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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2

Gene

accD2

Organism
Roseiflexus sp. (strain RS-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2 (accD2), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1 (accD1), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi30ZincUniRule annotation1
Metal bindingi33ZincUniRule annotation1
Metal bindingi49ZincUniRule annotation1
Metal bindingi51ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 51C4-typeUniRule annotationAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciRSP357808:G1G8U-3341-MONOMER
UniPathwayi
UPA00655;UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2UniRule annotation (EC:2.1.3.15UniRule annotation)
Short name:
ACCase subunit beta 2UniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta 2UniRule annotation
Gene namesi
Name:accD2UniRule annotation
Ordered Locus Names:RoseRS_3199
OrganismiRoseiflexus sp. (strain RS-1)
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000006554 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003898411 – 300Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2Add BLAST300

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi357808.RoseRS_3199

Structurei

3D structure databases

ProteinModelPortaliA5UY57
SMRiA5UY57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 294CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 51C4-typeUniRule annotationAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4108IDZ Bacteria
COG0777 LUCA
HOGENOMiHOG000021671
KOiK01963
OMAiPEGLWIK
OrthoDBiPOG091H04JK

Family and domain databases

HAMAPiMF_01395 AcetylCoA_CT_beta, 1 hit
InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR000438 Acetyl_CoA_COase_Trfase_b_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011762 COA_CT_N
PfamiView protein in Pfam
PF01039 Carboxyl_trans, 1 hit
PRINTSiPR01070 ACCCTRFRASEB
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00515 accD, 1 hit
PROSITEiView protein in PROSITE
PS50980 COA_CT_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

A5UY57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKELIQRSRK SFTVVQSVEA DVPDNVWIKC PSCRELIYHK QLAERMKVCR
60 70 80 90 100
CGYHMRLKAR EWLALLDEDS FVEHDAHLRP ADPLGFVSPK ETYADKLREA
110 120 130 140 150
QRRTGLADVV VSGVGSIEGR RLAVAVCDFE FIGGSMGSVF GEKMARAAER
160 170 180 190 200
AAALGIPLLT INTSGGARMQ EGVIALMQLA KVNMALTRLA AARQPHIAVL
210 220 230 240 250
VDPCYGGVTA SYASVADIII AEPGASIGFA GRRVIEQTIR QKLPADFQTA
260 270 280 290 300
EFMLQHGMVD MVVPRSELHS TLAKLLRLYA AEGRATAHKS EPIVTALASL
Length:300
Mass (Da):32,755
Last modified:July 10, 2007 - v1
Checksum:i91CC51CB796C9B86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA Translation: ABQ91560.1
RefSeqiWP_011957904.1, NC_009523.1

Genome annotation databases

EnsemblBacteriaiABQ91560; ABQ91560; RoseRS_3199
KEGGirrs:RoseRS_3199

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA Translation: ABQ91560.1
RefSeqiWP_011957904.1, NC_009523.1

3D structure databases

ProteinModelPortaliA5UY57
SMRiA5UY57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357808.RoseRS_3199

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ91560; ABQ91560; RoseRS_3199
KEGGirrs:RoseRS_3199

Phylogenomic databases

eggNOGiENOG4108IDZ Bacteria
COG0777 LUCA
HOGENOMiHOG000021671
KOiK01963
OMAiPEGLWIK
OrthoDBiPOG091H04JK

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

BioCyciRSP357808:G1G8U-3341-MONOMER

Family and domain databases

HAMAPiMF_01395 AcetylCoA_CT_beta, 1 hit
InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR000438 Acetyl_CoA_COase_Trfase_b_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011762 COA_CT_N
PfamiView protein in Pfam
PF01039 Carboxyl_trans, 1 hit
PRINTSiPR01070 ACCCTRFRASEB
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00515 accD, 1 hit
PROSITEiView protein in PROSITE
PS50980 COA_CT_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACCD2_ROSS1
AccessioniPrimary (citable) accession number: A5UY57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: July 10, 2007
Last modified: June 20, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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