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Protein
Submitted name:

Platelet-derived growth factor alpha polypeptide a

Gene

pdgfaa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-114608 Platelet degranulation
R-DRE-1257604 PIP3 activates AKT signaling
R-DRE-186763 Downstream signal transduction
R-DRE-186797 Signaling by PDGF
R-DRE-3000171 Non-integrin membrane-ECM interactions
R-DRE-5673001 RAF/MAP kinase cascade
R-DRE-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Platelet-derived growth factor alpha polypeptide aImported
Gene namesi
Name:pdgfaaImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-030918-2 pdgfaa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501528554220 – 194Sequence analysisAdd BLAST175

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000055505

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095859

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 183PDGF_2InterPro annotationAdd BLAST102

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IEXJ Eukaryota
ENOG4111GMH LUCA
GeneTreeiENSGT00510000046755
HOVERGENiHBG053546
InParanoidiA5PMP7
KOiK04359
OMAiMRTWACL
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5PMP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTALIHFLV CCFSLLSAAA EEAPIPRELI ERLSNSEIHS ISDLQRILEM
60 70 80 90 100
DFLENEVLED VKQGHHKEHL YDSRNLKNLH SRRKRSIEEA VPAVCKTRTV
110 120 130 140 150
IYEIPRSQVD PTAANFLIWP PCVEVRRCSG CCNTSNMRCH PSKKHHRNVK
160 170 180 190
VAKVEYVRRR PKLREVQVQL EDHLECVCTS RHHSESRIHT ADIR
Length:194
Mass (Da):22,603
Last modified:July 10, 2007 - v1
Checksum:i49CC37696FB09795
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX072555 Genomic DNA No translation available.
BX649330 Genomic DNA No translation available.
RefSeqiNP_919407.2, NM_194426.2
XP_009294688.1, XM_009296413.2
UniGeneiDr.82131

Genome annotation databases

EnsembliENSDART00000105088; ENSDARP00000095859; ENSDARG00000110069
ENSDART00000159714; ENSDARP00000133224; ENSDARG00000115665
ENSDART00000166075; ENSDARP00000135075; ENSDARG00000109371
GeneIDi103909601
378480
KEGGidre:103909601
dre:378480

Similar proteinsi

Entry informationi

Entry nameiA5PMP7_DANRE
AccessioniPrimary (citable) accession number: A5PMP7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 18, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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