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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium tuberculosis (strain F11)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:TBFG_12998
OrganismiMycobacterium tuberculosis (strain F11)
Taxonomic identifieri336982 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986981 – 2142-phospho-L-lactate guanylyltransferaseAdd BLAST214

Structurei

3D structure databases

ProteinModelPortaliA5WRN6
SMRiA5WRN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223639
KOiK14941

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

A5WRN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTPDDGDI GLIIAVKRLA AAKTRLAPVF SAQTRENVVL AMLVDTLTAA
60 70 80 90 100
AGVGSLRSIT VITPDEAAAA AAAGLGADVL ADPTPEDDPD PLNTAITAAE
110 120 130 140 150
RVVAEGASNI VVLQGDLPAL QTQELAEAIS AARHHRRSFV ADRLGTGTAV
160 170 180 190 200
LCAFGTALHP RFGPDSSARH RRSGAVELTG AWPGLRCDVD TPADLTAARQ
210
LGVGPATARA VAHR
Length:214
Mass (Da):21,819
Last modified:July 10, 2007 - v1
Checksum:i207508F4E007629E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000717 Genomic DNA Translation: ABR07325.1
RefSeqiWP_003415094.1, NZ_KK339377.1

Genome annotation databases

EnsemblBacteriaiABR07325; ABR07325; TBFG_12998
KEGGimtf:TBFG_12998
PATRICifig|336982.11.peg.3314

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000717 Genomic DNA Translation: ABR07325.1
RefSeqiWP_003415094.1, NZ_KK339377.1

3D structure databases

ProteinModelPortaliA5WRN6
SMRiA5WRN6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR07325; ABR07325; TBFG_12998
KEGGimtf:TBFG_12998
PATRICifig|336982.11.peg.3314

Phylogenomic databases

HOGENOMiHOG000223639
KOiK14941

Enzyme and pathway databases

UniPathwayi
UPA00071

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOFC_MYCTF
AccessioniPrimary (citable) accession number: A5WRN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 10, 2007
Last modified: October 10, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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