UniProtKB - A6H294 (HFLX_FLAPJ)
Protein
GTPase HflX
Gene
hflX
Organism
Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86)
Status
Functioni
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 213 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 233 | MagnesiumUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 206 – 213 | GTPUniRule annotation | 8 | |
Nucleotide bindingi | 231 – 235 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 252 – 255 | GTPUniRule annotation | 4 | |
Nucleotide bindingi | 318 – 321 | GTPUniRule annotation | 4 | |
Nucleotide bindingi | 364 – 366 | GTPUniRule annotation | 3 |
GO - Molecular functioni
- GTPase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | FPSY402612:G1GJP-2568-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase HflXUniRule annotationAlternative name(s): GTP-binding protein HflXUniRule annotation |
Gene namesi | Name:hflXUniRule annotation Ordered Locus Names:FP2414 |
Organismi | Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86) |
Taxonomic identifieri | 402612 [NCBI] |
Taxonomic lineagei | Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Note: May associate with membranes.UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000412657 | 1 – 413 | GTPase HflXAdd BLAST | 413 |
Interactioni
Subunit structurei
Monomer. Associates with the 50S ribosomal subunit.
UniRule annotationProtein-protein interaction databases
STRINGi | 402612.FP2414 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 200 – 386 | Hflx-type GUniRule annotationAdd BLAST | 187 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG2262, Bacteria |
HOGENOMi | CLU_019597_2_1_10 |
OMAi | VELAQYE |
Family and domain databases
CDDi | cd01878, HflX, 1 hit |
Gene3Di | 3.40.50.11060, 1 hit |
HAMAPi | MF_00900, GTPase_HflX, 1 hit |
InterProi | View protein in InterPro IPR030394, G_HFLX_dom IPR006073, GTP-bd IPR032305, GTP-bd_M IPR016496, GTPase_HflX IPR025121, GTPase_HflX_N IPR042108, GTPase_HflX_N_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR10229, PTHR10229, 1 hit |
Pfami | View protein in Pfam PF16360, GTP-bdg_M, 1 hit PF13167, GTP-bdg_N, 1 hit PF01926, MMR_HSR1, 1 hit |
PIRSFi | PIRSF006809, GTP-binding_hflX_prd, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03156, GTP_HflX, 1 hit |
PROSITEi | View protein in PROSITE PS51705, G_HFLX, 1 hit |
i Sequence
Sequence statusi: Complete.
A6H294-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLEKETINFE KTIIVGIVTQ NQSEEKLKEY LDELEFLTFT AGGEVVKRFS
60 70 80 90 100
QKMERPNPKT FLGTGKIEEI NLYVLENGIS TIVFDDELTP SQQKNISKII
110 120 130 140 150
DCKILDRTHL ILDIFAQRAE TSYARTQVEL AQCIYLLPRL SGMWTHLERQ
160 170 180 190 200
KGGIGMRGPG ETEIETDRRI VRDRIALLKE KIKIIDKQQA TQRGNRGAMV
210 220 230 240 250
RVALVGYTNV GKSTLMNAVG KSDVFVENKL FATLDTTVRK VVIKNLPFLL
260 270 280 290 300
SDTVGFIRKL PTQLVDSFKS TLDEVREADL LLHVVDISHQ DFEDHIDAVN
310 320 330 340 350
KILLDIKSAD KPTIMVFNKI DAYKHLTIDA DDLMTERTSK HYTLQEWKNT
360 370 380 390 400
WMNKVGEQNA LFISATNKEN FEEFRKKVYE TVREIHITRF PYNKFLYPDY
410
EDAIDKEEEQ DQD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM398681 Genomic DNA Translation: CAL44468.1 |
RefSeqi | WP_011964502.1, NC_009613.3 YP_001297269.1, NC_009613.3 |
Genome annotation databases
EnsemblBacteriai | CAL44468; CAL44468; FP2414 |
GeneIDi | 56831422 |
KEGGi | fps:FP2414 |
PATRICi | fig|402612.5.peg.2470 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM398681 Genomic DNA Translation: CAL44468.1 |
RefSeqi | WP_011964502.1, NC_009613.3 YP_001297269.1, NC_009613.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 402612.FP2414 |
Genome annotation databases
EnsemblBacteriai | CAL44468; CAL44468; FP2414 |
GeneIDi | 56831422 |
KEGGi | fps:FP2414 |
PATRICi | fig|402612.5.peg.2470 |
Phylogenomic databases
eggNOGi | COG2262, Bacteria |
HOGENOMi | CLU_019597_2_1_10 |
OMAi | VELAQYE |
Enzyme and pathway databases
BioCyci | FPSY402612:G1GJP-2568-MONOMER |
Family and domain databases
CDDi | cd01878, HflX, 1 hit |
Gene3Di | 3.40.50.11060, 1 hit |
HAMAPi | MF_00900, GTPase_HflX, 1 hit |
InterProi | View protein in InterPro IPR030394, G_HFLX_dom IPR006073, GTP-bd IPR032305, GTP-bd_M IPR016496, GTPase_HflX IPR025121, GTPase_HflX_N IPR042108, GTPase_HflX_N_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR10229, PTHR10229, 1 hit |
Pfami | View protein in Pfam PF16360, GTP-bdg_M, 1 hit PF13167, GTP-bdg_N, 1 hit PF01926, MMR_HSR1, 1 hit |
PIRSFi | PIRSF006809, GTP-binding_hflX_prd, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03156, GTP_HflX, 1 hit |
PROSITEi | View protein in PROSITE PS51705, G_HFLX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HFLX_FLAPJ | |
Accessioni | A6H294Primary (citable) accession number: A6H294 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 21, 2011 |
Last sequence update: | July 24, 2007 | |
Last modified: | April 7, 2021 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families