Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Tumor necrosis factor

Gene

TNF-alpha

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factorImported
Gene namesi
Name:TNF-alphaImported
OrganismiOvis aries (Sheep)Imported
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 55HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

Expressioni

Gene expression databases

ExpressionAtlasiA5YBV0 baseline

Interactioni

Subunit structurei

Homotrimer.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA5YBV0
SMRiA5YBV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 234TNF_2InterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012516
KOiK03156
OMAiPWYEPIY
OrthoDBiEOG091G0HIG

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002959 TNF_alpha
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF23 PTHR11471:SF23, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01235 TNFALPHA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5YBV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKSMIRDV ELAEEVLSNK AGGPQGSRSC WCLSLFSFLL VAGATTLFCL
60 70 80 90 100
LHFGVIGPQR EEQSPAGPSF NRPLVQTLRS SSQASNNKPV AHVVANISAP
110 120 130 140 150
GQLRWGDSYA NALMANGVEL KDNQLVVPTD GLYLIYSQVL FRGHGCPSTP
160 170 180 190 200
LFLTHTISRI AVSYQTKVNI LSAIKSPCHR ETLEGAEAKP WYEPIYQGGV
210 220 230
FQLEKGDRLS AEINLPEYLD YAESGQVYFG IIAL
Length:234
Mass (Da):25,536
Last modified:July 10, 2007 - v1
Checksum:i4BCF8CCAB7956B88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF446377 Genomic DNA Translation: ABR01166.1
RefSeqiNP_001020031.1, NM_001024860.1
UniGeneiOar.455

Genome annotation databases

GeneIDi443540
KEGGioas:443540

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF446377 Genomic DNA Translation: ABR01166.1
RefSeqiNP_001020031.1, NM_001024860.1
UniGeneiOar.455

3D structure databases

ProteinModelPortaliA5YBV0
SMRiA5YBV0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443540
KEGGioas:443540

Organism-specific databases

CTDi7124

Phylogenomic databases

HOVERGENiHBG012516
KOiK03156
OMAiPWYEPIY
OrthoDBiEOG091G0HIG

Gene expression databases

ExpressionAtlasiA5YBV0 baseline

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002959 TNF_alpha
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF23 PTHR11471:SF23, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01235 TNFALPHA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA5YBV0_SHEEP
AccessioniPrimary (citable) accession number: A5YBV0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 12, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again