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Protein

ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

nnrD

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH.UniRule annotation
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei221NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi192 – 196ADPUniRule annotation5
Nucleotide bindingi211 – 220ADPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciFPSY402612:G1GJP-959-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.136UniRule annotation)
Alternative name(s):
ADP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
Name:nnrDUniRule annotation
Ordered Locus Names:FP0837
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006394 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161421 – 282ADP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST282

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi402612.FP0837

Structurei

3D structure databases

ProteinModelPortaliA6GXW4
SMRiA6GXW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 280YjeF C-terminalUniRule annotationAdd BLAST273

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 163NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DR1 Bacteria
COG0063 LUCA
HOGENOMiHOG000024581
KOiK17758
OMAiNLMVHPL
OrthoDBiPOG091H01XZ

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

A6GXW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDFCQIDTQ EIIKRYKPID KYTHKGLQGH ALIIGGSYGK MGSVVLASKA
60 70 80 90 100
CIRSGAGLVT AYIPKCGCDI VQISVPEVMV ITDDYLEHIA LINFDLNLKS
110 120 130 140 150
IGIGVGMGQH PDTQHAFFNF LKSNKLPLVI DADALNILSQ NIEWLSLLPK
160 170 180 190 200
KAILTPHQKE LERLIGKWSS EEEKLEKVKR LCLEYDLIFV LKGAPTMIVN
210 220 230 240 250
NKSTYENTTG NQALATAGSG DVLAGIITSL LAQSYEPINA AIIGVYLHGL
260 270 280
TADIAYPKVG YQSFIASDII ETLGEAYLHI IK
Length:282
Mass (Da):30,918
Last modified:July 24, 2007 - v1
Checksum:i21DB3A1D5AAAF34D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM398681 Genomic DNA Translation: CAL42937.1
RefSeqiWP_011962993.1, NC_009613.3
YP_001295753.1, NC_009613.3

Genome annotation databases

EnsemblBacteriaiCAL42937; CAL42937; FP0837
GeneIDi5300559
KEGGifps:FP0837
PATRICifig|402612.5.peg.850

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM398681 Genomic DNA Translation: CAL42937.1
RefSeqiWP_011962993.1, NC_009613.3
YP_001295753.1, NC_009613.3

3D structure databases

ProteinModelPortaliA6GXW4
SMRiA6GXW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402612.FP0837

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL42937; CAL42937; FP0837
GeneIDi5300559
KEGGifps:FP0837
PATRICifig|402612.5.peg.850

Phylogenomic databases

eggNOGiENOG4105DR1 Bacteria
COG0063 LUCA
HOGENOMiHOG000024581
KOiK17758
OMAiNLMVHPL
OrthoDBiPOG091H01XZ

Enzyme and pathway databases

BioCyciFPSY402612:G1GJP-959-MONOMER

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNNRD_FLAPJ
AccessioniPrimary (citable) accession number: A6GXW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: July 24, 2007
Last modified: October 10, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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