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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei192SubstrateUniRule annotation1
Binding sitei222SubstrateUniRule annotation1
Binding sitei226SubstrateUniRule annotation1
Binding sitei227NADUniRule annotation1
Binding sitei279NADUniRule annotation1
Binding sitei314NADUniRule annotation1
Binding sitei380NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi193 – 195NADUniRule annotation3
Nucleotide bindingi256 – 261NADUniRule annotation6
Nucleotide bindingi335 – 337NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:BOV_2015
OrganismiBrucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Taxonomic identifieri444178 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000006383 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000247131 – 466AdenosylhomocysteinaseAdd BLAST466

Structurei

3D structure databases

ProteinModelPortaliA5VT52
SMRiA5VT52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227986
KOiK01251
OMAiTGNRDII

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5VT52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASQDFVVK DISLADWGRK ELDIAETEMP GLMAAREEFG KSQPLKGARI
60 70 80 90 100
SGSLHMTIQT AVLIETLKVL GAEVRWASCN IFSTQDHAAA AIAATGTPVF
110 120 130 140 150
AVKGETLEEY WTYTDQIFQW PDGEPSNMIL DDGGDATMYI LIGARAEAGE
160 170 180 190 200
DVLSNPQSEE EEVLFAQIKK RMAATPGFFT KQRAAIKGVT EETTTGVNRL
210 220 230 240 250
YQLQKKGLLP FPAINVNDSV TKSKFDNKYG CKESLVDGVR RGTDVMMAGK
260 270 280 290 300
VAVVCGYGDV GKGSAQSLAG AGARVKVTEV DPICALQAAM DGFEVVTLDD
310 320 330 340 350
AASTADIVVT TTGNKDVITI DHMRKMKDMC IVGNIGHFDN EIQVAALRNL
360 370 380 390 400
KWTNVKPQVD LIEFPDGKRL ILLSEGRLLN LGNATGHPSF VMSASFTNQV
410 420 430 440 450
LGQIELFTRT DAYKNEVYVL PKHLDEKVAR LHLDKLGAKL TVLSEEQAAY
460
IGVTPQGPFK SEHYRY
Length:466
Mass (Da):50,777
Last modified:July 10, 2007 - v1
Checksum:i5F25EDD0E3480F6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000708 Genomic DNA Translation: ABQ61286.1
RefSeqiWP_006014498.1, NC_009505.1

Genome annotation databases

EnsemblBacteriaiABQ61286; ABQ61286; BOV_2015
KEGGibov:BOV_2015

Similar proteinsi

Entry informationi

Entry nameiSAHH_BRUO2
AccessioniPrimary (citable) accession number: A5VT52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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