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Protein

Protein FAM149A

Gene

FAM149A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM149A
Gene namesi
Name:FAM149A
ORF Names:MST119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109794.13
HGNCiHGNC:24527 FAM149A
neXtProtiNX_A5PLN7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109794
PharmGKBiPA162386366

Polymorphism and mutation databases

BioMutaiFAM149A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199301 – 773Protein FAM149AAdd BLAST773

Proteomic databases

PaxDbiA5PLN7
PRIDEiA5PLN7
ProteomicsDBi740
741 [A5PLN7-2]
742 [A5PLN7-3]
743 [A5PLN7-4]

PTM databases

iPTMnetiA5PLN7
PhosphoSitePlusiA5PLN7

Expressioni

Gene expression databases

BgeeiENSG00000109794 Expressed in 205 organ(s), highest expression level in nucleus accumbens
CleanExiHS_FAM149A
ExpressionAtlasiA5PLN7 baseline and differential
GenevisibleiA5PLN7 HS

Organism-specific databases

HPAiHPA044019
HPA055004

Interactioni

Protein-protein interaction databases

BioGridi117378, 1 interactor
STRINGi9606.ENSP00000227065

Structurei

3D structure databases

ProteinModelPortaliA5PLN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 37Poly-Ala4
Compositional biasi98 – 149Pro-richAdd BLAST52
Compositional biasi228 – 281Ser-richAdd BLAST54

Sequence similaritiesi

Belongs to the FAM149 family.Curated

Phylogenomic databases

eggNOGiENOG410IE96 Eukaryota
ENOG410ZYXN LUCA
GeneTreeiENSGT00530000063727
HOGENOMiHOG000112437
HOVERGENiHBG107111
InParanoidiA5PLN7
OMAiRPTYFAD
OrthoDBiEOG091G05T8
PhylomeDBiA5PLN7
TreeFamiTF330725

Family and domain databases

InterProiView protein in InterPro
IPR022194 DUF3719
IPR039630 FAM149
PANTHERiPTHR31997 PTHR31997, 1 hit
PfamiView protein in Pfam
PF12516 DUF3719, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A5PLN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT
60 70 80 90 100
APTLLRALAP DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS
110 120 130 140 150
PRAGKAPPQP PTPSGGGCSP ARLVVPARPP SGPGGVWAAL PRNPLQPGPG
160 170 180 190 200
ERELGACVAP GAGPRTLFLT LPDIGEEGAS DGDSGDGEAR GLSEGRRRHG
210 220 230 240 250
FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP TGAHTSWSGS
260 270 280 290 300
ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP
310 320 330 340 350
QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP
360 370 380 390 400
LSACGHSSNI RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE
410 420 430 440 450
VYHVDGKIEE YFAFDRKEDD DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK
460 470 480 490 500
DAVAAEVFDH VWTNMVELLE ELIRKHWETT LTEGKKQRET LKVAGNRFPH
510 520 530 540 550
VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS SFYSDMNGVM
560 570 580 590 600
TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL
610 620 630 640 650
SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL
660 670 680 690 700
VQTSRSRFPP LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS
710 720 730 740 750
RLRERTATLE RLSRPSTTHT FRQSDTPRKS SLTQMEFAAH TWTGQSILTG
760 770
SQYVPKSFQR TTLTFKRRFQ VTS
Length:773
Mass (Da):82,698
Last modified:February 26, 2008 - v2
Checksum:i287183E70F1901E5
GO
Isoform 2 (identifier: A5PLN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.

Show »
Length:482
Mass (Da):53,250
Checksum:i7B976B1F92E4661C
GO
Isoform 3 (identifier: A5PLN7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     723-723: Missing.

Show »
Length:772
Mass (Da):82,569
Checksum:iA82BA8F493E45281
GO
Isoform 4 (identifier: A5PLN7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-235: Missing.

Note: No experimental confirmation available.
Show »
Length:764
Mass (Da):81,787
Checksum:i1F673FAE56038E4F
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RC92D6RC92_HUMAN
Protein FAM149A
FAM149A
76Annotation score:
A0A0A0MRZ3A0A0A0MRZ3_HUMAN
Protein FAM149A
FAM149A
402Annotation score:
H0Y965H0Y965_HUMAN
Protein FAM149A
FAM149A
147Annotation score:
D6RAL4D6RAL4_HUMAN
Protein FAM149A
FAM149A
61Annotation score:
H0Y909H0Y909_HUMAN
Protein FAM149A
FAM149A
159Annotation score:
D6RGX1D6RGX1_HUMAN
Protein FAM149A
FAM149A
36Annotation score:
H0Y8Y9H0Y8Y9_HUMAN
Protein FAM149A
FAM149A
53Annotation score:

Sequence cautioni

The sequence AAI10817 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ13641 differs from that shown. Reason: Frameshift at position 635.Curated
The sequence AAQ13641 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti431P → L in CAB45695 (PubMed:17974005).Curated1
Sequence conflicti635R → G in AAQ13641 (Ref. 3) Curated1
Sequence conflicti644D → N in AAI42993 (PubMed:15489334).Curated1
Sequence conflicti730S → G in CAB45695 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039050332K → E1 PublicationCorresponds to variant dbSNP:rs4862650Ensembl.1
Natural variantiVAR_039051437K → E2 PublicationsCorresponds to variant dbSNP:rs4862653Ensembl.1
Natural variantiVAR_039052505H → R2 PublicationsCorresponds to variant dbSNP:rs2276924Ensembl.1
Natural variantiVAR_039053532P → L. Corresponds to variant dbSNP:rs2276922Ensembl.1
Natural variantiVAR_039054722R → W. Corresponds to variant dbSNP:rs9991339Ensembl.1
Natural variantiVAR_039055748L → V. Corresponds to variant dbSNP:rs6818265Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0315301 – 291Missing in isoform 2. 1 PublicationAdd BLAST291
Alternative sequenceiVSP_031531227 – 235Missing in isoform 4. Curated9
Alternative sequenceiVSP_031532723Missing in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104070 Genomic DNA No translation available.
AC110771 Genomic DNA No translation available.
BC110816 mRNA Translation: AAI10817.1 Different initiation.
BC142992 mRNA Translation: AAI42993.1
AF173894 mRNA Translation: AAQ13641.1 Sequence problems.
AL080065 mRNA Translation: CAB45695.2
CCDSiCCDS34117.1 [A5PLN7-2]
PIRiT12464
RefSeqiNP_001006656.1, NM_001006655.2 [A5PLN7-2]
NP_056213.1, NM_015398.2 [A5PLN7-2]
XP_016863486.1, XM_017007997.1
XP_016863491.1, XM_017008002.1
XP_016863492.1, XM_017008003.1
XP_016863493.1, XM_017008004.1
XP_016863494.1, XM_017008005.1
UniGeneiHs.744961

Genome annotation databases

EnsembliENST00000227065; ENSP00000227065; ENSG00000109794 [A5PLN7-2]
ENST00000356371; ENSP00000348732; ENSG00000109794 [A5PLN7-1]
ENST00000502970; ENSP00000427155; ENSG00000109794 [A5PLN7-2]
ENST00000503432; ENSP00000426835; ENSG00000109794 [A5PLN7-2]
ENST00000514153; ENSP00000424380; ENSG00000109794 [A5PLN7-2]
GeneIDi25854
KEGGihsa:25854
UCSCiuc003iyt.5 human [A5PLN7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104070 Genomic DNA No translation available.
AC110771 Genomic DNA No translation available.
BC110816 mRNA Translation: AAI10817.1 Different initiation.
BC142992 mRNA Translation: AAI42993.1
AF173894 mRNA Translation: AAQ13641.1 Sequence problems.
AL080065 mRNA Translation: CAB45695.2
CCDSiCCDS34117.1 [A5PLN7-2]
PIRiT12464
RefSeqiNP_001006656.1, NM_001006655.2 [A5PLN7-2]
NP_056213.1, NM_015398.2 [A5PLN7-2]
XP_016863486.1, XM_017007997.1
XP_016863491.1, XM_017008002.1
XP_016863492.1, XM_017008003.1
XP_016863493.1, XM_017008004.1
XP_016863494.1, XM_017008005.1
UniGeneiHs.744961

3D structure databases

ProteinModelPortaliA5PLN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117378, 1 interactor
STRINGi9606.ENSP00000227065

PTM databases

iPTMnetiA5PLN7
PhosphoSitePlusiA5PLN7

Polymorphism and mutation databases

BioMutaiFAM149A

Proteomic databases

PaxDbiA5PLN7
PRIDEiA5PLN7
ProteomicsDBi740
741 [A5PLN7-2]
742 [A5PLN7-3]
743 [A5PLN7-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227065; ENSP00000227065; ENSG00000109794 [A5PLN7-2]
ENST00000356371; ENSP00000348732; ENSG00000109794 [A5PLN7-1]
ENST00000502970; ENSP00000427155; ENSG00000109794 [A5PLN7-2]
ENST00000503432; ENSP00000426835; ENSG00000109794 [A5PLN7-2]
ENST00000514153; ENSP00000424380; ENSG00000109794 [A5PLN7-2]
GeneIDi25854
KEGGihsa:25854
UCSCiuc003iyt.5 human [A5PLN7-1]

Organism-specific databases

CTDi25854
EuPathDBiHostDB:ENSG00000109794.13
GeneCardsiFAM149A
H-InvDBiHIX0031434
HGNCiHGNC:24527 FAM149A
HPAiHPA044019
HPA055004
neXtProtiNX_A5PLN7
OpenTargetsiENSG00000109794
PharmGKBiPA162386366
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE96 Eukaryota
ENOG410ZYXN LUCA
GeneTreeiENSGT00530000063727
HOGENOMiHOG000112437
HOVERGENiHBG107111
InParanoidiA5PLN7
OMAiRPTYFAD
OrthoDBiEOG091G05T8
PhylomeDBiA5PLN7
TreeFamiTF330725

Miscellaneous databases

ChiTaRSiFAM149A human
GenomeRNAii25854
PROiPR:A5PLN7

Gene expression databases

BgeeiENSG00000109794 Expressed in 205 organ(s), highest expression level in nucleus accumbens
CleanExiHS_FAM149A
ExpressionAtlasiA5PLN7 baseline and differential
GenevisibleiA5PLN7 HS

Family and domain databases

InterProiView protein in InterPro
IPR022194 DUF3719
IPR039630 FAM149
PANTHERiPTHR31997 PTHR31997, 1 hit
PfamiView protein in Pfam
PF12516 DUF3719, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF149A_HUMAN
AccessioniPrimary (citable) accession number: A5PLN7
Secondary accession number(s): B5MDB8
, Q2TAN6, Q7Z2S5, Q9Y4T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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