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Protein

Rho guanine nucleotide exchange factor 35

Gene

ARHGEF35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 35
Alternative name(s):
Rho guanine nucleotide exchange factor 5-like protein
Gene namesi
Name:ARHGEF35
Synonyms:ARHGEF5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000213214.4
HGNCiHGNC:33846 ARHGEF35
neXtProtiNX_A5YM69

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213214
PharmGKBiPA165617645

Polymorphism and mutation databases

BioMutaiARHGEF35

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003484621 – 484Rho guanine nucleotide exchange factor 35Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA5YM69
MaxQBiA5YM69
PaxDbiA5YM69
PRIDEiA5YM69
ProteomicsDBi763

PTM databases

iPTMnetiA5YM69
PhosphoSitePlusiA5YM69

Expressioni

Gene expression databases

BgeeiENSG00000213214 Expressed in 85 organ(s), highest expression level in thyroid gland

Organism-specific databases

HPAiHPA044188
HPA045619
HPA045699

Interactioni

Protein-protein interaction databases

BioGridi138643, 6 interactors
STRINGi9606.ENSP00000367355

Structurei

3D structure databases

ProteinModelPortaliA5YM69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 401Glu-richAdd BLAST256

Phylogenomic databases

eggNOGiKOG3523 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00910000145825
HOGENOMiHOG000206598
InParanoidiA5YM69
OMAiCDTPEDW
OrthoDBiEOG091G00P4
PhylomeDBiA5YM69

Family and domain databases

InterProiView protein in InterPro
IPR029212 ARHGEF5/35_N
PfamiView protein in Pfam
PF15441 ARHGEF5_35, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A5YM69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEEAQHGA SPPISAIEEF SIIPEAPMRS SQVSALGLEA QEDEDPSYKW
60 70 80 90 100
REEHRLSATQ QSELRDVCDY AIETMPSFPK EGSADVEPNQ ESLVAEACDT
110 120 130 140 150
PEHWEAVPQS LAGRQARTLA PPELWACPIQ SEHLDMAPFS SDLGSEEEEV
160 170 180 190 200
EFWPGLTSLT LGSGQAEEEE ETSSDNSGQT RYYSPCEEHP AETNQNEGAE
210 220 230 240 250
SGTIRQGEEL PSEELQESQG LLHPQEVQVL EEQGQQEAGF RGEGTLREDV
260 270 280 290 300
CADGLLGEEQ MIEQVNDEKG EQKQKQEQVQ DVMLGRQGER MGLTGEPEGL
310 320 330 340 350
NDGEWEQEDM ERKAQGQGGP EQGEERKREL QVPEENRADS QDEKSQTFLG
360 370 380 390 400
KSEEVTGKQE DHGIKEKGVP VSGQEAKEPE SWDGGRLGAV GRARSREEEN
410 420 430 440 450
EHHGPSMPAL IAPEDSPHCD LFPGASYLVT QIPGTQTESR AEELSPAALS
460 470 480
PLLEPIRCSH QPISLLGSFL TEESPDKEKL LSVL
Length:484
Mass (Da):53,287
Last modified:July 10, 2007 - v1
Checksum:iB495D13224E9E52C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y614A0A2R8Y614_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF35
484Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8H → R in BAC86243 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF560743 mRNA Translation: ABQ59053.1
AK125680 mRNA Translation: BAC86243.1
BC136868 mRNA Translation: AAI36869.1
BC136878 mRNA Translation: AAI36879.1
CCDSiCCDS34770.1
RefSeqiNP_001003702.2, NM_001003702.2
XP_016885946.1, XM_017030457.1
UniGeneiHs.534621

Genome annotation databases

EnsembliENST00000378115; ENSP00000367355; ENSG00000213214
GeneIDi445328
KEGGihsa:445328
UCSCiuc003wdz.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF560743 mRNA Translation: ABQ59053.1
AK125680 mRNA Translation: BAC86243.1
BC136868 mRNA Translation: AAI36869.1
BC136878 mRNA Translation: AAI36879.1
CCDSiCCDS34770.1
RefSeqiNP_001003702.2, NM_001003702.2
XP_016885946.1, XM_017030457.1
UniGeneiHs.534621

3D structure databases

ProteinModelPortaliA5YM69
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138643, 6 interactors
STRINGi9606.ENSP00000367355

PTM databases

iPTMnetiA5YM69
PhosphoSitePlusiA5YM69

Polymorphism and mutation databases

BioMutaiARHGEF35

Proteomic databases

EPDiA5YM69
MaxQBiA5YM69
PaxDbiA5YM69
PRIDEiA5YM69
ProteomicsDBi763

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378115; ENSP00000367355; ENSG00000213214
GeneIDi445328
KEGGihsa:445328
UCSCiuc003wdz.3 human

Organism-specific databases

CTDi445328
EuPathDBiHostDB:ENSG00000213214.4
GeneCardsiARHGEF35
H-InvDBiHIX0007176
HIX0025383
HGNCiHGNC:33846 ARHGEF35
HPAiHPA044188
HPA045619
HPA045699
neXtProtiNX_A5YM69
OpenTargetsiENSG00000213214
PharmGKBiPA165617645
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3523 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00910000145825
HOGENOMiHOG000206598
InParanoidiA5YM69
OMAiCDTPEDW
OrthoDBiEOG091G00P4
PhylomeDBiA5YM69

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

GenomeRNAii445328
PROiPR:A5YM69

Gene expression databases

BgeeiENSG00000213214 Expressed in 85 organ(s), highest expression level in thyroid gland

Family and domain databases

InterProiView protein in InterPro
IPR029212 ARHGEF5/35_N
PfamiView protein in Pfam
PF15441 ARHGEF5_35, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARG35_HUMAN
AccessioniPrimary (citable) accession number: A5YM69
Secondary accession number(s): Q6ZUI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 10, 2007
Last modified: September 12, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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