UniProtKB - A5PMG7 (A5PMG7_DANRE)
Protein
Neugrin
Gene
ngrn
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.ARBA annotation
Names & Taxonomyi
Protein namesi | Recommended name: NeugrinARBA annotationAlternative name(s): Neurite outgrowth-associated proteinARBA annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060503-19, ngrn |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane ARBA annotation
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Nucleus
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSDARG00000061314, Expressed in multi-cellular organism and 25 other tissues |
Interactioni
Subunit structurei
Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA.
Interacts with 16S mt-rRNA; this interaction is direct.
ARBA annotationProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000112143 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 176 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the neugrin family.ARBA annotation
Phylogenomic databases
eggNOGi | ENOG502S5A6, Eukaryota |
GeneTreei | ENSGT00390000014472 |
HOGENOMi | CLU_076903_0_0_1 |
InParanoidi | A5PMG7 |
OMAi | RNFLYRI |
TreeFami | TF324463 |
Family and domain databases
InterProi | View protein in InterPro IPR010487, NGRN/Rrg9 |
PANTHERi | PTHR13475, PTHR13475, 1 hit |
Pfami | View protein in Pfam PF06413, Neugrin, 1 hit |
i Sequence
Sequence statusi: Complete.
A5PMG7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSPWRRVLM LATKLAPVPG PAVCQARRHA SRGSFGWMSK NPKQKQQGAV
60 70 80 90 100
FEDDHDMDAV EVKLDSIICE ERRRQKAAKF HIIKRKMNTP GAPHRKLSWD
110 120 130 140 150
AIEQIRYLKQ ESPEEWTLQR LAEGFSVSPD VISRVLRSTF TPPAARKLKQ
160 170 180 190 200
DAKVSPSSGP QYLKDGKAEQ SRLQKSLTPS VLLPSANTSH SALKTLDTKQ
210 220 230 240 250
TGLTPSAGHI TLSKQTAVLN VAPEYQDRLE SKGEMDVNDD VEFEEEWDGV
260 270 280
ILTDEELEKI TQTLHEKPSP VEQRGRDFFD SEGNFLYRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX470135 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000123300; ENSDARP00000112143; ENSDARG00000061314 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX470135 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000112143 |
Proteomic databases
PaxDbi | A5PMG7 |
PeptideAtlasi | A5PMG7 |
Genome annotation databases
Ensembli | ENSDART00000123300; ENSDARP00000112143; ENSDARG00000061314 |
Organism-specific databases
ZFINi | ZDB-GENE-060503-19, ngrn |
Phylogenomic databases
eggNOGi | ENOG502S5A6, Eukaryota |
GeneTreei | ENSGT00390000014472 |
HOGENOMi | CLU_076903_0_0_1 |
InParanoidi | A5PMG7 |
OMAi | RNFLYRI |
TreeFami | TF324463 |
Gene expression databases
Bgeei | ENSDARG00000061314, Expressed in multi-cellular organism and 25 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR010487, NGRN/Rrg9 |
PANTHERi | PTHR13475, PTHR13475, 1 hit |
Pfami | View protein in Pfam PF06413, Neugrin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A5PMG7_DANRE | |
Accessioni | A5PMG7Primary (citable) accession number: A5PMG7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 10, 2007 |
Last sequence update: | July 10, 2007 | |
Last modified: | April 7, 2021 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |