHBG107743
InParanoidiA6H584
KOiK06238
TreeFamiTF318242

Family and domain databases

Gene3Di3.40.50.410, 9 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00092 VWA, 9 hits
SMARTiView protein in SMART
SM00327 VWA, 9 hits
SUPFAMiSSF53300 SSF53300, 10 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A6H584-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLRLIAFVL ILWTETLADQ SPGPGPEYAD VVFLVDSSNY LGIKSFPFVR
60 70 80 90 100
TFLNRMISSL PIEANKYRVA LAQYSDALHN EFQLGTFKNR NPMLNHLKKN
110 120 130 140 150
FGFIGGSLKI GNALQEAHRT YFSAPTNGRD KKQFPPILVV LASAESEDDV
160 170 180 190 200
EEAAKALRED GVKIISVGVQ KASEENLKAM ATSQFHFNLR TARDLGMFAP
210 220 230 240 250
NMTRIIKDVT QYREGTTVDL ITAVAPTTPA APATPAAPTI PAALTTAANH
260 270 280 290 300
VDKTVPFPTS CQKDSLADLI FLVDESVGTT QNLRDLQNFL ENVTSSVDVK
310 320 330 340 350
DNCMRLGLMS FSDRAQTISS LRSSANQSEF QQQIQKLSLQ TGASNVGAAI
360 370 380 390 400
EQMRKEGFSE SSGSRKAQGV PQIAVLVTHR ASDDMVREAA LDLRLEGVTM
410 420 430 440 450
FAMGIEGANN TQLEDIVSYP SRQSISTHSS YSHLESYSGN FLKKIRNEIW
460 470 480 490 500
TQVSTRAEQM ELDKTGCVDT KEADIYFLID GSSSIRKKEF EQIQIFMSSV
510 520 530 540 550
IDMFPIGPNK VRVGVVQYSH KNEVEFPVSR YTDGIDLKKA VFNIKQLKGL
560 570 580 590 600
TFTGKALDFI LPLIKKGKTE RTDRAPCYLI VLTDGKSNDS VLEPANRLRA
610 620 630 640 650
EQITIHAIGI GEANKTQLRQ IAGKDERVNF GQNFDSLKSI KNEIVHRICS
660 670 680 690 700
EKGCEDMKAD IMFLVDSSGS IGPTNFETMK TFMKNLVGKI QIGADRSQVG
710 720 730 740 750
VVQFSDYNRE EFQLNKYSTH EEIYAAIDRM SPINRNTLTG GALTFVNEYF
760 770 780 790 800
DLSKGGRPQV RKFLILLTDG KAQDEVGGPA TALRSKSVTI FSVGVYGANR
810 820 830 840 850
AQLEEISGDG SLVFHVENFD HLKAIESKLI FRVCALHDCK RIELLDIVFV
860 870 880 890 900
LDHSGSIGPR EQESMMNLTI HLVKKADVGR DRVQIGALTY SNHPEILFYL
910 920 930 940 950
NTYSSGSAIA EHLRRPRDTG GETYTAKALQ HSNVLFTEEH GSRLTQNVRQ
960 970 980 990 1000
LMIVITDGVS HDRDKLDEAA RELRDKGITI FAVGVGNANQ DELETMAGKK
1010 1020 1030 1040 1050
ENTVHVDNFD KLRDIYLPLQ ETLCNNSQET CNLPEADVIF LCDGSDMVSD
1060 1070 1080 1090 1100
SEFVTMTTFL SDLIDNFDIE SQRMKIGMAQ YGSRYQEIIE LESSLNKTQW
1110 1120 1130 1140 1150
KSQVHSVAQS KGLPRLDFAL KHVSDMFDPS VGGRRNAGVP QTLVVITSSS
1160 1170 1180 1190 1200
PRYDVTDAVK VLKDLGICVL ALGIGDVYKE QLLPITGNSE KIITFRDFNK
1210 1220 1230 1240 1250
LKNVDVKKRM VREICQSCGK ANCFVDVVVG FDISTHRQGQ PLFQGHPRLE
1260 1270 1280 1290 1300
SYLPGILEDI TSIRGVSCGA GAEAQVSLAF KVNSDQEFPA KFQIYQKAAF
1310 1320 1330 1340 1350
DSLLHVTVRG PTHLDAPFLQ SLWDMFEERS ASRGQVLLIF SDGLQGESIT
1360 1370 1380 1390 1400
LLERQSDRLR EAGLDALLVV SLNTFGHDEF SSFEFGKGFD YRTQLTIGML
1410 1420 1430 1440 1450
DLGKTLSQYL GNIAERACCC TFCKCPGIPG PHGTRGLQAS KGSSGPKGSR
1460 1470 1480 1490 1500
GHRGEDGDPG RRGEIGLQGD RGVVGCPGTR GQKGVKGFSG AQGEHGEDGL
1510 1520 1530 1540 1550
DGLDGEEGFY GFRGGKGQKG DPGNQGYPGI RGAAGEDGEK GFPGDPGDPG
1560 1570 1580 1590 1600
KDSNIKGQKG EKGERGRQGI TGQKGTHGRP SSKGSRGMEG QRGPQGPSGQ
1610 1620 1630 1640 1650
AGNPGPQGTQ GPEGLQGSQG SSGNRGGKGD KGSQGYQGPQ GSPGPAGPRG
1660 1670 1680 1690 1700
DIGRPGFGGR KGEPGVPGGP GPVGPPGQRG KQGDYGIPGY GQTGRKGVKG
1710 1720 1730 1740 1750
PTGFPGDPGQ KGDAGNPGIP GGPGPKGFKG LTLSQGLKGR SGLQGSQGPP
1760 1770 1780 1790 1800
GRRGPKGTAG QPIYSPCELI QFLRDHSLIF TDKCPVYPTE LVFALDQSSG
1810 1820 1830 1840 1850
ITERRFNETR DTITSIVSDL NIRENNCPVG ARVAVVSYDS DTSYLIRGSD
1860 1870 1880 1890 1900
YHNKKHLLQL LSQIKYQVPR KARDIGNAMR FVARNVFKRM SAGTNTRRVA
1910 1920 1930 1940 1950
VFFSNGQAAS RASILTATME LSALDISLAV FAYNERVFLD EAFGFDDTGT
1960 1970 1980 1990 2000
FQVIPVPPVG DYEPLEKLRR CTLCYDKCFP NTCAEEPFFP ENSYMDVAFL
2010 2020 2030 2040 2050
LDNSKNIASD DFQAVKALVS SVIDSFHITS NPSASESGDR VALLSYSPSE
2060 2070 2080 2090 2100
SSRRKGRVKT EFAFTTYDNQ SIMKNYIYTS LQQLNGDATI GLALQWAMEG
2110 2120 2130 2140 2150
LFLGTPNPRK HKVIIVISAG ENHEEKEFVK TVALRAKCQG YVVFVISLGS
2160 2170 2180 2190 2200
TQRDEMEELA SYPLDHHLIQ LGRMYKPDLN YIVKFLKPFI YSVRRGFNQY
2210 2220 2230 2240 2250
PPPTLKDDCR LVELERGDTL PHGLRLTAKL REVPESTISL ADQELNAGKD
2260 2270 2280 2290 2300
SSFVLEDHRG DHLVYVPSQM LEPHKLVSHY GNDRESVAMA SLTSEHESHG
2310 2320 2330 2340 2350
REELGLAHEP GDASLQEYYM DVAFLIDASQ RVGGRNEFKE VRTLITSVLD
2360 2370 2380 2390 2400
YFHIAPAPLT SVLGDRVAVL TYSPPGYLPN TEECPVYLEF DLVTYNTVHQ
2410 2420 2430 2440 2450
MKHHLQESLQ QLNGDVFIGH ALQWTVDNVF VGTPNLRKNK VIFIVTAGET
2460 2470 2480 2490 2500
NPLDKEVLRN ASLRAKCQGY SIFVFSFGPI HNDMELEELA SHPLDHHLVR
2510 2520 2530 2540 2550
LGRVHRPDLD YVIKFIKPFV HSIRRAINKY PGRDLQAKCD NLTFPGPENA
2560 2570 2580 2590 2600
GTEDSALLIP EVYRIEAGEN ELSGDSGSQE QHFFLLGNSH GNHSESTADL
2610 2620 2630 2640
MRQLYLLLSS GELMVNDKEE PCSAETPAPV NSKQDGEDAR
Length:2,640
Mass (Da):289,575
Last modified:April 29, 2015 - v4
Checksum:i710C3761FF672ACA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8W1A0A140T8W1_MOUSE
Collagen alpha-5(VI) chain
Col6a5
2,640Annotation score:
A0A140T8T7A0A140T8T7_MOUSE
Collagen alpha-5(VI) chain
Col6a5
2,640Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1483K → E in CAO01892 (PubMed:18276594).Curated1
Sequence conflicti1778 – 1781LIFT → PCWK in CAO01892 (PubMed:18276594).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM748256 mRNA Translation: CAO01891.1
AM748257 mRNA Translation: CAO01892.1
AM748258 mRNA Translation: CAO01893.1
AC119951 Genomic DNA No translation available.
AC120386 Genomic DNA No translation available.
CCDSiCCDS85720.1
RefSeqiNP_001161395.1, NM_001167923.1
UniGeneiMm.39826

Genome annotation databases

GeneIDi665033
KEGGimmu:665033

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM748256 mRNA Translation: CAO01891.1
AM748257 mRNA Translation: CAO01892.1
AM748258 mRNA Translation: CAO01893.1
AC119951 Genomic DNA No translation available.
AC120386 Genomic DNA No translation available.
CCDSiCCDS85720.1
RefSeqiNP_001161395.1, NM_001167923.1
UniGeneiMm.39826

3D structure databases

SMRiA6H584
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131146

PTM databases

iPTMnetiA6H584
PhosphoSitePlusiA6H584

Proteomic databases

PaxDbiA6H584
PeptideAtlasiA6H584
PRIDEiA6H584

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi665033
KEGGimmu:665033

Organism-specific databases

CTDi256076
MGIiMGI:3648134 Col6a5

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
HOVERGENiHBG107743
InParanoidiA6H584
KOiK06238
TreeFamiTF318242

Miscellaneous databases

PROiPR:A6H584
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.410, 9 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00092 VWA, 9 hits
SMARTiView protein in SMART
SM00327 VWA, 9 hits
SUPFAMiSSF53300 SSF53300, 10 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCO6A5_MOUSE
AccessioniPrimary (citable) accession number: A6H584
Secondary accession number(s): A6H585, A6H586, E9Q1B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 29, 2015
Last modified: November 7, 2018
This is version 75 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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