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Protein

NAD kinase

Gene

nadK

Organism
Lactobacillus reuteri (strain DSM 20016)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei147NADUniRule annotation1
Binding sitei149NADUniRule annotation1
Binding sitei184NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 46NADUniRule annotation2
Nucleotide bindingi121 – 122NADUniRule annotation2
Nucleotide bindingi160 – 165NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Lreu_0573
OrganismiLactobacillus reuteri (strain DSM 20016)
Taxonomic identifieri557436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001991 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000598731 – 270NAD kinaseAdd BLAST270

Structurei

3D structure databases

ProteinModelPortaliA5VJ17
SMRiA5VJ17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A5VJ17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIGIYNNET AESQRVTKVL KTEMKRAGLT YVEKNPEVVI TIGGDGTLLS
60 70 80 90 100
AFHHYQKDLN NIRFVGIHTG HLGFYTDWRS FEIDDLVDSL VKDSGQAVSY
110 120 130 140 150
PLLDMKATYS DGQIENYIAL NESTIRNVTR TMVCDVFINN HLFENFRGDG
160 170 180 190 200
LCISTPTGST AYNKSVGGAI VDPNSVGFQL AEMASLNNRV FRTLGSPIIF
210 220 230 240 250
GADAELILRL RDENGHVLTC DRDQWMLKSE KERYLTELSY KVSKQRIYFA
260 270
QYRHNNFWNR VKDSFIGGVH
Length:270
Mass (Da):30,667
Last modified:July 10, 2007 - v1
Checksum:i29EED5A958A1BDCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000705 Genomic DNA Translation: ABQ82841.1
RefSeqiWP_003666883.1, NZ_AZDD01000049.1

Genome annotation databases

EnsemblBacteriaiABQ82841; ABQ82841; Lreu_0573
GeneIDi5189908
KEGGilre:Lreu_0573
PATRICifig|557436.17.peg.1490

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000705 Genomic DNA Translation: ABQ82841.1
RefSeqiWP_003666883.1, NZ_AZDD01000049.1

3D structure databases

ProteinModelPortaliA5VJ17
SMRiA5VJ17
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ82841; ABQ82841; Lreu_0573
GeneIDi5189908
KEGGilre:Lreu_0573
PATRICifig|557436.17.peg.1490

Phylogenomic databases

HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_LACRD
AccessioniPrimary (citable) accession number: A5VJ17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: October 10, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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