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Entry version 71 (16 Jan 2019)
Sequence version 1 (10 Jul 2007)
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Protein
Submitted name:

DNA polymerase nu

Gene

poln

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: InterPro
  • DNA-directed DNA polymerase activity Source: InterPro
  • DNA polymerase activity Source: ZFIN

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA polymerase nuImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polnImported
Synonyms:POLNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-100917-1 poln

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A5X572

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini887 – 1090POLAcInterPro annotationAdd BLAST204

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili727 – 747Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPH2 Eukaryota
COG0749 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000205980

KEGG Orthology (KO)

More...
KOi
K16618

Database of Orthologous Groups

More...
OrthoDBi
105635at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A5X572

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR002298 DNA_polymerase_A
IPR036397 RNaseH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10133 PTHR10133, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00476 DNA_pol_A, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00868 DNAPOLI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00482 POLAc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5X572-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESYLCSSLN AVPLSAAAQR IISALRVQYV QKADRSRATW SDQGFGMAQQ
60 70 80 90 100
QDGEDRNVEL HSGNSRDLNL NELAEHSNSS ELEDMAIDKF ALNLPIIERF
110 120 130 140 150
VFDHADNIIT PIGQHFTPSV QGEDSLQTFC LTSMGSPQAR ADVITQSEIH
160 170 180 190 200
GRTFRKRKWI QPASPPEQDL VGCSQPETPP MKKFNFMLPI DNCQPAFGEE
210 220 230 240 250
GKMIDIVDKR NNNGQPWLPE KENSDSVSED RAAFIEVQLG SLRCISNVDM
260 270 280 290 300
ITSKCVLETS HYWEESRNCQ LSVPMENSPD AKRCESISVF ECQQDTANRS
310 320 330 340 350
DKMMDSSREK VDNGTERRDI TKLRTSSPQS DDNTVVMPVL EGEMECAASS
360 370 380 390 400
SRNAMQHSIQ PHSQAVEVTS FSKHAGKWEP PGPSQKALCK KTFRNPRFPI
410 420 430 440 450
QLFHQVNGSM RLLKQRKAPQ PMVKRQRRLL RPQKIFKSKR GKKQNKLTKT
460 470 480 490 500
SDSSLSGSKE SSHILSETDR KEDGTTTTLK GAFSLISDPR VCDTGRVSQE
510 520 530 540 550
ERECILEETG KAKAFVVTMV YQDGTTQLDS EQKLCPPVCG LLILLKSELN
560 570 580 590 600
SEEPLERPPE RVLYLRLEQT PAWAQQDFTQ KQDAYAREML LKIMCGTKTF
610 620 630 640 650
VCFKAKDLLR TVLRHFRDLS WTQVLGCQVM DPQIAAWLLD PADSSSCFQT
660 670 680 690 700
LLSKHYTHQF TPTTLQPVLE QAKVTQVISN LSLLHKLMEE LHYKLRTQGL
710 720 730 740 750
WQLYSGIEQK MIPVLAAMES YKMHVDKEAL KKTSEMLGSK LKQLEQEAHQ
760 770 780 790 800
AAGQKFLVSS SAQLRLILFE KLRLHELCEN KKLPKTVKQQ QSTSETALLQ
810 820 830 840 850
LQKLHPLPKI ILEYRQIHKI KTTFVDGILS CTRKTFISST WNQTSTVSGR
860 870 880 890 900
LSAKHPNFQA LPKLPLQISK KQYIHGKASD IVTVHPRAMF IPREGWTFLS
910 920 930 940 950
ADFCQVELRL LAHLSADPQL LRIFQSPEAD AFTMLAAQWK GVSEDRVSLE
960 970 980 990 1000
DREQAKRIVY SVVYGAGRER LSGILGVSAE EASRFQDSFL KTYREVPAFI
1010 1020 1030 1040 1050
QHTIQHCQSH GFVRSIMGRR RFLPHIHSAD WSLRNQAERQ AVNFVLQGSA
1060 1070 1080 1090 1100
ADLAKLAMIR ICSQVSSDSQ TARLVAQIHD ELLFEVEISQ LDQFAALVKK
1110 1120 1130 1140
TMESLQHIEY LNVNLSVPLK VLLSTGRSWG SMYEMNLSCT ATATSA
Length:1,146
Mass (Da):129,601
Last modified:July 10, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10F3B532B4341F44
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ630550 mRNA Translation: ABG00195.1

NCBI Reference Sequences

More...
RefSeqi
NP_001093496.1, NM_001100026.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.155330

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
566857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:566857

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ630550 mRNA Translation: ABG00195.1
RefSeqiNP_001093496.1, NM_001100026.1
UniGeneiDr.155330

3D structure databases

ProteinModelPortaliA5X572
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi566857
KEGGidre:566857

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
353497
ZFINiZDB-GENE-100917-1 poln

Phylogenomic databases

eggNOGiENOG410IPH2 Eukaryota
COG0749 LUCA
HOGENOMiHOG000205980
KOiK16618
OrthoDBi105635at2759
PhylomeDBiA5X572

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR002298 DNA_polymerase_A
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00482 POLAc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5X572_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5X572
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: January 16, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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