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Protein

Trafficking protein particle complex subunit 13

Gene

TRAPPC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 13
Gene namesi
Name:TRAPPC13
Synonyms:C5orf44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113597.17
HGNCiHGNC:25828 TRAPPC13
neXtProtiNX_A5PLN9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113597
PharmGKBiPA162380280

Polymorphism and mutation databases

BioMutaiTRAPPC13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215471 – 417Trafficking protein particle complex subunit 13Add BLAST417

Proteomic databases

MaxQBiA5PLN9
PaxDbiA5PLN9
PRIDEiA5PLN9
ProteomicsDBi744
745 [A5PLN9-2]
746 [A5PLN9-4]
747 [A5PLN9-5]
748 [A5PLN9-7]

PTM databases

iPTMnetiA5PLN9
PhosphoSitePlusiA5PLN9

Expressioni

Gene expression databases

BgeeiENSG00000113597 Expressed in 210 organ(s), highest expression level in caudate nucleus
CleanExiHS_C5orf44
ExpressionAtlasiA5PLN9 baseline and differential
GenevisibleiA5PLN9 HS

Organism-specific databases

HPAiHPA037777

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) complex.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123063, 30 interactors
DIPiDIP-48284N
IntActiA5PLN9, 18 interactors
MINTiA5PLN9
STRINGi9606.ENSP00000409231

Structurei

3D structure databases

ProteinModelPortaliA5PLN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAPPC13 family.Curated

Phylogenomic databases

eggNOGiKOG2625 Eukaryota
ENOG410XSJK LUCA
GeneTreeiENSGT00390000015280
HOGENOMiHOG000029668
HOVERGENiHBG107638
InParanoidiA5PLN9
KOiK20310
OMAiTYLQPMD
OrthoDBiEOG091G090D
PhylomeDBiA5PLN9
TreeFamiTF314898

Family and domain databases

InterProiView protein in InterPro
IPR010378 DUF974
PANTHERiPTHR13134 PTHR13134, 1 hit
PfamiView protein in Pfam
PF06159 DUF974, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A5PLN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP
60 70 80 90 100
STVNGAEVLM LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK
110 120 130 140 150
ADLQTSSQRL NLSASNAAVA ELKPDCCIDD VIHHEVKEIG THILVCAVSY
160 170 180 190 200
TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN AESDLSSVTD EVFLEAQIQN
210 220 230 240 250
MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR AYLQPMDTRQ
260 270 280 290 300
YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA
310 320 330 340 350
PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERTMDLV LEMCNTNSIH
360 370 380 390 400
WCGISGRQLG KLHPSSSLCL ALTLLSSVQG LQSISGLRLT DTFLKRTYEY
410
DDIAQVCVVS SAIKVES
Length:417
Mass (Da):46,524
Last modified:February 26, 2008 - v2
Checksum:i7E80D7B11511DC6E
GO
Isoform 2 (identifier: A5PLN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.

Show »
Length:411
Mass (Da):45,935
Checksum:i4F8957F04D4ADDC8
GO
Isoform 3 (identifier: A5PLN9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
     332-332: C → CS

Show »
Length:412
Mass (Da):46,022
Checksum:i4C9D6D1C407AD42B
GO
Isoform 4 (identifier: A5PLN9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-332: C → CS

Show »
Length:418
Mass (Da):46,611
Checksum:iA70C649C01228F2A
GO
Isoform 5 (identifier: A5PLN9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
     300-315: APGYGDVRLSLEAIPD → VSLEKTSLGFWCVKDR
     316-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:309
Mass (Da):34,884
Checksum:iD7AE8E83451A6FBE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBF8H0YBF8_HUMAN
Trafficking protein particle comple...
TRAPPC13
53Annotation score:
D6RB83D6RB83_HUMAN
Trafficking protein particle comple...
TRAPPC13
81Annotation score:

Sequence cautioni

The sequence AAH47475 differs from that shown. Wrong choice of CDS.Curated
The sequence BAB14633 differs from that shown. Reason: Erroneous termination at position 63. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177K → R in AAY88966 (Ref. 6) Curated1
Sequence conflicti255L → P in AAY88966 (Ref. 6) Curated1
Sequence conflicti403I → V in AAI42995 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038356183 – 188Missing in isoform 2, isoform 3 and isoform 5. 2 Publications6
Alternative sequenceiVSP_038357300 – 315APGYG…EAIPD → VSLEKTSLGFWCVKDR in isoform 5. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_038358316 – 417Missing in isoform 5. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_038359332C → CS in isoform 3 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713699 mRNA Translation: CAD28498.1
BX641157 mRNA Translation: CAE46070.1
AK023673 mRNA Translation: BAB14633.1 Sequence problems.
AC008560 Genomic DNA No translation available.
CH471137 Genomic DNA Translation: EAW51346.1
BC047475 mRNA Translation: AAH47475.1 Sequence problems.
BC117128 mRNA Translation: AAI17129.1
BC142994 mRNA Translation: AAI42995.1
DQ088673 mRNA Translation: AAY88966.1
CCDSiCCDS47221.1 [A5PLN9-5]
CCDS47222.1 [A5PLN9-1]
CCDS47223.1 [A5PLN9-2]
CCDS58950.1 [A5PLN9-4]
RefSeqiNP_001087224.1, NM_001093755.1 [A5PLN9-5]
NP_001087225.1, NM_001093756.1 [A5PLN9-2]
NP_001230666.1, NM_001243737.1 [A5PLN9-4]
NP_079217.2, NM_024941.3 [A5PLN9-1]
UniGeneiHs.591760

Genome annotation databases

EnsembliENST00000231526; ENSP00000231526; ENSG00000113597 [A5PLN9-2]
ENST00000399438; ENSP00000382367; ENSG00000113597 [A5PLN9-1]
ENST00000438419; ENSP00000409231; ENSG00000113597 [A5PLN9-5]
ENST00000505553; ENSP00000423405; ENSG00000113597 [A5PLN9-4]
GeneIDi80006
KEGGihsa:80006
UCSCiuc003jtz.5 human [A5PLN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713699 mRNA Translation: CAD28498.1
BX641157 mRNA Translation: CAE46070.1
AK023673 mRNA Translation: BAB14633.1 Sequence problems.
AC008560 Genomic DNA No translation available.
CH471137 Genomic DNA Translation: EAW51346.1
BC047475 mRNA Translation: AAH47475.1 Sequence problems.
BC117128 mRNA Translation: AAI17129.1
BC142994 mRNA Translation: AAI42995.1
DQ088673 mRNA Translation: AAY88966.1
CCDSiCCDS47221.1 [A5PLN9-5]
CCDS47222.1 [A5PLN9-1]
CCDS47223.1 [A5PLN9-2]
CCDS58950.1 [A5PLN9-4]
RefSeqiNP_001087224.1, NM_001093755.1 [A5PLN9-5]
NP_001087225.1, NM_001093756.1 [A5PLN9-2]
NP_001230666.1, NM_001243737.1 [A5PLN9-4]
NP_079217.2, NM_024941.3 [A5PLN9-1]
UniGeneiHs.591760

3D structure databases

ProteinModelPortaliA5PLN9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123063, 30 interactors
DIPiDIP-48284N
IntActiA5PLN9, 18 interactors
MINTiA5PLN9
STRINGi9606.ENSP00000409231

PTM databases

iPTMnetiA5PLN9
PhosphoSitePlusiA5PLN9

Polymorphism and mutation databases

BioMutaiTRAPPC13

Proteomic databases

MaxQBiA5PLN9
PaxDbiA5PLN9
PRIDEiA5PLN9
ProteomicsDBi744
745 [A5PLN9-2]
746 [A5PLN9-4]
747 [A5PLN9-5]
748 [A5PLN9-7]

Protocols and materials databases

DNASUi80006
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231526; ENSP00000231526; ENSG00000113597 [A5PLN9-2]
ENST00000399438; ENSP00000382367; ENSG00000113597 [A5PLN9-1]
ENST00000438419; ENSP00000409231; ENSG00000113597 [A5PLN9-5]
ENST00000505553; ENSP00000423405; ENSG00000113597 [A5PLN9-4]
GeneIDi80006
KEGGihsa:80006
UCSCiuc003jtz.5 human [A5PLN9-1]

Organism-specific databases

CTDi80006
EuPathDBiHostDB:ENSG00000113597.17
GeneCardsiTRAPPC13
H-InvDBiHIX0018533
HGNCiHGNC:25828 TRAPPC13
HPAiHPA037777
neXtProtiNX_A5PLN9
OpenTargetsiENSG00000113597
PharmGKBiPA162380280
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2625 Eukaryota
ENOG410XSJK LUCA
GeneTreeiENSGT00390000015280
HOGENOMiHOG000029668
HOVERGENiHBG107638
InParanoidiA5PLN9
KOiK20310
OMAiTYLQPMD
OrthoDBiEOG091G090D
PhylomeDBiA5PLN9
TreeFamiTF314898

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTRAPPC13 human
GenomeRNAii80006
PROiPR:A5PLN9

Gene expression databases

BgeeiENSG00000113597 Expressed in 210 organ(s), highest expression level in caudate nucleus
CleanExiHS_C5orf44
ExpressionAtlasiA5PLN9 baseline and differential
GenevisibleiA5PLN9 HS

Family and domain databases

InterProiView protein in InterPro
IPR010378 DUF974
PANTHERiPTHR13134 PTHR13134, 1 hit
PfamiView protein in Pfam
PF06159 DUF974, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPC13_HUMAN
AccessioniPrimary (citable) accession number: A5PLN9
Secondary accession number(s): Q17RZ9
, Q49A23, Q4JHG0, Q6MZG4, Q8TCM2, Q9H8I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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