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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Roseiflexus sp. (strain RS-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2 (accD2), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1 (accD1), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSP357808:G1G8U-406-MONOMER
UniPathwayi
UPA00655;UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:2.1.3.15UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
Ordered Locus Names:RoseRS_0393Imported
OrganismiRoseiflexus sp. (strain RS-1)Imported
Taxonomic identifieri357808 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000006554 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi357808.RoseRS_0393

Structurei

3D structure databases

ProteinModelPortaliA5UQC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 244CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST244

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QM9 Bacteria
COG0825 LUCA
HOGENOMiHOG000273832
KOiK01962
OMAiAELYQMG
OrthoDBiPOG091H0647

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

A5UQC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTPALTPWD RVQLARHPRR PHTLDYVRAL CDDFIELHGD RRYGDDPAII
60 70 80 90 100
GGPARFADRT VMIVGHQKGS DARENVRRNF GMARPEGYRK ALRLFRHAEK
110 120 130 140 150
FGFPLICFID TPGADPSMES EERGQGNAIA ENILALAGLR VPIVACVIGE
160 170 180 190 200
GGSGGALALG VADRLLMLEH AIYSVAAPEA AASILWRDAG KAPEAASAMR
210 220 230 240 250
ITAQDQYDLG IADAIIPEPE GGAHTDAAAA AEAVGAALRA ALDALVGLPI
260 270 280
DVLLQRRYAR YRAIGRFQES QPMPNMPATV PPLPFKGS
Length:288
Mass (Da):30,945
Last modified:July 10, 2007 - v1
Checksum:i6B9413C7C7A751E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000686 Genomic DNA Translation: ABQ88824.1
RefSeqiWP_011955181.1, NC_009523.1

Genome annotation databases

EnsemblBacteriaiABQ88824; ABQ88824; RoseRS_0393
KEGGirrs:RoseRS_0393

Similar proteinsi

Entry informationi

Entry nameiA5UQC1_ROSS1
AccessioniPrimary (citable) accession number: A5UQC1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 18, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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