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Protein

CCR4-NOT transcription complex subunit 1

Gene

CNOT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.7 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 1
Alternative name(s):
CCR4-associated factor 1
Negative regulator of transcription subunit 1 homolog
Short name:
NOT1H
Short name:
hNOT1
Gene namesi
Name:CNOT1
Synonyms:CDC39, KIAA1007, NOT1
ORF Names:AD-005
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000125107.16
HGNCiHGNC:7877 CNOT1
MIMi604917 gene
neXtProtiNX_A5YKK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1208K → E: Impairs interaction with CNOT7; when associated with Y-1212 and E-1218. 1 Publication1
Mutagenesisi1209P → Y: Abolishes interaction with CNOT7; when associated with Y-1257. 1
Mutagenesisi1212H → Y: Impairs interaction with CNOT7; when associated with E-1208 and E-1218. 1 Publication1
Mutagenesisi1218K → E: Impairs interaction with CNOT7; when associated with E-1208 and Y-1212. 1 Publication1
Mutagenesisi1251V → R: Abolishes interaction with CNOT7. 1
Mutagenesisi1257P → Y: Abolishes interaction with CNOT7; when associated with Y-1209. 1

Organism-specific databases

DisGeNETi23019
OpenTargetsiENSG00000125107
PharmGKBiPA26672

Polymorphism and mutation databases

BioMutaiCNOT1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003155411 – 2376CCR4-NOT transcription complex subunit 1Add BLAST2376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318PhosphoserineCombined sources1
Modified residuei1061PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA5YKK6
MaxQBiA5YKK6
PaxDbiA5YKK6
PRIDEiA5YKK6
ProteomicsDBi759
760 [A5YKK6-2]
761 [A5YKK6-3]
762 [A5YKK6-4]

PTM databases

CarbonylDBiA5YKK6
iPTMnetiA5YKK6
PhosphoSitePlusiA5YKK6
SwissPalmiA5YKK6

Expressioni

Tissue specificityi

Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon.1 Publication

Developmental stagei

Expressed in embryonic stem (ES) cells.1 Publication

Gene expression databases

BgeeiENSG00000125107 Expressed in 232 organ(s), highest expression level in testis
ExpressionAtlasiA5YKK6 baseline and differential
GenevisibleiA5YKK6 HS

Organism-specific databases

HPAiHPA046577
HPA049664

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36. Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct.9 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116660, 114 interactors
CORUMiA5YKK6
DIPiDIP-44954N
ELMiA5YKK6
IntActiA5YKK6, 81 interactors
MINTiA5YKK6
STRINGi9606.ENSP00000320949

Structurei

Secondary structure

12376
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliA5YKK6
SMRiA5YKK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni800 – 1015Interaction with ZFP36Add BLAST216
Regioni1090 – 1605Interaction with CNOT6, CNOT6L, CNOT7 and CNOT81 PublicationAdd BLAST516

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi153 – 157LXXLL5
Motifi181 – 185LXXLL5
Motifi223 – 227LXXLL5
Motifi570 – 574LXXLL5
Motifi1639 – 1643LXXLL5
Motifi1942 – 1946LXXLL5
Motifi2096 – 2100LXXLL5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1333 – 1350Thr-richAdd BLAST18

Domaini

Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.1 Publication

Sequence similaritiesi

Belongs to the CNOT1 family.Curated

Phylogenomic databases

eggNOGiKOG1831 Eukaryota
COG5103 LUCA
GeneTreeiENSGT00390000014869
HOVERGENiHBG060834
InParanoidiA5YKK6
KOiK12604
OMAiTYPRLIN
OrthoDBiEOG091G0050
PhylomeDBiA5YKK6
TreeFamiTF105630

Family and domain databases

Gene3Di1.25.40.180, 1 hit
1.25.40.840, 1 hit
InterProiView protein in InterPro
IPR007196 CCR4-Not_Not1_C
IPR024557 CCR4-Not_Not1su_DUF3819
IPR032191 CNOT1_CAF1_bind
IPR032194 CNOT1_HEAT
IPR032193 CNOT1_TTP_bind
IPR038535 CNOT1_TTP_bind_sf
IPR016021 MIF4-like_sf
PfamiView protein in Pfam
PF16415 CNOT1_CAF1_bind, 1 hit
PF16418 CNOT1_HEAT, 1 hit
PF16417 CNOT1_TTP_bind, 1 hit
PF12842 DUF3819, 1 hit
PF04054 Not1, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A5YKK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC
60 70 80 90 100
LFSHVDFSGD GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH
110 120 130 140 150
YQKSLKPAPH LFAQLSKVLK LSKVQEVIFG LALLNSSSSD LRGFAAQFIK
160 170 180 190 200
QKLPDLLRSY IDADVSGNQE GGFQDIAIEV LHLLLSHLLF GQKGAFGVGQ
210 220 230 240 250
EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL PDSGGVAKTM
260 270 280 290 300
MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART
310 320 330 340 350
HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP
360 370 380 390 400
SLNFKEVTYE LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK
410 420 430 440 450
HAEGQLSFIQ HSLINPEIFC FADYPCHTVA TDILKAPPED DNREIATWKS
460 470 480 490 500
LDLIESLLRL AEVGQYEQVK QLFSFPIKHC PDMLVLALLQ INTSWHTLRH
510 520 530 540 550
ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH AMAEWYMRGE
560 570 580 590 600
QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW
610 620 630 640 650
LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT
660 670 680 690 700
MLACLQACAG SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA
710 720 730 740 750
SSLDAISPVQ IDPLAGMTSL SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP
760 770 780 790 800
AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG LGTGSLTGIG TGALGLPAVN
810 820 830 840 850
NDPFVQRKLG TSGLNQPTFQ QSKMKPSDLS QVWPEANQHF SKEIDDEANS
860 870 880 890 900
YFQRIYNHPP HPTMSVDEVL EMLQRFKDST IKREREVFNC MLRNLFEEYR
910 920 930 940 950
FFPQYPDKEL HITACLFGGI IEKGLVTYMA LGLALRYVLE ALRKPFGSKM
960 970 980 990 1000
YYFGIAALDR FKNRLKDYPQ YCQHLASISH FMQFPHHLQE YIEYGQQSRD
1010 1020 1030 1040 1050
PPVKMQGSIT TPGSIALAQA QAQAQVPAKA PLAGQVSTMV TTSTTTTVAK
1060 1070 1080 1090 1100
TVTVTRPTGV SFKKDVPPSI NTTNIDTLLV ATDQTERIVE PPENIQEKIA
1110 1120 1130 1140 1150
FIFNNLSQSN MTQKVEELKE TVKEEFMPWV SQYLVMKRVS IEPNFHSLYS
1160 1170 1180 1190 1200
NFLDTLKNPE FNKMVLNETY RNIKVLLTSD KAAANFSDRS LLKNLGHWLG
1210 1220 1230 1240 1250
MITLAKNKPI LHTDLDVKSL LLEAYVKGQQ ELLYVVPFVA KVLESSIRSV
1260 1270 1280 1290 1300
VFRPPNPWTM AIMNVLAELH QEHDLKLNLK FEIEVLCKNL ALDINELKPG
1310 1320 1330 1340 1350
NLLKDKDRLK NLDEQLSAPK KDVKQPEELP PITTTTTSTT PATNTTCTAT
1360 1370 1380 1390 1400
VPPQPQYSYH DINVYSLAGL APHITLNPTI PLFQAHPQLK QCVRQAIERA
1410 1420 1430 1440 1450
VQELVHPVVD RSIKIAMTTC EQIVRKDFAL DSEESRMRIA AHHMMRNLTA
1460 1470 1480 1490 1500
GMAMITCREP LLMSISTNLK NSFASALRTA SPQQREMMDQ AAAQLAQDNC
1510 1520 1530 1540 1550
ELACCFIQKT AVEKAGPEMD KRLATEFELR KHARQEGRRY CDPVVLTYQA
1560 1570 1580 1590 1600
ERMPEQIRLK VGGVDPKQLA VYEEFARNVP GFLPTNDLSQ PTGFLAQPMK
1610 1620 1630 1640 1650
QAWATDDVAQ IYDKCITELE QHLHAIPPTL AMNPQAQALR SLLEVVVLSR
1660 1670 1680 1690 1700
NSRDAIAALG LLQKAVEGLL DATSGADADL LLRYRECHLL VLKALQDGRA
1710 1720 1730 1740 1750
YGSPWCNKQI TRCLIECRDE YKYNVEAVEL LIRNHLVNMQ QYDLHLAQSM
1760 1770 1780 1790 1800
ENGLNYMAVA FAMQLVKILL VDERSVAHVT EADLFHTIET LMRINAHSRG
1810 1820 1830 1840 1850
NAPEGLPQLM EVVRSNYEAM IDRAHGGPNF MMHSGISQAS EYDDPPGLRE
1860 1870 1880 1890 1900
KAEYLLREWV NLYHSAAAGR DSTKAFSAFV GQMHQQGILK TDDLITRFFR
1910 1920 1930 1940 1950
LCTEMCVEIS YRAQAEQQHN PAANPTMIRA KCYHNLDAFV RLIALLVKHS
1960 1970 1980 1990 2000
GEATNTVTKI NLLNKVLGIV VGVLLQDHDV RQSEFQQLPY HRIFIMLLLE
2010 2020 2030 2040 2050
LNAPEHVLET INFQTLTAFC NTFHILRPTK APGFVYAWLE LISHRIFIAR
2060 2070 2080 2090 2100
MLAHTPQQKG WPMYAQLLID LFKYLAPFLR NVELTKPMQI LYKGTLRVLL
2110 2120 2130 2140 2150
VLLHDFPEFL CDYHYGFCDV IPPNCIQLRN LILSAFPRNM RLPDPFTPNL
2160 2170 2180 2190 2200
KVDMLSEINI APRILTNFTG VMPPQFKKDL DSYLKTRSPV TFLSDLRSNL
2210 2220 2230 2240 2250
QVSNEPGNRY NLQLINALVL YVGTQAIAHI HNKGSTPSMS TITHSAHMDI
2260 2270 2280 2290 2300
FQNLAVDLDT EGRYLFLNAI ANQLRYPNSH THYFSCTMLY LFAEANTEAI
2310 2320 2330 2340 2350
QEQITRVLLE RLIVNRPHPW GLLITFIELI KNPAFKFWNH EFVHCAPEIE
2360 2370
KLFQSVAQCC MGQKQAQQVM EGTGAS
Length:2,376
Mass (Da):266,939
Last modified:January 15, 2008 - v2
Checksum:i937A0899537BA615
GO
Isoform 2 (identifier: A5YKK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     822-827: SKMKPS → T

Show »
Length:2,371
Mass (Da):266,381
Checksum:i23D129C7F9CE775B
GO
Isoform 3 (identifier: A5YKK6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     822-827: SKMKPS → T
     2152-2155: VDML → SLTL
     2156-2376: Missing.

Show »
Length:2,150
Mass (Da):241,260
Checksum:iBBB731593591523C
GO
Isoform 4 (identifier: A5YKK6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1479-1551: TASPQQREMM...DPVVLTYQAE → VSWLFPWYRY...FFLLYSQHDV
     1552-2376: Missing.

Show »
Length:1,551
Mass (Da):173,792
Checksum:i00329322012ABAD2
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR89H3BR89_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
193Annotation score:
H3BMH0H3BMH0_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
277Annotation score:
H3BTH2H3BTH2_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
68Annotation score:
H3BMZ2H3BMZ2_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
439Annotation score:
H3BVC9H3BVC9_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
241Annotation score:
H3BNB1H3BNB1_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
185Annotation score:
H3BT18H3BT18_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
62Annotation score:
H3BPF1H3BPF1_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
25Annotation score:
H3BU44H3BU44_HUMAN
CCR4-NOT transcription complex subu...
CNOT1
96Annotation score:

Sequence cautioni

The sequence AAF14861 differs from that shown. Reason: Frameshift at positions 1969 and 2273.Curated
The sequence CAH18093 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18D → G in CAD97851 (PubMed:17974005).Curated1
Sequence conflicti323D → G in CAD97851 (PubMed:17974005).Curated1
Sequence conflicti922E → G in ABQ66268 (PubMed:17974005).Curated1
Sequence conflicti1063K → R in CAH18093 (PubMed:17974005).Curated1
Sequence conflicti1417M → V in CAD97851 (PubMed:17974005).Curated1
Sequence conflicti1799R → G in CAD97851 (PubMed:17974005).Curated1
Sequence conflicti1936L → P in CAH18093 (PubMed:17974005).Curated1
Sequence conflicti2198 – 2200SNL → RTV in AAF14861 (PubMed:10931946).Curated3
Sequence conflicti2358Q → R in ABQ66268 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038254603D → A1 PublicationCorresponds to variant dbSNP:rs17854028Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030559822 – 827SKMKPS → T in isoform 2 and isoform 3. 2 Publications6
Alternative sequenceiVSP_0305601479 – 1551TASPQ…TYQAE → VSWLFPWYRYKTYYCLSVII FFFVYIWHWALPLILNNHHI CLMSSIILDCNSVRQSIMSV CFFFFLLYSQHDV in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0305611552 – 2376Missing in isoform 4. 1 PublicationAdd BLAST825
Alternative sequenceiVSP_0305622152 – 2155VDML → SLTL in isoform 3. 1 Publication4
Alternative sequenceiVSP_0305632156 – 2376Missing in isoform 3. 1 PublicationAdd BLAST221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117492 mRNA Translation: CAB55960.1
BX537840 mRNA Translation: CAD97851.1
CR749237 mRNA Translation: CAH18093.1 Different initiation.
EF553522 mRNA Translation: ABQ66268.1
AC009118 Genomic DNA No translation available.
AC010287 Genomic DNA No translation available.
BC000779 mRNA Translation: AAH00779.2
BC024317 mRNA Translation: AAH24317.1
BC040523 mRNA Translation: AAH40523.1
AB023224 mRNA Translation: BAA76851.2
AF110778 mRNA Translation: AAF14861.1 Frameshift.
CCDSiCCDS10799.1 [A5YKK6-1]
CCDS45501.1 [A5YKK6-4]
CCDS58468.1 [A5YKK6-2]
PIRiT17270
RefSeqiNP_001252541.1, NM_001265612.1 [A5YKK6-2]
NP_057368.3, NM_016284.4 [A5YKK6-1]
NP_996882.1, NM_206999.2 [A5YKK6-4]
UniGeneiHs.460923
Hs.731691

Genome annotation databases

EnsembliENST00000317147; ENSP00000320949; ENSG00000125107 [A5YKK6-1]
ENST00000441024; ENSP00000413113; ENSG00000125107 [A5YKK6-4]
ENST00000567188; ENSP00000456649; ENSG00000125107 [A5YKK6-3]
ENST00000569240; ENSP00000455635; ENSG00000125107 [A5YKK6-2]
GeneIDi23019
KEGGihsa:23019
UCSCiuc002enu.6 human [A5YKK6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117492 mRNA Translation: CAB55960.1
BX537840 mRNA Translation: CAD97851.1
CR749237 mRNA Translation: CAH18093.1 Different initiation.
EF553522 mRNA Translation: ABQ66268.1
AC009118 Genomic DNA No translation available.
AC010287 Genomic DNA No translation available.
BC000779 mRNA Translation: AAH00779.2
BC024317 mRNA Translation: AAH24317.1
BC040523 mRNA Translation: AAH40523.1
AB023224 mRNA Translation: BAA76851.2
AF110778 mRNA Translation: AAF14861.1 Frameshift.
CCDSiCCDS10799.1 [A5YKK6-1]
CCDS45501.1 [A5YKK6-4]
CCDS58468.1 [A5YKK6-2]
PIRiT17270
RefSeqiNP_001252541.1, NM_001265612.1 [A5YKK6-2]
NP_057368.3, NM_016284.4 [A5YKK6-1]
NP_996882.1, NM_206999.2 [A5YKK6-4]
UniGeneiHs.460923
Hs.731691

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20A1565-2371[»]
4CQOX-ray2.80A/C1833-2361[»]
4CRUX-ray1.65A1356-1607[»]
4CRVX-ray2.05A1356-1607[»]
4CRWX-ray1.75A1093-1317[»]
4CT4X-ray2.30A/C1063-1314[»]
4CT6X-ray2.10A1352-1594[»]
4CT7X-ray1.90A1352-1594[»]
4GMJX-ray2.70A/C/E1093-1317[»]
4GMLX-ray2.90A/B/C/D/E/F1093-1317[»]
4J8SX-ray1.55A800-1004[»]
5ANRX-ray2.10A1063-1314[»]
5FU6X-ray2.90A/D1833-2361[»]
5FU7X-ray3.10A/E1833-2361[»]
5ONAX-ray2.70A/D1351-1588[»]
ProteinModelPortaliA5YKK6
SMRiA5YKK6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116660, 114 interactors
CORUMiA5YKK6
DIPiDIP-44954N
ELMiA5YKK6
IntActiA5YKK6, 81 interactors
MINTiA5YKK6
STRINGi9606.ENSP00000320949

PTM databases

CarbonylDBiA5YKK6
iPTMnetiA5YKK6
PhosphoSitePlusiA5YKK6
SwissPalmiA5YKK6

Polymorphism and mutation databases

BioMutaiCNOT1

Proteomic databases

EPDiA5YKK6
MaxQBiA5YKK6
PaxDbiA5YKK6
PRIDEiA5YKK6
ProteomicsDBi759
760 [A5YKK6-2]
761 [A5YKK6-3]
762 [A5YKK6-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317147; ENSP00000320949; ENSG00000125107 [A5YKK6-1]
ENST00000441024; ENSP00000413113; ENSG00000125107 [A5YKK6-4]
ENST00000567188; ENSP00000456649; ENSG00000125107 [A5YKK6-3]
ENST00000569240; ENSP00000455635; ENSG00000125107 [A5YKK6-2]
GeneIDi23019
KEGGihsa:23019
UCSCiuc002enu.6 human [A5YKK6-1]

Organism-specific databases

CTDi23019
DisGeNETi23019
EuPathDBiHostDB:ENSG00000125107.16
GeneCardsiCNOT1
H-InvDBiHIX0013093
HGNCiHGNC:7877 CNOT1
HPAiHPA046577
HPA049664
MIMi604917 gene
neXtProtiNX_A5YKK6
OpenTargetsiENSG00000125107
PharmGKBiPA26672
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1831 Eukaryota
COG5103 LUCA
GeneTreeiENSGT00390000014869
HOVERGENiHBG060834
InParanoidiA5YKK6
KOiK12604
OMAiTYPRLIN
OrthoDBiEOG091G0050
PhylomeDBiA5YKK6
TreeFamiTF105630

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Miscellaneous databases

ChiTaRSiCNOT1 human
GeneWikiiCNOT1
GenomeRNAii23019
PROiPR:A5YKK6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125107 Expressed in 232 organ(s), highest expression level in testis
ExpressionAtlasiA5YKK6 baseline and differential
GenevisibleiA5YKK6 HS

Family and domain databases

Gene3Di1.25.40.180, 1 hit
1.25.40.840, 1 hit
InterProiView protein in InterPro
IPR007196 CCR4-Not_Not1_C
IPR024557 CCR4-Not_Not1su_DUF3819
IPR032191 CNOT1_CAF1_bind
IPR032194 CNOT1_HEAT
IPR032193 CNOT1_TTP_bind
IPR038535 CNOT1_TTP_bind_sf
IPR016021 MIF4-like_sf
PfamiView protein in Pfam
PF16415 CNOT1_CAF1_bind, 1 hit
PF16418 CNOT1_HEAT, 1 hit
PF16417 CNOT1_TTP_bind, 1 hit
PF12842 DUF3819, 1 hit
PF04054 Not1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNOT1_HUMAN
AccessioniPrimary (citable) accession number: A5YKK6
Secondary accession number(s): Q68DX7
, Q7Z3K2, Q8IWB8, Q8TB53, Q9BVZ6, Q9UFR8, Q9UI27, Q9Y2L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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