UniProtKB - A5UGY5 (HIS4_HAEIG)
Protein
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Gene
hisA
Organism
Haemophilus influenzae (strain PittGG)
Status
Functioni
Catalytic activityi
- 1-(5-phospho-β-D-ribosyl)-5-[(5-phospho-β-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamideUniRule annotationEC:5.3.1.16UniRule annotation
: L-histidine biosynthesis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationProteins known to be involved in the 9 steps of the subpathway in this organism are:
- ATP phosphoribosyltransferase (hisG)
- no protein annotated in this organism
- no protein annotated in this organism
- 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
- Imidazole glycerol phosphate synthase subunit HisH (hisH)
- Histidine biosynthesis bifunctional protein HisB (hisB)
- Histidinol-phosphate aminotransferase (hisC)
- Histidine biosynthesis bifunctional protein HisB (hisB)
- Histidinol dehydrogenase (hisD)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 11 | Proton acceptorUniRule annotation | 1 | |
Active sitei | 133 | Proton donorUniRule annotation | 1 |
GO - Molecular functioni
- 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-UniRule
GO - Biological processi
- histidine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase |
Biological process | Amino-acid biosynthesis, Histidine biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00031;UER00009 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)Alternative name(s): Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation |
Gene namesi | Name:hisAUniRule annotation Ordered Locus Names:CGSHiGG_05610 |
Organismi | Haemophilus influenzae (strain PittGG) |
Taxonomic identifieri | 374931 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000063211 | 1 – 249 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseAdd BLAST | 249 |
Family & Domainsi
Sequence similaritiesi
Belongs to the HisA/HisF family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_048577_1_2_6 |
OMAi | EWLHLVD |
Family and domain databases
CDDi | cd04732, HisA, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01014, HisA, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR006062, His_biosynth IPR006063, HisA IPR023016, Isoase_HisA-like IPR011060, RibuloseP-bd_barrel |
Pfami | View protein in Pfam PF00977, His_biosynth, 1 hit |
SUPFAMi | SSF51366, SSF51366, 1 hit |
TIGRFAMsi | TIGR00007, TIGR00007, 1 hit |
i Sequence
Sequence statusi: Complete.
A5UGY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQSIIIPAL DLINGQVVRL HQGDYAKQTT YSDNPIKQFD NYVRQGAKQL
60 70 80 90 100
HLVDLTGAKN PQSRQTALIG KIVEATQCKV QVGGGIRTEQ DVADLLAVGA
110 120 130 140 150
NRVVIGSTAV THRSMVKNWF IKYGAEKFVL ALDVNINASG QKIVAISGWQ
160 170 180 190 200
EESGVLLETL IEDFQTVGLQ QVLCTDISRD GTLTGSNIGL YQEICEKYPP
210 220 230 240
IQFQSSGGIG SLADIEALKG TGVSGVIVGR ALLEGKFTLS EAIKCWQNG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000672 Genomic DNA Translation: ABR00041.1 |
RefSeqi | WP_005649383.1, NC_009567.1 |
Genome annotation databases
EnsemblBacteriai | ABR00041; ABR00041; CGSHiGG_05610 |
KEGGi | hiq:CGSHiGG_05610 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000672 Genomic DNA Translation: ABR00041.1 |
RefSeqi | WP_005649383.1, NC_009567.1 |
3D structure databases
SMRi | A5UGY5 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | ABR00041; ABR00041; CGSHiGG_05610 |
KEGGi | hiq:CGSHiGG_05610 |
Phylogenomic databases
HOGENOMi | CLU_048577_1_2_6 |
OMAi | EWLHLVD |
Enzyme and pathway databases
UniPathwayi | UPA00031;UER00009 |
Family and domain databases
CDDi | cd04732, HisA, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01014, HisA, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR006062, His_biosynth IPR006063, HisA IPR023016, Isoase_HisA-like IPR011060, RibuloseP-bd_barrel |
Pfami | View protein in Pfam PF00977, His_biosynth, 1 hit |
SUPFAMi | SSF51366, SSF51366, 1 hit |
TIGRFAMsi | TIGR00007, TIGR00007, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HIS4_HAEIG | |
Accessioni | A5UGY5Primary (citable) accession number: A5UGY5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 10, 2007 | |
Last modified: | February 10, 2021 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families