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Entry version 103 (08 May 2019)
Sequence version 3 (24 Nov 2009)
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Protein

Carnosine synthase 1

Gene

CARNS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.09 mM for beta-alanine1 Publication
  2. KM=1.84 mM for gamma-aminobutyrate1 Publication
  3. KM=0.37 mM for L-histidine1 Publication
  4. KM=4.67 mM for L-lysine1 Publication
  5. KM=7.66 mM for L-ornithine1 Publication
  6. KM=24.7 mM for N-methylhistidine1 Publication
  1. Vmax=65.3 nmol/min/mg enzyme toward beta-alanine1 Publication
  2. Vmax=54.7 nmol/min/mg enzyme toward gamma-aminobutyrate1 Publication
  3. Vmax=0.76 nmol/min/mg enzyme toward L-histidine1 Publication
  4. Vmax=0.61 nmol/min/mg enzyme toward L-lysine1 Publication
  5. Vmax=0.28 nmol/min/mg enzyme toward L-ornithine1 Publication
  6. Vmax=0.62 nmol/min/mg enzyme toward N-methylhistidine1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi677Manganese 1By similarity1
Metal bindingi689Manganese 1By similarity1
Metal bindingi689Manganese 2By similarity1
Metal bindingi691Manganese 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi542 – 611ATPPROSITE-ProRule annotationAdd BLAST70

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER66-34422

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.3.2.11 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70921 Histidine catabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carnosine synthase 1 (EC:6.3.2.11)
Alternative name(s):
ATP-grasp domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARNS1
Synonyms:ATPGD1, KIAA1394
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29268 CARNS1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613368 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A5YM72

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57571

Open Targets

More...
OpenTargetsi
ENSG00000172508

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165543288

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CARNS1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003290361 – 827Carnosine synthase 1Add BLAST827

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A5YM72

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A5YM72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A5YM72

PRoteomics IDEntifications database

More...
PRIDEi
A5YM72

ProteomicsDB human proteome resource

More...
ProteomicsDBi
764
765 [A5YM72-2]
766 [A5YM72-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A5YM72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A5YM72

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A5YM72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172508 Expressed in 143 organ(s), highest expression level in inferior vagus X ganglion

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A5YM72 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038569

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121624, 1 interactor

Protein interaction database and analysis system

More...
IntActi
A5YM72, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000389009

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini516 – 720ATP-graspPROSITE-ProRule annotationAdd BLAST205

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH96 Eukaryota
COG0439 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018717

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168640

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A5YM72

KEGG Orthology (KO)

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KOi
K14755

Identification of Orthologs from Complete Genome Data

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OMAi
MAVRICA

Database of Orthologous Groups

More...
OrthoDBi
106215at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A5YM72

TreeFam database of animal gene trees

More...
TreeFami
TF337030

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011761 ATP-grasp
IPR041472 BL00235/CARNS1_N
IPR031046 CARNS1

The PANTHER Classification System

More...
PANTHERi
PTHR10578:SF57 PTHR10578:SF57, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18130 ATPgrasp_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975 ATP_GRASP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A5YM72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLCLSPAWL MKVPAPGQPG EAALLVSKAV SFHPGGLTFL DDFVPPRRAT
60 70 80 90 100
YFLAGLGLGP GRGREAAELA RDLTCPTGAS AELARLLEDR LLTRQLLAQQ
110 120 130 140 150
GGVAVPATLA FTYKPPGLLR GGDASLGLRL VELSGKEGQE TLVKEEVEAF
160 170 180 190 200
LRSEALGDIL QVAVKLSGWR WRGRQAWRLH PRAELGAVVD TVLALLEKLE
210 220 230 240 250
EEESVLVEAV YPPAQLPCSD GPSPGPGLAV RICAVVCRTQ GDRPLLSKVV
260 270 280 290 300
CGVGRGDRPL RHHNSLPRTL EVALAQCGLG EEAQVAAVRQ RVKAAAEAAL
310 320 330 340 350
AAVLALEAGL SAEQRGGRRA HTDFLGVDFA LTAAGGVLTP VALELNGGLC
360 370 380 390 400
LEACGALEGL WAAPRLGPAA DEAVAAPLVE TMLRRSARCL MEGKQLLVVG
410 420 430 440 450
AGGVSKKFVW EAARDYGLQL HLVESDPNHF ASQLVQTFIH FDMTEHRRDE
460 470 480 490 500
ENARLLAELV RARGLKLDGC FSYWDDCLVL TALLCQELGL PCSSPAAMRL
510 520 530 540 550
AKQKSLTQLH LLHHHGPPWP APSLHAVPCC PLESEADVER AVHQVPLPGV
560 570 580 590 600
MKLEFGAGAV GVRLVEDAPQ CHEHFSRITR DLQGEADHPG IGLGWGNAML
610 620 630 640 650
LMEFVEGTEH DVDLVLFGGR LLAAFVSDNG PTRLPGFTET AACMPTGLAP
660 670 680 690 700
EQEAQMVQAA FRCCLGCGLL DGVFNVELKL TGAGPRLIEI NPRMGGFYLR
710 720 730 740 750
DWILELYGVD LLLAAVMVAC GLRPALPTRP RARGHLVGVM CLVSQHLQAL
760 770 780 790 800
SSTASRETLQ ALHDRGLLRL NLLEEALVPG EYEEPYCSVA CAGPSPTEAR
810 820
LRLLGLCQGL GIDGPSYPVA HFLSHFK
Length:827
Mass (Da):88,484
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18AEFC6A5299B8EF
GO
Isoform 2 (identifier: A5YM72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-442: Missing.

Show »
Length:385
Mass (Da):41,773
Checksum:i3FC2B6761C4B9192
GO
Isoform 3 (identifier: A5YM72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCPLAHPAQD...EGGVQSPGNM

Note: No experimental confirmation available.
Show »
Length:966
Mass (Da):103,002
Checksum:i24A529E929356016
GO
Isoform 4 (identifier: A5YM72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSLDPSGPE...EGGVQSPGNM
     272-297: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:924
Mass (Da):98,699
Checksum:i188095CB41F4F85C
GO
Isoform 5 (identifier: A5YM72-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSLDPSGPE...EGGVQSPGNM

Note: No experimental confirmation available.
Show »
Length:950
Mass (Da):101,320
Checksum:iF9DE9392066303D8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABQ59056 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA92632 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23A → T in ABQ59056 (Ref. 1) Curated1
Sequence conflicti576S → P in BAF82627 (PubMed:14702039).Curated1
Sequence conflicti800R → H in BAF82627 (PubMed:14702039).Curated1
Isoform 4 (identifier: A5YM72-4)
Sequence conflicti2L → F in BAG57387 (PubMed:14702039).Curated1
Sequence conflicti395A → V in BAG57387 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04262514P → T. Corresponds to variant dbSNP:rs868167Ensembl.1
Natural variantiVAR_060320498M → L1 PublicationCorresponds to variant dbSNP:rs17853668Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0329251 – 442Missing in isoform 2. 2 PublicationsAdd BLAST442
Alternative sequenceiVSP_0329261M → MCPLAHPAQDLPLLPSQLSL DPSGPEWDCPLGSKDLEEEG PWGGGSGLPPTGCFPGSWRQ DVGLDCKGSPEGAEARAWTV YYYSLLQSCLQQAGLPETQD RGQVPRTGCPGAEVTLCVLG SPSTFLPVLLEGGVQSPGNM in isoform 3. 1 Publication1
Alternative sequenceiVSP_0537351M → MLSLDPSGPEWDCPLGSKDL EEEGPWGGGSGLPPTGCFPG SWRQDVGLDCKGSPEGAEAR AWTVYYYSLLQSCLQQAGLP ETQDRGQVPRTGCPGAEVTL CVLGSPSTFLPVLLEGGVQS PGNM in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_053736272 – 297Missing in isoform 4. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF560746 mRNA Translation: ABQ59056.1 Different initiation.
AB037815 mRNA Translation: BAA92632.1 Different initiation.
AK289938 mRNA Translation: BAF82627.1
AK294035 mRNA Translation: BAG57387.1
AP003419 Genomic DNA No translation available.
BC036557 mRNA Translation: AAH36557.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44658.1 [A5YM72-1]
CCDS53667.1 [A5YM72-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001159694.1, NM_001166222.1 [A5YM72-5]
NP_065862.1, NM_020811.1 [A5YM72-1]
XP_011543491.1, XM_011545189.2
XP_016873543.1, XM_017018054.1 [A5YM72-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307823; ENSP00000308268; ENSG00000172508 [A5YM72-1]
ENST00000445895; ENSP00000389009; ENSG00000172508 [A5YM72-5]
ENST00000531040; ENSP00000431670; ENSG00000172508 [A5YM72-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57571

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57571

UCSC genome browser

More...
UCSCi
uc009yrp.3 human [A5YM72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF560746 mRNA Translation: ABQ59056.1 Different initiation.
AB037815 mRNA Translation: BAA92632.1 Different initiation.
AK289938 mRNA Translation: BAF82627.1
AK294035 mRNA Translation: BAG57387.1
AP003419 Genomic DNA No translation available.
BC036557 mRNA Translation: AAH36557.1
CCDSiCCDS44658.1 [A5YM72-1]
CCDS53667.1 [A5YM72-5]
RefSeqiNP_001159694.1, NM_001166222.1 [A5YM72-5]
NP_065862.1, NM_020811.1 [A5YM72-1]
XP_011543491.1, XM_011545189.2
XP_016873543.1, XM_017018054.1 [A5YM72-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121624, 1 interactor
IntActiA5YM72, 1 interactor
STRINGi9606.ENSP00000389009

PTM databases

iPTMnetiA5YM72
PhosphoSitePlusiA5YM72
SwissPalmiA5YM72

Polymorphism and mutation databases

BioMutaiCARNS1

Proteomic databases

jPOSTiA5YM72
MaxQBiA5YM72
PaxDbiA5YM72
PRIDEiA5YM72
ProteomicsDBi764
765 [A5YM72-2]
766 [A5YM72-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307823; ENSP00000308268; ENSG00000172508 [A5YM72-1]
ENST00000445895; ENSP00000389009; ENSG00000172508 [A5YM72-5]
ENST00000531040; ENSP00000431670; ENSG00000172508 [A5YM72-4]
GeneIDi57571
KEGGihsa:57571
UCSCiuc009yrp.3 human [A5YM72-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57571
DisGeNETi57571

GeneCards: human genes, protein and diseases

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GeneCardsi
CARNS1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0201593
HGNCiHGNC:29268 CARNS1
HPAiHPA038569
MIMi613368 gene
neXtProtiNX_A5YM72
OpenTargetsiENSG00000172508
PharmGKBiPA165543288

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IH96 Eukaryota
COG0439 LUCA
GeneTreeiENSGT00390000018717
HOGENOMiHOG000168640
InParanoidiA5YM72
KOiK14755
OMAiMAVRICA
OrthoDBi106215at2759
PhylomeDBiA5YM72
TreeFamiTF337030

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-34422
BRENDAi6.3.2.11 2681
ReactomeiR-HSA-70921 Histidine catabolism

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57571

Protein Ontology

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PROi
PR:A5YM72

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000172508 Expressed in 143 organ(s), highest expression level in inferior vagus X ganglion
GenevisibleiA5YM72 HS

Family and domain databases

InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR041472 BL00235/CARNS1_N
IPR031046 CARNS1
PANTHERiPTHR10578:SF57 PTHR10578:SF57, 1 hit
PfamiView protein in Pfam
PF18130 ATPgrasp_N, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRNS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5YM72
Secondary accession number(s): A8K1M3
, B4DFC6, E9PK38, F5H427, Q8N467, Q9P2F3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 24, 2009
Last modified: May 8, 2019
This is version 103 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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