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Entry version 71 (19 Jan 2022)
Sequence version 1 (10 Jul 2007)
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Protein
Submitted name:

MDR-like ABC transporter

Gene

mdr

Organism
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi397 – 404ATPPROSITE-ProRule annotation8
Nucleotide bindingi1058 – 1065ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.201.25, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MDR-like ABC transporterImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdrImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4058 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthinaeCatharanthus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 46HelicalSequence analysisAdd BLAST26
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei160 – 179HelicalSequence analysisAdd BLAST20
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei262 – 286HelicalSequence analysisAdd BLAST25
Transmembranei701 – 722HelicalSequence analysisAdd BLAST22
Transmembranei742 – 760HelicalSequence analysisAdd BLAST19
Transmembranei816 – 836HelicalSequence analysisAdd BLAST21
Transmembranei843 – 862HelicalSequence analysisAdd BLAST20
Transmembranei935 – 953HelicalSequence analysisAdd BLAST19
Transmembranei965 – 983HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A5X7X7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 327ABC transmembrane type-1InterPro annotationAdd BLAST289
Domaini362 – 598ABC transporterInterPro annotationAdd BLAST237
Domaini702 – 988ABC transmembrane type-1InterPro annotationAdd BLAST287
Domaini1023 – 1260ABC transporterInterPro annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni629 – 648DisorderedSequence analysisAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 1 hit
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like_ATP-bd
IPR017871, ABC_transporter-like_CS
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5X7X7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKSEDGAPN SPSSSKDNEK VPFLKLFSFA DGMDIALMII GTLGGIGNGL
60 70 80 90 100
AQPIMTVILG QLINTFGTNI YDKSEILHQV GQVSLKYVYL AIGAGMASFL
110 120 130 140 150
QMSCWMVTGE RQATRIRGLY LKTILRQDIG FFDTETSTGE VIGRMSGDTI
160 170 180 190 200
LIQEAMGEKV GKFIQFSSTF IGGFLIAFIK GWLLALVLTA CLPLLVATGA
210 220 230 240 250
VMSLFMSKMA SQGQVAYAEA GNVLEQTVGG IRTVASFTGE KLAIQKYNNK
260 270 280 290 300
LKVAYRTTVK QGFASGAGFG TLLLVVFCIY GLAIYYGSRL IIEKGYNGGR
310 320 330 340 350
VINVMMAIMM GGMSLGQTSP SLSAFAAGQA AAYKMFETIK RKPQIDAYDT
360 370 380 390 400
SGIVLEDIKG EIELKDVYFR YPARPEVQIF SGFSLYVPSG TTAALVGQSG
410 420 430 440 450
SGKSTVISLL ERFYDPEAGE VLIDGVNLKK MRLRWLREQL GLVSQEPILF
460 470 480 490 500
ATTIKENILY GKSNATDSEI RTAIQLANAA KFIDKLPQGL DTMVGEHGTQ
510 520 530 540 550
LSGGQKQRIA IARAILKNPR ILLLDEATSA LDAESERIVQ DALDNVMSNR
560 570 580 590 600
TTVVVAHRLS TIRNAHLIAV VQSGKLVEQG THAELIKDPN GAYSQLIRMQ
610 620 630 640 650
QGSKDTEDSR LLDVEKLDAE IDADETLMKS PSQRMSLRRS SSRGSSRKSF
660 670 680 690 700
TFNYGIPGLV EIHETEVGED EAEGDNTDIV SHKKVSFKRL AILNKPEIPQ
710 720 730 740 750
LLLGSVAAII HGVIFPVFGL LLSKSVRIMY EPPHQLRKDA RFWCLMYVGL
760 770 780 790 800
GIITLLVLPL QNYFFGIAGG KLIERIRSLS FEKVVHQEIS WFDDSKNSSG
810 820 830 840 850
AVGARLSSDA STLRSLVGDA LALVVQNIAT VAAGLVISFT ANWILALIIL
860 870 880 890 900
AVLPLVGLQG FLQMKFYKGF SADAKVMYEE ASQVANDAVG SIRTVASFCA
910 920 930 940 950
EEKVMEMYQR KCEGPVKQGV RLGMVSGAGL GIGNGANYCA SAFCFYIGAV
960 970 980 990 1000
LVFHGKATFG EVFRVFFALT MSAMGVSQAM ALAPDVNKTK QSAASVFEIL
1010 1020 1030 1040 1050
DAKPKIDSSS NKGQTLASVK GDIELQHISF KYPTRPDIQI FKGLCLSIPC
1060 1070 1080 1090 1100
GKTVALVGES GSGKSTVISL IERFYDPDSG NIYLDGVELQ KLKISWLRQQ
1110 1120 1130 1140 1150
MGLVSQEPVL FNESIRDNIA YGKQGNATED EIIAATKASN AHSFISSLPN
1160 1170 1180 1190 1200
GYDTSVGERG VQLSGGQKQR IAIARAILKD PRILLLDEAT SALDAESERI
1210 1220 1230 1240 1250
VQDALDKVMV NRTTVVVAHR LSTIKGADVI AVVKNGVISE KGRHDELMKM
1260
ENGVYASLVS LQSSAA
Length:1,266
Mass (Da):137,063
Last modified:July 10, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i746CBA0CD4EA1FED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ660356 mRNA Translation: ABG56413.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ660356 mRNA Translation: ABG56413.1

3D structure databases

SMRiA5X7X7
ModBaseiSearch...

Protein family/group databases

TCDBi3.A.1.201.25, the atp-binding cassette (abc) superfamily

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like_ATP-bd
IPR017871, ABC_transporter-like_CS
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5X7X7_CATRO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5X7X7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: January 19, 2022
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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