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UniProtKB - A5WUE8 (A5WUE8_DANRE)
Protein
Submitted name:
E2F transcription factor 5
Gene
e2f5
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anatomical structure development Source: UniProt
- regulation of cell cycle Source: InterPro
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-DRE-1538133, G0 and Early G1 R-DRE-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DRE-69231, Cyclin D associated events in G1 |
Names & Taxonomyi
Protein namesi | Submitted name: E2F transcription factor 5Imported |
Gene namesi | Name:e2f5Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030828-3, e2f5 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- RNA polymerase II transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000038812, Expressed in testis and 27 other tissues |
ExpressionAtlasi | A5WUE8, baseline |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000056678 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 85 | E2F_TDPInterPro annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 253 – 274 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 99 – 133 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 306 – 326 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 255 – 269 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG2577, Eukaryota |
GeneTreei | ENSGT00940000157353 |
HOGENOMi | CLU_032091_2_0_1 |
InParanoidi | A5WUE8 |
OMAi | QWRGENT |
OrthoDBi | 1087250at2759 |
PhylomeDBi | A5WUE8 |
TreeFami | TF105566 |
Family and domain databases
CDDi | cd14660, E2F_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR028316, E2F5 IPR032198, E2F_CC-MB IPR003316, E2F_WHTH_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF35, PTHR12081:SF35, 1 hit |
Pfami | View protein in Pfam PF16421, E2F_CC-MB, 1 hit PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A5WUE8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAESNSASFP HSTPNGSSRH EKSLGLLTVK FVTLLQEAKD GVLDLKVAAD
60 70 80 90 100
SLAVKQKRRI YDITNVLEGI GLIEKKTKNT IQWKGESTGC QPQEVLEQVE
110 120 130 140 150
LLKANIADLE LQERELDMQK ACLQQSIKQL NEDPYSCRYS YVMHEDICDA
160 170 180 190 200
FSGDTLLAVM APSGTQLEVP VPEMGHNGQK KYQVNLRSHS APIQVMLINR
210 220 230 240 250
ETSCSKPVVV SVPPIDDISS MPTPPSTPAG LQRFPISSID LCDQKHGLLK
260 270 280 290 300
SPAAEHQLTP SSTSPDVHME CNPESPASQC LLMQSSLGGP EEQQRELGGQ
310 320 330 340 350
DLQSMLEEMR DEREGVSNLI DELMSSDVFP LLRLSPNPGV DYSFNLDDNE
360
GVCDLFDVQI LNY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6TH18 | Q6TH18_DANRE | E2F transcription factor 4, p107/p1... | e2f5 E2F4 | 143 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR293515 Genomic DNA No translation available. |
RefSeqi | NP_001184229.1, NM_001197300.1 |
Genome annotation databases
Ensembli | ENSDART00000056679; ENSDARP00000056678; ENSDARG00000038812 |
GeneIDi | 402908 |
KEGGi | dre:402908 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR293515 Genomic DNA No translation available. |
RefSeqi | NP_001184229.1, NM_001197300.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000056678 |
Proteomic databases
PaxDbi | A5WUE8 |
PeptideAtlasi | A5WUE8 |
Genome annotation databases
Ensembli | ENSDART00000056679; ENSDARP00000056678; ENSDARG00000038812 |
GeneIDi | 402908 |
KEGGi | dre:402908 |
Organism-specific databases
CTDi | 1875 |
ZFINi | ZDB-GENE-030828-3, e2f5 |
Phylogenomic databases
eggNOGi | KOG2577, Eukaryota |
GeneTreei | ENSGT00940000157353 |
HOGENOMi | CLU_032091_2_0_1 |
InParanoidi | A5WUE8 |
OMAi | QWRGENT |
OrthoDBi | 1087250at2759 |
PhylomeDBi | A5WUE8 |
TreeFami | TF105566 |
Enzyme and pathway databases
Reactomei | R-DRE-1538133, G0 and Early G1 R-DRE-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DRE-69231, Cyclin D associated events in G1 |
Gene expression databases
Bgeei | ENSDARG00000038812, Expressed in testis and 27 other tissues |
ExpressionAtlasi | A5WUE8, baseline |
Family and domain databases
CDDi | cd14660, E2F_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR028316, E2F5 IPR032198, E2F_CC-MB IPR003316, E2F_WHTH_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF35, PTHR12081:SF35, 1 hit |
Pfami | View protein in Pfam PF16421, E2F_CC-MB, 1 hit PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A5WUE8_DANRE | |
Accessioni | A5WUE8Primary (citable) accession number: A5WUE8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 10, 2007 |
Last sequence update: | July 10, 2007 | |
Last modified: | January 19, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |