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Protein

Malate dehydrogenase

Gene

mdh

Organism
Psychrobacter sp. (strain PRwf-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei105NADUniRule annotation1
Binding sitei112NADUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Active sitei187Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 17NADUniRule annotation7
Nucleotide bindingi129 – 131NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:PsycPRwf_1873
OrganismiPsychrobacter sp. (strain PRwf-1)
Taxonomic identifieri349106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000001993 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003198461 – 327Malate dehydrogenaseAdd BLAST327

Proteomic databases

PRIDEiA5WGM2

Interactioni

Protein-protein interaction databases

STRINGi349106.PsycPRwf_1873

Structurei

3D structure databases

ProteinModelPortaliA5WGM2
SMRiA5WGM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

A5WGM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQPVRVAVT GAAGNISYAM LFRIASGEML GKDQPVILQL LEITPALDAL
60 70 80 90 100
KGVVMELEDC AFPLLAGVVQ TDDATVAFKD ADYALLVGAR PRGPGMERKD
110 120 130 140 150
LLEANAAIFS AQGKALNEVA SRDVKVLVVG NPANTNALIA QRNAPDLDPR
160 170 180 190 200
NFTAMTRLDH NRGMAQLAEE TNSTVNDVKK MIIWGNHSST QYPDLTECTV
210 220 230 240 250
NGKPALEQVD RDWYENSYIP SVQKRGAAII EARGASSAAS AANAAIAHMR
260 270 280 290 300
TWALGTDEND WVSMGVYSQG EYGIAKGLIY SFPCTCSNGD WKIVEGLDTS
310 320
SDFSQEKMKA TEQELSEERD AVEHLLP
Length:327
Mass (Da):35,366
Last modified:July 10, 2007 - v1
Checksum:i9FDD02BB8CAD08EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000713 Genomic DNA Translation: ABQ94813.1
RefSeqiWP_011961090.1, NC_009524.1

Genome annotation databases

EnsemblBacteriaiABQ94813; ABQ94813; PsycPRwf_1873
KEGGiprw:PsycPRwf_1873

Similar proteinsi

Entry informationi

Entry nameiMDH_PSYWF
AccessioniPrimary (citable) accession number: A5WGM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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