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UniProtKB - A5PN19 (A5PN19_DANRE)

Entry version 99 (02 Dec 2020)
Sequence version 1 (10 Jul 2007)
Previous versions | rss
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Protein
Submitted name:

Zgc:163098

Gene

zgc:163098

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zgc:163098Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:zgc:163098Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-070410-141, zgc:163098

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000078911, Expressed in eye and 33 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000110081

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini166 – 247RRMInterPro annotationAdd BLAST82
Domaini320 – 363SURP motifInterPro annotationAdd BLAST44
Domaini425 – 570CIDInterPro annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni271 – 292DisorderedSequence analysisAdd BLAST22
Regioni404 – 428DisorderedSequence analysisAdd BLAST25
Regioni578 – 723DisorderedSequence analysisAdd BLAST146
Regioni740 – 874DisorderedSequence analysisAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili107 – 134Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi676 – 691PolarSequence analysisAdd BLAST16
Compositional biasi692 – 706PolyampholyteSequence analysisAdd BLAST15
Compositional biasi749 – 764PolarSequence analysisAdd BLAST16
Compositional biasi765 – 835PolyampholyteSequence analysisAdd BLAST71
Compositional biasi836 – 850BasicSequence analysisAdd BLAST15
Compositional biasi857 – 874BasicSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0151, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010687

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010743_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		RRPHICA

Database of Orthologous Groups

More...OrthoDBi		523911at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A5PN19

Family and domain databases

Conserved Domains Database

More...CDDi		cd12223, RRM_SR140, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.790, 1 hit
1.25.40.90, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006569, CID_dom
IPR008942, ENTH_VHS
IPR013170, mRNA_splic_Cwf21_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR035009, SR140_RRM
IPR000061, Surp
IPR035967, SWAP/Surp_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04818, CID, 1 hit
PF08312, cwf21, 1 hit
PF00076, RRM_1, 1 hit
PF01805, Surp, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01115, cwf21, 1 hit
SM00582, RPR, 1 hit
SM00360, RRM, 1 hit
SM00648, SWAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109905, SSF109905, 1 hit
SSF48464, SSF48464, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51391, CID, 1 hit
PS50102, RRM, 1 hit
PS50128, SURP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A5PN19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKKGKSVA VKRTLTKKEQ EEMKKKEEEK AAEVFEEFLA AFDTNDKSGV 
        60         70         80         90        100
KTFVRGGIVN ATKEEEAAEV KKSKLYRPSA KFSAPLQNTS PVHHAEVKKA 
       110        120        130        140        150
VAKKKVEEKK KSNLELFKEE LKQIQEEREE RYKRKKGDSG AVFLGDLEPL 
       160        170        180        190        200
TRRSIFDDDP AVPNTTNLYI GCINPKMTEE MLCKEFGKYG PLASVKIMWP 
       210        220        230        240        250
RTEEERTRVT NRGFVAFMTR KDAERALAAL DGKTVMGFEM KLGWGKAVRI 
       260        270        280        290        300
PPQPLYTPIG VLKTTAPPPP SGLPFNAQPR DRFRNDFTKP RSRSQDDFYK 
       310        320        330        340        350
TLSEAVVTVV IPPERNLLGL IHRMIEFVVR EGPMFEAMIM NREKNNPDFR 
       360        370        380        390        400
FLFDNKSQEH VYYRWKLYSI LQGENPNNWR TSSFRMFRGG SLWKPPLLNP 
       410        420        430        440        450
YLHGDEEPEE ASFPSPEEEP KKGQLKSEHR EKLEVLLRGL TPRRDEIGDA 
       460        470        480        490        500
MLFCLERAEA AEEIVSCITE SLSIAHTPLQ KKIARLYLIS DILYNSCAKV 
       510        520        530        540        550
ANASYYRKFF ETKLPEIFGD ISEAYRNIQA RLQAEQFKQR IMGCFRAWED 
       560        570        580        590        600
WAVYPDSFLI QLQNIFLGLI KPGEEVIERP EPESPDLDGA PLDGVPLDRG 
       610        620        630        640        650
EIDGTPLDDL DGSPLTWDPS AIDGVPVDDI DGVPLGNSVD DIDGVPFDEG 
       660        670        680        690        700
SDKTLPTVAL SKWEKVDDSE SSAKNDSDNE VNSGGLKENS GDSDTSSDEA 
       710        720        730        740        750
DSPSRFEGAD FKSSLKNFEL SESKRTRLRE LEVKVMNFQD ELESGKRQRK 
       760        770        780        790        800
SSLTLQQQVQ HYRNRLLQKE FDKDDQEKRD KHSQKQKDRS KKDERRDKGE 
       810        820        830        840        850
ERSKTRDKEK SRKSEDREKS RGRSRDKEDR RERTKSRSPR KSKRSRSPSP 
       860        870 
QHKSWRSSSR SPHRSHKKSK KSKH
Length:874
Mass (Da):100,254
Last modified:July 10, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EF7C3D900C2E612
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Q5V2A0A2R8Q5V2_DANRE
Zgc:163098
zgc:163098
874Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QLY3A0A2R8QLY3_DANRE
Zgc:163098
zgc:163098
874Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QQI7F1QQI7_DANRE
Zgc:163098
zgc:163098
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q8Q5A0A2R8Q8Q5_DANRE
Zgc:163098
zgc:163098
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QHS7A0A2R8QHS7_DANRE
Zgc:163098
zgc:163098
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QSP9F1QSP9_DANRE
Zgc:163098
zgc:163098
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX927261 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001083001.2, NM_001089532.2
XP_017211492.1, XM_017356003.1
XP_017211493.1, XM_017356004.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000113642; ENSDARP00000101139; ENSDARG00000078911
ENSDART00000185506; ENSDARP00000150730; ENSDARG00000115110

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100037380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:100037380

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927261 Genomic DNA No translation available.
RefSeqiNP_001083001.2, NM_001089532.2
XP_017211492.1, XM_017356003.1
XP_017211493.1, XM_017356004.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110081

Genome annotation databases

EnsembliENSDART00000113642; ENSDARP00000101139; ENSDARG00000078911
ENSDART00000185506; ENSDARP00000150730; ENSDARG00000115110
GeneIDi100037380
KEGGidre:100037380

Organism-specific databases

ZFINiZDB-GENE-070410-141, zgc:163098

Phylogenomic databases

eggNOGiKOG0151, Eukaryota
GeneTreeiENSGT00390000010687
HOGENOMiCLU_010743_1_0_1
OMAiRRPHICA
OrthoDBi523911at2759
PhylomeDBiA5PN19

Gene expression databases

BgeeiENSDARG00000078911, Expressed in eye and 33 other tissues

Family and domain databases

CDDicd12223, RRM_SR140, 1 hit
Gene3Di1.10.10.790, 1 hit
1.25.40.90, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006569, CID_dom
IPR008942, ENTH_VHS
IPR013170, mRNA_splic_Cwf21_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR035009, SR140_RRM
IPR000061, Surp
IPR035967, SWAP/Surp_sf
PfamiView protein in Pfam
PF04818, CID, 1 hit
PF08312, cwf21, 1 hit
PF00076, RRM_1, 1 hit
PF01805, Surp, 1 hit
SMARTiView protein in SMART
SM01115, cwf21, 1 hit
SM00582, RPR, 1 hit
SM00360, RRM, 1 hit
SM00648, SWAP, 1 hit
SUPFAMiSSF109905, SSF109905, 1 hit
SSF48464, SSF48464, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51391, CID, 1 hit
PS50102, RRM, 1 hit
PS50128, SURP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5PN19_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5PN19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: December 2, 2020
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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