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Entry version 104 (08 May 2019)
Sequence version 3 (24 Mar 2009)
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Protein

Multiple epidermal growth factor-like domains protein 11

Gene

MEGF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 11
Short name:
Multiple EGF-like domains protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEGF11
Synonyms:KIAA1781
ORF Names:UNQ1949/PRO4432
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29635 MEGF11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612454 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A6BM72

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 848ExtracellularSequence analysisAdd BLAST829
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei849 – 869HelicalSequence analysisAdd BLAST21
Topological domaini870 – 1044CytoplasmicSequence analysisAdd BLAST175

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84465

Open Targets

More...
OpenTargetsi
ENSG00000157890

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596411

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MEGF11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030973520 – 1044Multiple epidermal growth factor-like domains protein 11Add BLAST1025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 89Sequence analysis
Disulfide bondi54 ↔ 63Sequence analysis
Disulfide bondi88 ↔ 99Sequence analysis
Disulfide bondi103 ↔ 118By similarity
Disulfide bondi120 ↔ 129By similarity
Disulfide bondi146 ↔ 154By similarity
Disulfide bondi148 ↔ 161By similarity
Disulfide bondi163 ↔ 172By similarity
Disulfide bondi185 ↔ 197By similarity
Disulfide bondi191 ↔ 204By similarity
Disulfide bondi206 ↔ 215By similarity
Disulfide bondi228 ↔ 240By similarity
Disulfide bondi234 ↔ 247By similarity
Disulfide bondi249 ↔ 258By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi271 ↔ 283By similarity
Disulfide bondi277 ↔ 290By similarity
Disulfide bondi292 ↔ 301By similarity
Disulfide bondi314 ↔ 326By similarity
Disulfide bondi320 ↔ 333By similarity
Disulfide bondi335 ↔ 344By similarity
Disulfide bondi403 ↔ 415By similarity
Disulfide bondi409 ↔ 422By similarity
Disulfide bondi424 ↔ 433By similarity
Disulfide bondi446 ↔ 458By similarity
Disulfide bondi452 ↔ 465By similarity
Disulfide bondi467 ↔ 476By similarity
Disulfide bondi493 ↔ 501By similarity
Disulfide bondi495 ↔ 508By similarity
Disulfide bondi510 ↔ 519By similarity
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi575 ↔ 587By similarity
Disulfide bondi581 ↔ 594By similarity
Disulfide bondi596 ↔ 605By similarity
Disulfide bondi663 ↔ 675By similarity
Disulfide bondi669 ↔ 682By similarity
Disulfide bondi684 ↔ 693By similarity
Disulfide bondi710 ↔ 718By similarity
Disulfide bondi712 ↔ 725By similarity
Disulfide bondi727 ↔ 736By similarity
Disulfide bondi753 ↔ 761By similarity
Disulfide bondi755 ↔ 768By similarity
Disulfide bondi770 ↔ 779By similarity
Disulfide bondi792 ↔ 804By similarity
Disulfide bondi798 ↔ 811By similarity
Disulfide bondi813 ↔ 822By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6BM72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6BM72

PRoteomics IDEntifications database

More...
PRIDEi
A6BM72

ProteomicsDB human proteome resource

More...
ProteomicsDBi
769
770 [A6BM72-2]
771 [A6BM72-3]
772 [A6BM72-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
A6BM72-3 [A6BM72-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6BM72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6BM72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157890 Expressed in 121 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6BM72 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6BM72 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017982

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homopolymer (Probable). Does not interact with MEGF10.Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124098, 2 interactors

Protein interaction database and analysis system

More...
IntActi
A6BM72, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386908

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6BM72

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 101EMIPROSITE-ProRule annotationAdd BLAST78
Domaini95 – 130EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini143 – 173EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini181 – 216EGF-like 3PROSITE-ProRule annotationAdd BLAST36
Domaini224 – 259EGF-like 4PROSITE-ProRule annotationAdd BLAST36
Domaini267 – 302EGF-like 5PROSITE-ProRule annotationAdd BLAST36
Domaini310 – 345EGF-like 6PROSITE-ProRule annotationAdd BLAST36
Domaini399 – 434EGF-like 7PROSITE-ProRule annotationAdd BLAST36
Domaini442 – 477EGF-like 8PROSITE-ProRule annotationAdd BLAST36
Domaini490 – 520EGF-like 9PROSITE-ProRule annotationAdd BLAST31
Domaini571 – 606EGF-like 10PROSITE-ProRule annotationAdd BLAST36
Domaini659 – 694EGF-like 11PROSITE-ProRule annotationAdd BLAST36
Domaini707 – 737EGF-like 12PROSITE-ProRule annotationAdd BLAST31
Domaini750 – 780EGF-like 13PROSITE-ProRule annotationAdd BLAST31
Domaini788 – 823EGF-like 14PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MEGF family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1218 Eukaryota
ENOG410XQWV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155333

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294130

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6BM72

Database of Orthologous Groups

More...
OrthoDBi
561378at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6BM72

TreeFam database of animal gene trees

More...
TreeFami
TF332598

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR011489 EMI_domain
IPR002049 Laminin_EGF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12661 hEGF, 3 hits
PF00053 Laminin_EGF, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 17 hits
SM00180 EGF_Lam, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 17 hits
PS01186 EGF_2, 17 hits
PS50026 EGF_3, 14 hits
PS51041 EMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A6BM72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLSLTGLIA FSFLQATLAL NPEDPNVCSH WESYAVTVQE SYAHPFDQIY
60 70 80 90 100
YTRCTDILNW FKCTRHRISY KTAYRRGLRT MYRRRSQCCP GYYESGDFCI
110 120 130 140 150
PLCTEECVHG RCVSPDTCHC EPGWGGPDCS SGCDSDHWGP HCSNRCQCQN
160 170 180 190 200
GALCNPITGA CVCAAGFRGW RCEELCAPGT HGKGCQLPCQ CRHGASCDPR
210 220 230 240 250
AGECLCAPGY TGVYCEELCP PGSHGAHCEL RCPCQNGGTC HHITGECACP
260 270 280 290 300
PGWTGAVCAQ PCPPGTFGQN CSQDCPCHHG GQCDHVTGQC HCTAGYMGDR
310 320 330 340 350
CQEECPFGSF GFQCSQHCDC HNGGQCSPTT GACECEPGYK GPRCQERLCP
360 370 380 390 400
EGLHGPGCTL PCPCDADNTI SCHPVTGACT CQPGWSGHHC NESCPVGYYG
410 420 430 440 450
DGCQLPCTCQ NGADCHSITG GCTCAPGFMG EVCAVSCAAG TYGPNCSSIC
460 470 480 490 500
SCNNGGTCSP VDGSCTCKEG WQGLDCTLPC PSGTWGLNCN ESCTCANGAA
510 520 530 540 550
CSPIDGSCSC TPGWLGDTCE LPCPDGTFGL NCSEHCDCSH ADGCDPVTGH
560 570 580 590 600
CCCLAGWTGI RCDSTCPPGR WGPNCSVSCS CENGGSCSPE DGSCECAPGF
610 620 630 640 650
RGPLCQRICP PGFYGHGCAQ PCPLCVHSSR PCHHISGICE CLPGFSGALC
660 670 680 690 700
NQVCAGGYFG QDCAQLCSCA NNGTCSPIDG SCQCFPGWIG KDCSQACPPG
710 720 730 740 750
FWGPACFHAC SCHNGASCSA EDGACHCTPG WTGLFCTQRC PAAFFGKDCG
760 770 780 790 800
RVCQCQNGAS CDHISGKCTC RTGFTGQHCE QRCAPGTFGY GCQQLCECMN
810 820 830 840 850
NSTCDHVTGT CYCSPGFKGI RCDQAALMME ELNPYTKISP ALGAERHSVG
860 870 880 890 900
AVTGIMLLLF LIVVLLGLFA WHRRRQKEKG RDLAPRVSYT PAMRMTSTDY
910 920 930 940 950
SLSGACGMDR RQNTYIMDKG FKDYMKESVC SSSTCSLNSS ENPYATIKDP
960 970 980 990 1000
PILTCKLPES SYVEMKSPVH MGSPYTDVPS LSTSNKNIYE VEPTVSVVQE
1010 1020 1030 1040
GCGHNSSYIQ NAYDLPRNSH IPGHYDLLPV RQSPANGPSQ DKQS
Length:1,044
Mass (Da):110,844
Last modified:March 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F4CF00B8B1DFCA2
GO
Isoform 2 (identifier: A6BM72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     76-101: RGLRTMYRRRSQCCPGYYESGDFCIP → MHTPSIRSITHDAQTSSTGSSAPGTA

Show »
Length:969
Mass (Da):101,548
Checksum:i33A607F53A94122C
GO
Isoform 3 (identifier: A6BM72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     740-875: CPAAFFGKDC...LGLFAWHRRR → KPHLLASQPL...AMGVSSYVSA
     876-1044: Missing.

Show »
Length:875
Mass (Da):91,433
Checksum:i3E0C7349059398BE
GO
Isoform 4 (identifier: A6BM72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-827: Missing.
     904-964: GACGMDRRQN...CKLPESSYVE → ASTTPWWPVM...GQVPARGLLH
     965-1044: Missing.

Show »
Length:137
Mass (Da):15,467
Checksum:i38E532CEC65E3CD5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS64A0A0A0MS64_HUMAN
Multiple epidermal growth factor-li...
MEGF11
1,140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JN40A0A0G2JN40_HUMAN
Multiple epidermal growth factor-li...
MEGF11
903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLW8A0A0G2JLW8_HUMAN
Multiple epidermal growth factor-li...
MEGF11
828Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYE7C9JYE7_HUMAN
Multiple epidermal growth factor-li...
MEGF11
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR81H3BR81_HUMAN
Multiple epidermal growth factor-li...
MEGF11
579Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMV8A0A0G2JMV8_HUMAN
Multiple epidermal growth factor-li...
MEGF11
621Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU24A0A087WU24_HUMAN
Multiple epidermal growth factor-li...
MEGF11
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WT97A0A087WT97_HUMAN
Multiple epidermal growth factor-li...
MEGF11
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X003A0A087X003_HUMAN
Multiple epidermal growth factor-li...
MEGF11
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47410 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD38994 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05926195S → N1 PublicationCorresponds to variant dbSNP:rs16949528Ensembl.1
Natural variantiVAR_036990242H → R. Corresponds to variant dbSNP:rs333550Ensembl.1
Natural variantiVAR_059262317H → R3 PublicationsCorresponds to variant dbSNP:rs333550Ensembl.1
Natural variantiVAR_059263474L → P. Corresponds to variant dbSNP:rs35309197Ensembl.1
Natural variantiVAR_059264861L → F1 PublicationCorresponds to variant dbSNP:rs3803414Ensembl.1
Natural variantiVAR_059265988I → T. Corresponds to variant dbSNP:rs2303374Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0292461 – 827Missing in isoform 4. 1 PublicationAdd BLAST827
Alternative sequenceiVSP_0292471 – 75Missing in isoform 2. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_02924876 – 101RGLRT…DFCIP → MHTPSIRSITHDAQTSSTGS SAPGTA in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_029249740 – 875CPAAF…WHRRR → KPHLLASQPLRIPCCGLLAT VGIVQTSREGGMQAAPGLVV PDSCPTRTEELCRGSSRPDW IQGIDKPKVLEGQGCKAAQQ HFLGRTVGAYASVRMAPAVT TSVASAPAAQASPGNTVSRD VPQEPLAMGVSSYVSA in isoform 3. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_029250876 – 1044Missing in isoform 3. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_029251904 – 964GACGM…SSYVE → ASTTPWWPVMEHLARPFSQR PRTQLSNKSLDRDTAGWTPY SYVNVLDQCPGGQVPARGLL H in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_029252965 – 1044Missing in isoform 4. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB058677 mRNA Translation: BAB47410.2 Different initiation.
AB300051 mRNA Translation: BAF64841.1
AY358226 mRNA Translation: AAQ88593.1
AC011847 Genomic DNA No translation available.
AC084854 Genomic DNA No translation available.
AC087382 Genomic DNA No translation available.
BC117419 mRNA Translation: AAI17420.1
BC126313 mRNA Translation: AAI26314.1
AL834326 mRNA Translation: CAD38994.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10213.2 [A6BM72-1]

NCBI Reference Sequences

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RefSeqi
NP_115821.2, NM_032445.2 [A6BM72-1]
XP_016878161.1, XM_017022672.1 [A6BM72-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288745; ENSP00000288745; ENSG00000157890 [A6BM72-2]
ENST00000409699; ENSP00000386908; ENSG00000157890 [A6BM72-1]
ENST00000422354; ENSP00000414475; ENSG00000157890 [A6BM72-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84465

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84465

UCSC genome browser

More...
UCSCi
uc002apl.2 human [A6BM72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058677 mRNA Translation: BAB47410.2 Different initiation.
AB300051 mRNA Translation: BAF64841.1
AY358226 mRNA Translation: AAQ88593.1
AC011847 Genomic DNA No translation available.
AC084854 Genomic DNA No translation available.
AC087382 Genomic DNA No translation available.
BC117419 mRNA Translation: AAI17420.1
BC126313 mRNA Translation: AAI26314.1
AL834326 mRNA Translation: CAD38994.1 Different initiation.
CCDSiCCDS10213.2 [A6BM72-1]
RefSeqiNP_115821.2, NM_032445.2 [A6BM72-1]
XP_016878161.1, XM_017022672.1 [A6BM72-1]

3D structure databases

SMRiA6BM72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124098, 2 interactors
IntActiA6BM72, 2 interactors
STRINGi9606.ENSP00000386908

PTM databases

iPTMnetiA6BM72
PhosphoSitePlusiA6BM72

Polymorphism and mutation databases

BioMutaiMEGF11

Proteomic databases

jPOSTiA6BM72
PaxDbiA6BM72
PRIDEiA6BM72
ProteomicsDBi769
770 [A6BM72-2]
771 [A6BM72-3]
772 [A6BM72-4]
TopDownProteomicsiA6BM72-3 [A6BM72-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288745; ENSP00000288745; ENSG00000157890 [A6BM72-2]
ENST00000409699; ENSP00000386908; ENSG00000157890 [A6BM72-1]
ENST00000422354; ENSP00000414475; ENSG00000157890 [A6BM72-1]
GeneIDi84465
KEGGihsa:84465
UCSCiuc002apl.2 human [A6BM72-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84465
DisGeNETi84465

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MEGF11

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0018384
HGNCiHGNC:29635 MEGF11
HPAiHPA017982
MIMi612454 gene
neXtProtiNX_A6BM72
OpenTargetsiENSG00000157890
PharmGKBiPA144596411

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00940000155333
HOGENOMiHOG000294130
InParanoidiA6BM72
OrthoDBi561378at2759
PhylomeDBiA6BM72
TreeFamiTF332598

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MEGF11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84465

Protein Ontology

More...
PROi
PR:A6BM72

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157890 Expressed in 121 organ(s), highest expression level in cerebellum
ExpressionAtlasiA6BM72 baseline and differential
GenevisibleiA6BM72 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR011489 EMI_domain
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF12661 hEGF, 3 hits
PF00053 Laminin_EGF, 8 hits
SMARTiView protein in SMART
SM00181 EGF, 17 hits
SM00180 EGF_Lam, 16 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 17 hits
PS01186 EGF_2, 17 hits
PS50026 EGF_3, 14 hits
PS51041 EMI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEG11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6BM72
Secondary accession number(s): Q17R86
, Q6UXS5, Q8ND91, Q96KG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 24, 2009
Last modified: May 8, 2019
This is version 104 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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