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Entry version 69 (07 Apr 2021)
Sequence version 1 (10 Jul 2007)
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Protein

Ectopic P granules protein 5 homolog

Gene

epg5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ectopic P granules protein 5 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:epg5
ORF Names:si:dkey-165i4.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070705-307, epg5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003062571 – 2532Ectopic P granules protein 5 homologAdd BLAST2532

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A5WUT8

PeptideAtlas

More...
PeptideAtlasi
A5WUT8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000059846, Expressed in retina and 24 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000121482

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A5WUT8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili254 – 282Sequence analysisAdd BLAST29
Coiled coili1569 – 1596Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EPG5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3622, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007354

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A5WUT8

Database of Orthologous Groups

More...
OrthoDBi
42984at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A5WUT8

TreeFam database of animal gene trees

More...
TreeFami
TF313847

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029651, EPG-5

The PANTHER Classification System

More...
PANTHERi
PTHR31139:SF4, PTHR31139:SF4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A5WUT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHLQVKKER QSESVRQPSG SSKAVNEPEF TDVPLSLPHV PPDLNTAASQ
60 70 80 90 100
TSLDHHDKAE NEQQHVLLCE KPEVVQKSTC HEDKEHELPS QDAAPRLDQT
110 120 130 140 150
SVLAPSSQSD PKPLSAKLEP FSVPSIYPSI PASLSQPQLS EDSYSISYEL
160 170 180 190 200
LDGSLMPAAS ERLVAPAVLT LANQESSPPS LVPVEVVDVE RSRERLYPEL
210 220 230 240 250
PKTCQSVKPF TSEQLRMWEP GSWLENVELH EAEFQNLAHQ EGHELYELLL
260 270 280 290 300
SYWRCRKQLT QAQTELQAAN SDCKNVQNRL WSFKDERLSL QGICADQNKV
310 320 330 340 350
YGYHCYQQVT LNEAALAELK HLFSAKAEIL HQTVALHSYT SILSRLQVES
360 370 380 390 400
YLYRLLSSNP TTKSVAVQDT SAGNPKSQPS SLQPLKESIS VLFIFTRRVL
410 420 430 440 450
DDSQFQADIH LWLQRLVSVL HQVGSTGDHL FILNHLLCCP AGVGKWAVPF
460 470 480 490 500
LQIKVLDNPS GVYHFMQALA ILMSPARHRP DFLGHMKPSD ARGNNSLTEP
510 520 530 540 550
ASGNWTLVDE GGEEDEDPET SWMLLSEDDL VSLFSQFPFD ELFKHLLGIC
560 570 580 590 600
SKGDYQPLAT TSQKMMKIFA FASSLVELLA VGLQTYNRAR YRQFVKRIGH
610 620 630 640 650
MIRMTLCYVS DHWAQYISLT GVSRTTVQEQ SFSMEKLQVE FDHLFLRAVL
660 670 680 690 700
HVLKAKRLGI WLFMSEMPYG TLSSSMLWKI FYIMQCAETD GLEKLSCSLS
710 720 730 740 750
AEDCIQRLRE SSHQERFQLW LSEINSSDGI CLLTTFAHMA QPRRTDVDPE
760 770 780 790 800
FVRNIVLEIY EVSYVSVTTR EIFSKVGREL LAAIAAAHPH IISVLLERLR
810 820 830 840 850
ETIERVGMVS LYLFKELPLH LWMPAQEEVG LIRDWLMNFS LTAVENRLAC
860 870 880 890 900
IILEGLNWGF QPNGCLILPA PLHSDVALLV IEAYQKYLTD KPYGGILSEG
910 920 930 940 950
IKQVSYLANV VRLGQTPESS FNQWAWDIVL RLKLHANERS PQDAWCPLPS
960 970 980 990 1000
SSAPSVPEIT DSPIMHPVFK AVKAGIPIGC FLAIEMTTIG HSLEKFCSEG
1010 1020 1030 1040 1050
ISLLKTLIQS RHLRAAVHIL ENILPLVYNC QFYLLKNEQF LSCVQLFLQL
1060 1070 1080 1090 1100
DSGTQGVTQQ VTQKVAQHLI GPATCENIKL LNSVIQAHVL ESSRNGRVGA
1110 1120 1130 1140 1150
VAVLEFWLQV LTEQSLWYRD RAVLFLLDHM CRSAFLHQQE ECLQKILYQQ
1160 1170 1180 1190 1200
HKSALGYHGD KGLLSSIMGW IVAGNVTPSF IEGSSLTGEV WFAWMILNME
1210 1220 1230 1240 1250
TMFEEDSQLR RCVEHELLSN PACTPDQALK KAQVRLKLQV VPSLQRLMIY
1260 1270 1280 1290 1300
RWAQQALATP ADHPILPLVW QKFFQLYLRQ PGPEFGLEVK GCIGRRYFHS
1310 1320 1330 1340 1350
AAHLSLLKSL RQRLVEVSDF HHAASKALKV PCASGDSGDG LLTPGTPITQ
1360 1370 1380 1390 1400
YMTSPDLHTE IVRLFTVFAL WLDDENLQKQ EIYLPSLPKQ YDTHRLAKIM
1410 1420 1430 1440 1450
QRQQEVWMEH VDIERVQHEL QEVLDLWSKV KSEPAVSQNS SSSIFTDFIN
1460 1470 1480 1490 1500
PLAARERILT HLRKHDAPQG SLLPVPMKAP VPDIPTASLT DEKISTTLIQ
1510 1520 1530 1540 1550
EDLTKLQHQA KLATVRETQQ VALDNELLEV LPQLYINRED QLSMQLECRG
1560 1570 1580 1590 1600
KSGQPCQGPA NITVKYSSMH KLEPVQNQIQ SLKSDIKQLQ ADGIKAPPQS
1610 1620 1630 1640 1650
LAEAAVHTEN FITALVNVFK QNPSPGVLKV GITAFYQIVS FVCEDTQRHP
1660 1670 1680 1690 1700
PTRQFFTSCI EILGQVFIRD VQSECKHMLK TILLNRRLCN LLSPYFTPNA
1710 1720 1730 1740 1750
SPSELVSLYE EVVNTLHIDS GDVIFMLLTK FDLFQWLSTT QPPFSERSRL
1760 1770 1780 1790 1800
MTVIHQALCT CGLEPEPEVL MPFNIFCKHW TELLLYQFPD HYSDFLRLLM
1810 1820 1830 1840 1850
QSSSDQLLSP DCWRTSLKAL GCSPQTKNKT NKSRSMLLSP QQVDETIEWL
1860 1870 1880 1890 1900
SKYFLKLRLS NGDFRSFGLL SKWGPYIEEV KVFWEDLITY VIDLELNHCG
1910 1920 1930 1940 1950
KEPVGSPRLL KALENLHRKM AKLFEPWILV LDTDNTSHPR CSPWLESDAA
1960 1970 1980 1990 2000
VAASLVGLYT RLTETLHEKF KDRLLPGQRG ALWLHLMFYC ETCTSPKMPE
2010 2020 2030 2040 2050
YLLYTYHTEY SRLPWKDLHP DQTLMNQFFN VERGSPKSCF VFMGELLCEV
2060 2070 2080 2090 2100
NWVSVLSDSL SPQLNPSTHT MVVSVLHLMV FLAKEDLSKP ESSVLSLLDQ
2110 2120 2130 2140 2150
SASLPWNLVD FSSYQNVTRY VSTHYPASLV LSHDTSSQQV VRLLRMAAGF
2160 2170 2180 2190 2200
EPTTQVLHHK DMTLKCQAFL HLMVQFLTSL DQNGNISLAS LETEMEKLLE
2210 2220 2230 2240 2250
NIVIFNPPET DLQQRHMATC SLFAEMLTLL NEAGISTAEG LGTKLHCWVE
2260 2270 2280 2290 2300
KRARGPLLLP LLTAACRCLA SVRHMTRTTE ACILSYFTDG CVDQYSGWGP
2310 2320 2330 2340 2350
ILVSLQVPEL TVEDFIQESL SLGSFLTLYV YILQRLNLEQ TLLNEKKTLM
2360 2370 2380 2390 2400
LLNTWISQVF PSGPADEAKL FLWWHKFLEL LQIQVDQEDA CSLDTLILTL
2410 2420 2430 2440 2450
MAFQNRLVQL GEERLNSGIL GAIGLGRKSP LSNRFRVVAR SMSAFLLVQV
2460 2470 2480 2490 2500
PSENQLRLHP GTELQLSAKA QQALSALEAM ASNKQYSELH VSVNQACQFI
2510 2520 2530
KYPNHCLRDA NTLLTLLVNA LYTDLHYLDI IR
Length:2,532
Mass (Da):286,825
Last modified:July 10, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB24637F2388AB52E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1K2R5G1K2R5_DANRE
Ectopic P granules protein 5 homolo...
epg5
2,525Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR753867 Genomic DNA Translation: CAN88788.1

NCBI Reference Sequences

More...
RefSeqi
NP_001103995.1, NM_001110525.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000144525; ENSDARP00000121482; ENSDARG00000059846

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
569543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:569543

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR753867 Genomic DNA Translation: CAN88788.1
RefSeqiNP_001103995.1, NM_001110525.1

3D structure databases

SMRiA5WUT8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000121482

Proteomic databases

PaxDbiA5WUT8
PeptideAtlasiA5WUT8

Genome annotation databases

EnsembliENSDART00000144525; ENSDARP00000121482; ENSDARG00000059846
GeneIDi569543
KEGGidre:569543

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57724
ZFINiZDB-GENE-070705-307, epg5

Phylogenomic databases

eggNOGiKOG3622, Eukaryota
GeneTreeiENSGT00390000007354
InParanoidiA5WUT8
OrthoDBi42984at2759
PhylomeDBiA5WUT8
TreeFamiTF313847

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A5WUT8

Gene expression databases

BgeeiENSDARG00000059846, Expressed in retina and 24 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR029651, EPG-5
PANTHERiPTHR31139:SF4, PTHR31139:SF4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPG5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5WUT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 10, 2007
Last modified: April 7, 2021
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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