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UniProtKB - A5U5H2 (A5U5H2_MYCTA)

Entry version 71 (02 Dec 2020)
Sequence version 1 (10 Jul 2007)
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Protein

Glutamate dehydrogenase

Gene

gdh

Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
LigandNADARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate dehydrogenaseARBA annotation (EC:1.4.1.2ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gdhImported
Ordered Locus Names:MRA_2501Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25177 / H37Ra)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri419947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001988 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		419947.MRA_2501

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2902, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003404_1_1_11

Identification of Orthologs from Complete Genome Data

More...OMAi		RATRWFL

Database of Orthologous Groups

More...OrthoDBi		79339at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR028971, NAD-GDH
IPR007780, NAD_Glu_DH_bac

The PANTHER Classification System

More...PANTHERi		PTHR43403, PTHR43403, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05088, Bac_GDH, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036761, GDH_Mll4104, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5U5H2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIDPGAKQD VEAWTTFTAS ADIPDWISKA YIDSYRGPRD DSSEATKAAE 
        60         70         80         90        100
ASWLPASLLT PAMLGAHYRL GRHRAAGESC VAVYRADDPA GFGPALQVVA 
       110        120        130        140        150
EHGGMLMDSV TVLLHRLGIA YAAILTPVFD VHRSPTGELL RIEPKAEGTS 
       160        170        180        190        200
PHLGEAWMHV ALSPAVDHKG LAEVERLLPK VLADVQRVAT DATALIATLS 
       210        220        230        240        250
ELAGEVESNA GGRFSAPDRQ DVGELLRWLG DGNFLLLGYQ RCRVADGMVY 
       260        270        280        290        300
GEGSSGMGVL RGRTGSRPRL TDDDKLLVLA QARVGSYLRY GAYPYAIAVR 
       310        320        330        340        350
EYVDGSVVEH RFVGLFSVAA MNADVLEIPT ISRRVREALA MAESDPSHPG 
       360        370        380        390        400
QLLLDVIQTV PRPELFTLSA QRLLTMARAV VDLGSQRQAL LFLRADRLQY 
       410        420        430        440        450
FVSCLVYMPR DRYTTAVRMQ FEDILVREFG GTRLEFTARV SESPWALMHF 
       460        470        480        490        500
MVRLPEVGVA GEGAAAPPVD VSEANRIRIQ GLLTEAARTW ADRLIGAAAA 
       510        520        530        540        550
AGSVGQADAM HYAAAFSEAY KQAVTPADAI GDIAVITELT DDSVKLVFSE 
       560        570        580        590        600
RDEQGVAQLT WFLGGRTASL SQLLPMLQSM GVVVLEERPF SVTRPDGLPV 
       610        620        630        640        650
WIYQFKISPH PTIPLAPTVA ERAATAHRFA EAVTAIWHGR VEIDRFNELV 
       660        670        680        690        700
MRAGLTWQQV VLLRAYAKYL RQAGFPYSQS YIESVLNEHP ATVRSLVDLF 
       710        720        730        740        750
EALFVPVPSG SASNRDAQAA AAAVAADIDA LVSLDTDRIL RAFASLVQAT 
       760        770        780        790        800
LRTNYFVTRQ GSARCRDVLA LKLNAQLIDE LPLPRPRYEI FVYSPRVEGV 
       810        820        830        840        850
HLRFGPVARG GLRWSDRRDD FRTEILGLVK AQAVKNAVIV PVGAKGGFVV 
       860        870        880        890        900
KRPPLPTGDP AADRDATRAE GVACYQLFIS GLLDVTDNVD HATASVNPPP 
       910        920        930        940        950
EVVRRDGDDA YLVVAADKGT ATFSDIANDV AKSYGFWLGD AFASGGSVGY 
       960        970        980        990       1000
DHKAMGITAR GAWEAVKRHF REIGIDTQTQ DFTVVGIGDM SGDVFGNGML 
      1010       1020       1030       1040       1050
LSKHIRLIAA FDHRHIFLDP NPDAAVSWAE RRRMFELPRS SWSDYDRSLI 
      1060       1070       1080       1090       1100
SEGGGVYSRE QKAIPLSAQV RAVLGIDGSV DGGAAEMAPP NLIRAILRAP 
      1110       1120       1130       1140       1150
VDLLFNGGIG TYIKAESESD ADVGDRANDP VRVNANQVRA KVIGEGGNLG 
      1160       1170       1180       1190       1200
VTALGRVEFD LSGGRINTDA LDNSAGVDCS DHEVNIKILI DSLVSAGTVK 
      1210       1220       1230       1240       1250
ADERTQLLES MTDEVAQLVL ADNEDQNDLM GTSRANAASL LPVHAMQIKY 
      1260       1270       1280       1290       1300
LVAERGVNRE LEALPSEKEI ARRSEAGIGL TSPELATLMA HVKLGLKEEV 
      1310       1320       1330       1340       1350
LATELPDQDV FASRLPRYFP TALRERFTPE IRSHQLRREI VTTMLINDLV 
      1360       1370       1380       1390       1400
DTAGITYAFR IAEDVGVTPI DAVRTYVATD AIFGVGHIWR RIRAANLPIA 
      1410       1420       1430       1440       1450
LSDRLTLDTR RLIDRAGRWL LNYRPQPLAV GAEINRFAAM VKALTPRMSE 
      1460       1470       1480       1490       1500
WLRGDDKAIV EKTAAEFASQ GVPEDLAYRV STGLYRYSLL DIIDIADIAD 
      1510       1520       1530       1540       1550
IDAAEVADTY FALMDRLGTD GLLTAVSQLP RHDRWHSLAR LAIRDDIYGA 
      1560       1570       1580       1590       1600
LRSLCFDVLA VGEPGESSEQ KIAEWEHLSA SRVARARRTL DDIRASGQKD 
      1610       1620 
LATLSVAARQ IRRMTRTSGR GISG
Length:1,624
Mass (Da):176,900
Last modified:July 10, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8ED8C54C24CCFAA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP000611 Genomic DNA Translation: ABQ74272.1

NCBI Reference Sequences

More...RefSeqi		WP_003916039.1, NZ_CP016972.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ABQ74272; ABQ74272; MRA_2501

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23491304

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mra:MRA_2501

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000611 Genomic DNA Translation: ABQ74272.1
RefSeqiWP_003916039.1, NZ_CP016972.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi419947.MRA_2501

Genome annotation databases

EnsemblBacteriaiABQ74272; ABQ74272; MRA_2501
GeneIDi23491304
KEGGimra:MRA_2501

Phylogenomic databases

eggNOGiCOG2902, Bacteria
HOGENOMiCLU_003404_1_1_11
OMAiRATRWFL
OrthoDBi79339at2

Family and domain databases

InterProiView protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR028971, NAD-GDH
IPR007780, NAD_Glu_DH_bac
PANTHERiPTHR43403, PTHR43403, 1 hit
PfamiView protein in Pfam
PF05088, Bac_GDH, 1 hit
PIRSFiPIRSF036761, GDH_Mll4104, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5U5H2_MYCTA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5U5H2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: December 2, 2020
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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