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Protein

Transmembrane protein 189

Gene

TMEM189

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 189
Gene namesi
Name:TMEM189Imported
Synonyms:KUA1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000240849.10
HGNCiHGNC:16735 TMEM189
MIMi610994 gene
neXtProtiNX_A5PLL7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi387521
387522
7335
OpenTargetsiENSG00000240849
PharmGKBiPA162406226

Polymorphism and mutation databases

BioMutaiTMEM189

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199931 – 270Transmembrane protein 189Add BLAST270

Proteomic databases

EPDiA5PLL7
MaxQBiA5PLL7
PRIDEiA5PLL7
ProteomicsDBi739

PTM databases

iPTMnetiA5PLL7
PhosphoSitePlusiA5PLL7
SwissPalmiA5PLL7

Expressioni

Gene expression databases

BgeeiENSG00000240849 Expressed in 185 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiA5PLL7 baseline and differential
GenevisibleiA5PLL7 HS

Organism-specific databases

HPAiHPA059549

Interactioni

Protein-protein interaction databases

BioGridi132320, 22 interactors
132321, 17 interactors
IntActiA5PLL7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliA5PLL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00740000115607
HOGENOMiHOG000257103
HOVERGENiHBG058716
InParanoidiA5PLL7
KOiK20656
OMAiRTQECIC
OrthoDBiEOG091G0SMT
PhylomeDBiA5PLL7

Family and domain databases

InterProiView protein in InterPro
IPR019547 TMEM189_B_dmain
PfamiView protein in Pfam
PF10520 TMEM189_B_dmain, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A5PLL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAENWPGQ QLELDEDEAS CCRWGAQHAG ARELAALYSP GKRLQEWCSV
60 70 80 90 100
ILCFSLIAHN LVHLLLLARW EDTPLVILGV VAGALIADFL SGLVHWGADT
110 120 130 140 150
WGSVELPIVG KAFIRPFREH HIDPTAITRH DFIETNGDNC LVTLLPLLNM
160 170 180 190 200
AYKFRTHSPE ALEQLYPWEC FVFCLIIFGT FTNQIHKWSH TYFGLPRWVT
210 220 230 240 250
LLQDWHVILP RKHHRIHHVS PHETYFCITT GWLNYPLEKI GFWRRLEDLI
260 270
QGLTGEKPRA DDMKWAQKIK
Length:270
Mass (Da):31,135
Last modified:November 2, 2010 - v3
Checksum:i960E639B6F1B55ED
GO
Isoform 2 (identifier: A5PLL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-111: Missing.

Show »
Length:267
Mass (Da):30,851
Checksum:i7470903C736C4016
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TGE2Q5TGE2_HUMAN
HCG2044780, isoform CRA_b
TMEM189 hCG_2044780
195Annotation score:
F8WBY2F8WBY2_HUMAN
Transmembrane protein 189
TMEM189
45Annotation score:
F8W924F8W924_HUMAN
Transmembrane protein 189
TMEM189
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6N → D in AAF08702 (PubMed:11076860).Curated1
Sequence conflicti6N → D in BAB18652 (PubMed:11280764).Curated1
Sequence conflicti6N → D in BAB14364 (PubMed:11780052).Curated1
Sequence conflicti6N → D in AAI42967 (PubMed:15489334).Curated1
Sequence conflicti121H → N in AAI42967 (PubMed:15489334).Curated1
Sequence conflicti167P → H in AAI42967 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0597327W → G. Corresponds to variant dbSNP:rs2026757Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054091109 – 111Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155120 mRNA Translation: AAF08702.1
AB044550 mRNA Translation: BAB18652.1
AK023028 mRNA Translation: BAB14364.1
AL034423 Genomic DNA No translation available.
BC142966 mRNA Translation: AAI42967.1
CCDSiCCDS13428.1 [A5PLL7-1]
CCDS54473.1 [A5PLL7-2]
RefSeqiNP_001155977.1, NM_001162505.1
NP_954580.1, NM_199129.2
NP_954673.1, NM_199203.2
UniGeneiHs.744839

Genome annotation databases

EnsembliENST00000371650; ENSP00000360713; ENSG00000240849 [A5PLL7-2]
ENST00000371652; ENSP00000360715; ENSG00000240849 [A5PLL7-1]
GeneIDi387521
387522
KEGGihsa:387521
hsa:387522
UCSCiuc002xvg.3 human [A5PLL7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155120 mRNA Translation: AAF08702.1
AB044550 mRNA Translation: BAB18652.1
AK023028 mRNA Translation: BAB14364.1
AL034423 Genomic DNA No translation available.
BC142966 mRNA Translation: AAI42967.1
CCDSiCCDS13428.1 [A5PLL7-1]
CCDS54473.1 [A5PLL7-2]
RefSeqiNP_001155977.1, NM_001162505.1
NP_954580.1, NM_199129.2
NP_954673.1, NM_199203.2
UniGeneiHs.744839

3D structure databases

ProteinModelPortaliA5PLL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132320, 22 interactors
132321, 17 interactors
IntActiA5PLL7, 1 interactor

PTM databases

iPTMnetiA5PLL7
PhosphoSitePlusiA5PLL7
SwissPalmiA5PLL7

Polymorphism and mutation databases

BioMutaiTMEM189

Proteomic databases

EPDiA5PLL7
MaxQBiA5PLL7
PRIDEiA5PLL7
ProteomicsDBi739

Protocols and materials databases

DNASUi387522
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371650; ENSP00000360713; ENSG00000240849 [A5PLL7-2]
ENST00000371652; ENSP00000360715; ENSG00000240849 [A5PLL7-1]
GeneIDi387521
387522
KEGGihsa:387521
hsa:387522
UCSCiuc002xvg.3 human [A5PLL7-1]

Organism-specific databases

CTDi387521
387522
DisGeNETi387521
387522
7335
EuPathDBiHostDB:ENSG00000240849.10
GeneCardsiTMEM189
HGNCiHGNC:16735 TMEM189
HPAiHPA059549
MIMi610994 gene
neXtProtiNX_A5PLL7
OpenTargetsiENSG00000240849
PharmGKBiPA162406226
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00740000115607
HOGENOMiHOG000257103
HOVERGENiHBG058716
InParanoidiA5PLL7
KOiK20656
OMAiRTQECIC
OrthoDBiEOG091G0SMT
PhylomeDBiA5PLL7

Miscellaneous databases

GeneWikiiKua-UEV
PROiPR:A5PLL7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000240849 Expressed in 185 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiA5PLL7 baseline and differential
GenevisibleiA5PLL7 HS

Family and domain databases

InterProiView protein in InterPro
IPR019547 TMEM189_B_dmain
PfamiView protein in Pfam
PF10520 TMEM189_B_dmain, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM189_HUMAN
AccessioniPrimary (citable) accession number: A5PLL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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