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Entry version 112 (02 Jun 2021)
Sequence version 1 (10 Jul 2007)
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Protein

Neurogenic locus notch homolog protein 1

Gene

notch1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi383Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi386Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi403Calcium 2UniRule annotation1
Metal bindingi406Calcium 2UniRule annotation1
Metal bindingi420Calcium 2UniRule annotation1
Metal bindingi421Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi441Calcium 3UniRule annotation1
Metal bindingi442Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi444Calcium 3UniRule annotation1
Metal bindingi458Calcium 3UniRule annotation1
Metal bindingi459Calcium 3; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, Developmental proteinARBA annotation
Biological processAngiogenesisARBA annotation, DifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurogenic locus notch homolog protein 1ARBA annotation
Alternative name(s):
Notch 1 extracellular truncationARBA annotation
Notch 1 intracellular domainARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:notch1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-990415-183, notch1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 49PROSITE-ProRule annotation
Disulfide bondi80 ↔ 89PROSITE-ProRule annotation
Disulfide bondi117 ↔ 126PROSITE-ProRule annotation
Disulfide bondi157 ↔ 166PROSITE-ProRule annotation
Disulfide bondi196 ↔ 205PROSITE-ProRule annotation
Disulfide bondi234 ↔ 243PROSITE-ProRule annotation
Disulfide bondi274 ↔ 283PROSITE-ProRule annotation
Disulfide bondi312 ↔ 321PROSITE-ProRule annotation
Disulfide bondi332 ↔ 349PROSITE-ProRule annotation
Disulfide bondi351 ↔ 360PROSITE-ProRule annotation
Disulfide bondi367 ↔ 380UniRule annotation
Disulfide bondi374 ↔ 389UniRule annotation
Disulfide bondi391 ↔ 400UniRule annotation
Disulfide bondi407 ↔ 418UniRule annotation
Disulfide bondi412 ↔ 427UniRule annotation
Disulfide bondi429 ↔ 438UniRule annotation
Disulfide bondi445 ↔ 456UniRule annotation
Disulfide bondi450 ↔ 465UniRule annotation
Disulfide bondi467 ↔ 476UniRule annotation
Disulfide bondi505 ↔ 514PROSITE-ProRule annotation
Disulfide bondi521 ↔ 531PROSITE-ProRule annotation
Disulfide bondi542 ↔ 551PROSITE-ProRule annotation
Disulfide bondi580 ↔ 589PROSITE-ProRule annotation
Disulfide bondi596 ↔ 606PROSITE-ProRule annotation
Disulfide bondi617 ↔ 626PROSITE-ProRule annotation
Disulfide bondi655 ↔ 664PROSITE-ProRule annotation
Disulfide bondi671 ↔ 681PROSITE-ProRule annotation
Disulfide bondi692 ↔ 701PROSITE-ProRule annotation
Disulfide bondi730 ↔ 739PROSITE-ProRule annotation
Disulfide bondi768 ↔ 777PROSITE-ProRule annotation
Disulfide bondi789 ↔ 806PROSITE-ProRule annotation
Disulfide bondi808 ↔ 817PROSITE-ProRule annotation
Disulfide bondi846 ↔ 855PROSITE-ProRule annotation
Disulfide bondi884 ↔ 893PROSITE-ProRule annotation
Disulfide bondi922 ↔ 931PROSITE-ProRule annotation
Disulfide bondi960 ↔ 969PROSITE-ProRule annotation
Disulfide bondi998 ↔ 1007PROSITE-ProRule annotation
Disulfide bondi1036 ↔ 1045PROSITE-ProRule annotation
Disulfide bondi1063 ↔ 1073PROSITE-ProRule annotation
Disulfide bondi1084 ↔ 1093PROSITE-ProRule annotation
Disulfide bondi1122 ↔ 1131PROSITE-ProRule annotation
Disulfide bondi1160 ↔ 1169PROSITE-ProRule annotation
Disulfide bondi1206 ↔ 1215PROSITE-ProRule annotation
Disulfide bondi1222 ↔ 1232PROSITE-ProRule annotation
Disulfide bondi1243 ↔ 1252PROSITE-ProRule annotation
Disulfide bondi1284 ↔ 1293PROSITE-ProRule annotation
Disulfide bondi1322 ↔ 1331PROSITE-ProRule annotation
Disulfide bondi1344 ↔ 1361PROSITE-ProRule annotation
Disulfide bondi1363 ↔ 1372PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A5WUN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000052094, Expressed in heart and 47 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A5WUN6, baseline

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 50EGF-likeInterPro annotationAdd BLAST41
Domaini53 – 90EGF-likeInterPro annotationAdd BLAST38
Domaini91 – 127EGF-likeInterPro annotationAdd BLAST37
Domaini129 – 167EGF-likeInterPro annotationAdd BLAST39
Domaini169 – 206EGF-likeInterPro annotationAdd BLAST38
Domaini208 – 244EGF-likeInterPro annotationAdd BLAST37
Domaini246 – 284EGF-likeInterPro annotationAdd BLAST39
Domaini286 – 322EGF-likeInterPro annotationAdd BLAST37
Domaini323 – 361EGF-likeInterPro annotationAdd BLAST39
Domaini363 – 401EGF-likeInterPro annotationAdd BLAST39
Domaini403 – 439EGF-likeInterPro annotationAdd BLAST37
Domaini441 – 477EGF-likeInterPro annotationAdd BLAST37
Domaini479 – 515EGF-likeInterPro annotationAdd BLAST37
Domaini517 – 552EGF-likeInterPro annotationAdd BLAST36
Domaini554 – 590EGF-likeInterPro annotationAdd BLAST37
Domaini592 – 627EGF-likeInterPro annotationAdd BLAST36
Domaini629 – 665EGF-likeInterPro annotationAdd BLAST37
Domaini667 – 702EGF-likeInterPro annotationAdd BLAST36
Domaini704 – 740EGF-likeInterPro annotationAdd BLAST37
Domaini742 – 778EGF-likeInterPro annotationAdd BLAST37
Domaini780 – 818EGF-likeInterPro annotationAdd BLAST39
Domaini820 – 856EGF-likeInterPro annotationAdd BLAST37
Domaini858 – 894EGF-likeInterPro annotationAdd BLAST37
Domaini896 – 932EGF-likeInterPro annotationAdd BLAST37
Domaini934 – 970EGF-likeInterPro annotationAdd BLAST37
Domaini972 – 1008EGF-likeInterPro annotationAdd BLAST37
Domaini1010 – 1046EGF-likeInterPro annotationAdd BLAST37
Domaini1059 – 1094EGF-likeInterPro annotationAdd BLAST36
Domaini1096 – 1132EGF-likeInterPro annotationAdd BLAST37
Domaini1134 – 1170EGF-likeInterPro annotationAdd BLAST37
Domaini1172 – 1216EGF-likeInterPro annotationAdd BLAST45
Domaini1218 – 1253EGF-likeInterPro annotationAdd BLAST36
Domaini1255 – 1294EGF-likeInterPro annotationAdd BLAST40
Domaini1296 – 1332EGF-likeInterPro annotationAdd BLAST37
Domaini1335 – 1373EGF-likeInterPro annotationAdd BLAST39
Domaini1397 – 1437LNRInterPro annotationAdd BLAST41
Domaini1438 – 1475LNRInterPro annotationAdd BLAST38
Domaini1476 – 1519LNRInterPro annotationAdd BLAST44
Domaini1821 – 2062ANK_REP_REGIONInterPro annotationAdd BLAST242
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1876 – 1908ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1943 – 1975ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1976 – 2008ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2009 – 2041ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1718 – 1774DisorderedSequence analysisAdd BLAST57
Regioni2092 – 2135DisorderedSequence analysisAdd BLAST44
Regioni2347 – 2436DisorderedSequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1723 – 1739Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi2092 – 2106Polar residuesSequence analysisAdd BLAST15
Compositional biasi2110 – 2132Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi2347 – 2383Polar residuesSequence analysisAdd BLAST37
Compositional biasi2395 – 2436Polar residuesSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.ARBA annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157157

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000576_2_1_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022362, Notch_1
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF11936, DUF3454, 1 hit
PF00008, EGF, 22 hits
PF07645, EGF_CA, 5 hits
PF12661, hEGF, 2 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279, Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452, LNOTCHREPEAT
PR01984, NOTCH1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 35 hits
SM00179, EGF_CA, 32 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 4 hits
SSF90193, SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 23 hits
PS00022, EGF_1, 33 hits
PS01186, EGF_2, 27 hits
PS50026, EGF_3, 35 hits
PS01187, EGF_CA, 10 hits
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A5WUN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQYAGPACQF RNPCFQSPCR NGGVCRLITS ANKVDFVCNC SLGYTDRLCL
60 70 80 90 100
TPTNNVCLGA PCRNGGTCEL TSIHNYRCKC PPGWSGKTCQ QADPCASNPC
110 120 130 140 150
ANGGQCSPFD SDFLCHCTPY FSGQTCKQDV NECAQIPSPC KNGGVCENGV
160 170 180 190 200
GTYHCNCPAE YTGKHCESLY QPCNPSPCLH GGTCVQKGET SYECSCLPGF
210 220 230 240 250
SGQNCEENID DCPDHRCLNG GTCVDGVNTY NCQCKPEWTG QFCTEDVNEC
260 270 280 290 300
DLMPNSCQNG GTCLNTQGGY NCVCVNGWTG DDCSENIDDC ADAACHTGAT
310 320 330 340 350
CHDRVASFLC ECPHGRTGLL CHLDDACISN PCQKGSNCDT NPVNGKAICT
360 370 380 390 400
CPLGYVGPAC DQDVDECSLG ANPCEHAGKC INTKGSFQCK CLQGYVGARC
410 420 430 440 450
ELDINECLST PCQNDATCLD QIGGFHCICM PGYEGVFCQI NTDECASMPC
460 470 480 490 500
LNNGKCIDKI NNYQCECPTG FSGSQCQFDI DECASTPCKN GAKCMDGPNM
510 520 530 540 550
YTCQCTEGYT GQHCETDVDE CLSNPCHYGT CKDGLASFTC VCRAGFMGRL
560 570 580 590 600
CEININECLS QPCQNGGTCQ DRENAYLCVC PKGTAGANCE INLDDCQSNP
610 620 630 640 650
CDFGRCIDKI NGYECACEPG YTGKMCNINI DECAINPCHN GGTCVDGVNG
660 670 680 690 700
FTCLCREGYH DTTCQSQLNE CLSNPCIHGH CEDKVNGYNC ICDSGWSGVN
710 720 730 740 750
CDINNNECES NPCMNGGTCK DMTSGYVCTC RAGFSGPNCQ TNINECASNP
760 770 780 790 800
CLNQGTCIDD VAGYKCNCLL PYTGENCETL LAPCGSKPCK NGGVCKESED
810 820 830 840 850
YESFSCVCPA GWQGQTCEVD INECVKNPCR NDAICQNSIG SYKCSCKAGY
860 870 880 890 900
TGRNCETDID DCKPNPCSNG GFCKDAVNAF ACTCLPGFRG GRCEEDINEC
910 920 930 940 950
ESNPCKNGAN CTDCVNSYTC TCPPGFSGIH CENNTPDCTE SSCFNGGTCV
960 970 980 990 1000
DGINSFTCLC PKGFTGNYCQ HDINECDSRP CMNGGTCQDS YGTYKCTCPQ
1010 1020 1030 1040 1050
GYHGLNCQEL VNWCKPSPCK NGGICRQSGT RYSCQCQTGW TGLYCDVPSV
1060 1070 1080 1090 1100
SCEVAAKQQG VDVVRLCRNS GQCLDAGNTH YCHCQAGYTG SYCEEQVDEC
1110 1120 1130 1140 1150
IPNPCQNGAT CTDYLGGYSC ECVPGYHGVN CSDEINECLS QPCQNGGTCI
1160 1170 1180 1190 1200
DLINTYKCSC PRGTQGVHCE INIDDCTPFT DPITHEPKCF NQGRCVDRVG
1210 1220 1230 1240 1250
GYHCICPPGY VGERCEGDVN ECLSNPCGTH SCIQLKNNYR CECRTGYTGQ
1260 1270 1280 1290 1300
HCDKVFDGCK GKPCRNGGTC AVASNTPHGF ICKCPPGFTG STCEYDAHAC
1310 1320 1330 1340 1350
GSLQCKNGGT CVSGHKSPKC LCTPAFTGPE CQDPSGGHCT TNPCYNGGTC
1360 1370 1380 1390 1400
EYITEEPYYH CICPTNFNGL FCHILDWSFP GGTGQDITPA PKVSVSCEIE
1410 1420 1430 1440 1450
QCKVKKGNKI CDSACNNYAC DWDGGDCSLN FNDPWKNCSA ALQCWRYFNN
1460 1470 1480 1490 1500
GKCDEQCHNT GCLYDGFDCQ RVEAQCNPLY DQYCKDHFAD GYCDQGCNNA
1510 1520 1530 1540 1550
ECEWDGLDCA NDTPEKLAAG LLVVVVHIHP DQLRNNSFGF LRELSRVLHT
1560 1570 1580 1590 1600
NVVFRRDSKG QEMIYPYYGN EQELKKHNIK RSLDGWNDAS SDVLSSMKNS
1610 1620 1630 1640 1650
IYNIVVEGGR KRRELEKIQV KGSVVYLEID NRQCYQQTSE CFQSANDAAA
1660 1670 1680 1690 1700
FLGALASSGS LKMPYVIEAV TSEIDGPSPV ELYPVYVVLA GLALLAFVAI
1710 1720 1730 1740 1750
GMVASRKRRR EHGQLWFPEG FKTSEPSKKK RREPVGEDSV GLRPLKNCSD
1760 1770 1780 1790 1800
ISLMDDNQNE WGEEEQSDSK RFRSEEQAML DLDDQPDHRQ WTQQHLDAAD
1810 1820 1830 1840 1850
LRIPSIAPTP PQGEIENDCM DVNARGPDGF TPLMIASCSG GGLETGNSEE
1860 1870 1880 1890 1900
EEDASANVIN DFIYQGANLH NQTDRTGETA LHLAARYARS DAAKRLLEAS
1910 1920 1930 1940 1950
ADANIQDNMG RTPLHAAVAA DAQGVFQILI RNRATDLDAR MHDGTTPLIL
1960 1970 1980 1990 2000
AARLAVEGMV EELINCHADV NAIDDFGKSA LHWAAAVNNV DAAMVLLKNG
2010 2020 2030 2040 2050
ANKDMQNNKE ETPLFLAARE GSYETAKVLL EHFANREITD HMDRLPRDIA
2060 2070 2080 2090 2100
QDRMHHDIVR LIDEYNLVRS PPMHSAPLCT TLSPPLCSPN GFMGNMKPSV
2110 2120 2130 2140 2150
QSKKPRKPST KGIGCKDGKD MKVKKKKAQD GKGNLLDSSA VLSPVDSLES
2160 2170 2180 2190 2200
PHGYISDIAS PPQMTSPFQQ SPSMSLNQLQ GMSDNHMGVS HLGIGNNQDL
2210 2220 2230 2240 2250
SHIQFDPLPP RLTHLPVAGS NGSNVMNGQC EWLGRMHGSM APQNQFTAMR
2260 2270 2280 2290 2300
NASGQANLHQ SGLMTSHHNG RPATLSQMMN YQSMQNTHLM QQMQQSMQPR
2310 2320 2330 2340 2350
PQQTGVQLQS QSQNFIGGDL GGPELQQSAG NSMSIHTIIP QETQLLNPSS
2360 2370 2380 2390 2400
LGSSMAGTQF LTPPSQHSYT PALDANTPNH QLQVPDHHPF LTPSPGSPDQ
2410 2420 2430
WSSSSPNSNM SDWSEGISSP PTSMQSQIGH MPEQFK
Length:2,436
Mass (Da):263,940
Last modified:July 10, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC85D2005E2EB9DE4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QCA7F1QCA7_DANRE
Neurogenic locus notch homolog prot...
notch1b
2,465Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O93616O93616_DANRE
Notch homologue 1a
notch1b
683Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX119981 Genomic DNA No translation available.
CR396583 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000130888; ENSDARP00000105460; ENSDARG00000052094

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX119981 Genomic DNA No translation available.
CR396583 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA5WUN6

Genome annotation databases

EnsembliENSDART00000130888; ENSDARP00000105460; ENSDARG00000052094

Organism-specific databases

ZFINiZDB-GENE-990415-183, notch1b

Phylogenomic databases

GeneTreeiENSGT00940000157157
HOGENOMiCLU_000576_2_1_1

Gene expression databases

BgeeiENSDARG00000052094, Expressed in heart and 47 other tissues
ExpressionAtlasiA5WUN6, baseline

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022362, Notch_1
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF11936, DUF3454, 1 hit
PF00008, EGF, 22 hits
PF07645, EGF_CA, 5 hits
PF12661, hEGF, 2 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PIRSFiPIRSF002279, Notch, 1 hit
PRINTSiPR01452, LNOTCHREPEAT
PR01984, NOTCH1
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 35 hits
SM00179, EGF_CA, 32 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 4 hits
SSF90193, SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 23 hits
PS00022, EGF_1, 33 hits
PS01186, EGF_2, 27 hits
PS50026, EGF_3, 35 hits
PS01187, EGF_CA, 10 hits
PS50258, LNR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5WUN6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5WUN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 2, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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