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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi97Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi100Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi112Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi185Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi188Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi191Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi195Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei200Ubiquinone; shared with dhsdBy similarity1
Metal bindingi242Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi248Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi252Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-71403 Citric acid cycle (TCA cycle)
UniPathwayi
UPA00223;UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:sdhb
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-030131-8005 sdhb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000034380126 – 280Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialAdd BLAST255

Proteomic databases

PaxDbiA5PL98
PeptideAtlasiA5PL98
PRIDEiA5PL98

Expressioni

Gene expression databases

BgeeiENSDARG00000075768 Expressed in 34 organ(s), highest expression level in muscle tissue

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062263

Structurei

3D structure databases

ProteinModelPortaliA5PL98
SMRiA5PL98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 1292Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST91
Domaini175 – 2054Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
GeneTreeiENSGT00390000013558
HOGENOMiHOG000160590
HOVERGENiHBG005483
InParanoidiA5PL98
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG091G0EKC
PhylomeDBiA5PL98
TreeFamiTF300754

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5PL98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVCFSLSR CCSAVHRPAV TAVRFAQTAA APAAQPRIKK FQIYRWDPDT
60 70 80 90 100
VGDKPRMQTY EIDLNTCGPM VLDALIKIKN EMDSTLTFRR SCREGICGSC
110 120 130 140 150
AMNINGGNTL ACLNKIDTNT SKVTKIYPLP HMYVVKDLVP DMSNFYAQYK
160 170 180 190 200
SIEPYLKKKD ESQQGKQQYL QSVEDRQKLD GLYECILCAC CSTSCPSYWW
210 220 230 240 250
NADKYLGPAV LMQAYRWMID SRDDFTEDRL SKLQDPFSLY RCHTIMNCTR
260 270 280
TCPKGLNPGK AIAEIKKMMV TYKQKDAVAA
Length:280
Mass (Da):31,740
Last modified:July 10, 2007 - v1
Checksum:iA16A68A72849B844
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142799 mRNA Translation: AAI42800.1
RefSeqiNP_001092210.1, NM_001098740.1
UniGeneiDr.75182

Genome annotation databases

EnsembliENSDART00000062264; ENSDARP00000062263; ENSDARG00000075768
GeneIDi562149
KEGGidre:562149

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142799 mRNA Translation: AAI42800.1
RefSeqiNP_001092210.1, NM_001098740.1
UniGeneiDr.75182

3D structure databases

ProteinModelPortaliA5PL98
SMRiA5PL98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062263

Proteomic databases

PaxDbiA5PL98
PeptideAtlasiA5PL98
PRIDEiA5PL98

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000062264; ENSDARP00000062263; ENSDARG00000075768
GeneIDi562149
KEGGidre:562149

Organism-specific databases

CTDi6390
ZFINiZDB-GENE-030131-8005 sdhb

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
GeneTreeiENSGT00390000013558
HOGENOMiHOG000160590
HOVERGENiHBG005483
InParanoidiA5PL98
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG091G0EKC
PhylomeDBiA5PL98
TreeFamiTF300754

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01006

ReactomeiR-DRE-71403 Citric acid cycle (TCA cycle)

Miscellaneous databases

PROiPR:A5PL98

Gene expression databases

BgeeiENSDARG00000075768 Expressed in 34 organ(s), highest expression level in muscle tissue

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDHB_DANRE
AccessioniPrimary (citable) accession number: A5PL98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 10, 2007
Last modified: September 12, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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