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Entry version 47 (07 Apr 2021)
Sequence version 1 (10 Jul 2007)
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Submitted name:

TUSC5 protein



Homo sapiens (Human)
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TUSC5 proteinImported
<p>This subsection of the <a href="">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi


Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei104 – 130HelicalSequence analysisAdd BLAST27
Transmembranei151 – 174HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti


<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases



<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="">IntAct database</a>. It is updated at every <a href="">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

APH1A [Q96BI3]3EBI-11988865,EBI-2606935
APH1B [Q8WW43]3EBI-11988865,EBI-2606497
AQP12B - isoform 2 [A6NM10-2]3EBI-11988865,EBI-17265552
AQP2 [P41181]3EBI-11988865,EBI-12701138
ARL13B [Q3SXY8]3EBI-11988865,EBI-11343438
BCL2L13 [Q9BXK5]3EBI-11988865,EBI-747430
BIK [Q13323]3EBI-11988865,EBI-700794
BSCL2 [J3KQ12]3EBI-11988865,EBI-11532900
C6orf89 - isoform 2 [Q6UWU4-2]3EBI-11988865,EBI-13322241
CCR4 [P51679]3EBI-11988865,EBI-7847466
CD300E [Q496F6]3EBI-11988865,EBI-18010148
CD53 [P19397]3EBI-11988865,EBI-6657396
CD79A [P11912]3EBI-11988865,EBI-7797864
CLDN12 [P56749]3EBI-11988865,EBI-723005
CLDN7 [O95471]3EBI-11988865,EBI-740744
CLDN8 [P56748]3EBI-11988865,EBI-10215641
CLEC10A [Q8IUN9]3EBI-11988865,EBI-2873246
CXCR1 [P25024]3EBI-11988865,EBI-3905522
CXCR2 [P25025]3EBI-11988865,EBI-2835281
DAGLA [Q9Y4D2]3EBI-11988865,EBI-12808806
EBP [Q15125]3EBI-11988865,EBI-3915253
EFNA4 [P52798]3EBI-11988865,EBI-5241592
ELOVL4 [Q9GZR5]3EBI-11988865,EBI-18535450
ERGIC3 [Q9Y282]3EBI-11988865,EBI-781551
FNDC9 [Q8TBE3]3EBI-11988865,EBI-12142257
FUT3 [P21217]3EBI-11988865,EBI-12839380
GJB3 [O75712]3EBI-11988865,EBI-3908586
GPR151 [Q8TDV0]4EBI-11988865,EBI-11955647
GPR42 [O15529]3EBI-11988865,EBI-18076404
GPR61 [Q9BZJ8]3EBI-11988865,EBI-12808020
GPRC5D [Q9NZD1]3EBI-11988865,EBI-13067820
HSF2BP [O75031]3EBI-11988865,EBI-7116203
IFNGR2 [P38484]3EBI-11988865,EBI-3905457
IL3RA [P26951]3EBI-11988865,EBI-1757512
IRF1-AS1 [Q8N8D9]3EBI-11988865,EBI-18100531
KASH5 [Q8N6L0]3EBI-11988865,EBI-749265
KCNC1 [P48547]3EBI-11988865,EBI-12830942
KRT34 [O76011]3EBI-11988865,EBI-1047093
KRTAP5-9 [P26371]3EBI-11988865,EBI-3958099
LAPTM4B [Q86VI4]3EBI-11988865,EBI-3267258
LHFPL5 [Q8TAF8]3EBI-11988865,EBI-2820517
LY6E [Q16553]3EBI-11988865,EBI-18234679
MEOX2 [Q6FHY5]3EBI-11988865,EBI-16439278
MFF - isoform 5 [Q9GZY8-5]3EBI-11988865,EBI-11956541
MFSD14B [Q5SR56]3EBI-11988865,EBI-373355
MRM1 [Q6IN84]3EBI-11988865,EBI-5454865
MRPS18B [Q9Y676]3EBI-11988865,EBI-750085
MTIF3 [Q9H2K0]3EBI-11988865,EBI-3923617
NPFFR2 - isoform 3 [Q9Y5X5-3]3EBI-11988865,EBI-18076879
NPY2R [P49146]3EBI-11988865,EBI-6655721
ODF4 [Q2M2E3]3EBI-11988865,EBI-12382569
OPN1LW [P04000]3EBI-11988865,EBI-13294781
OPRM1 - isoform 10 [P35372-10]3EBI-11988865,EBI-12807478
OR7D4 [Q8NG98]3EBI-11988865,EBI-18164026
OSTC [Q9NRP0]3EBI-11988865,EBI-1044658
PDZK1IP1 [Q13113]3EBI-11988865,EBI-716063
PLEKHB2 [Q96CS7]3EBI-11988865,EBI-373552
RHBDL1 [O75783]3EBI-11988865,EBI-12104986
RHCG [Q9UBD6]3EBI-11988865,EBI-15853497
RTP4 [Q96DX8]3EBI-11988865,EBI-12275482
SCN3B [Q9NY72]3EBI-11988865,EBI-17247926
SDCBP [O00560]3EBI-11988865,EBI-727004
SGPL1 [O95470]3EBI-11988865,EBI-1046170
SLC10A1 [Q14973]3EBI-11988865,EBI-3923031
SLC13A4 [Q9UKG4]3EBI-11988865,EBI-12808018
SLC14A2 [Q15849]3EBI-11988865,EBI-1573290
SLC1A5 [Q15758]3EBI-11988865,EBI-356576
SLC30A2 [Q9BRI3]3EBI-11988865,EBI-8644112
SLC34A2 - isoform 2 [O95436-2]3EBI-11988865,EBI-12811757
SLC35F1 [Q5T1Q4]3EBI-11988865,EBI-13365456
SLC36A1 [Q7Z2H8]3EBI-11988865,EBI-9978258
SLC38A1 [Q9H2H9]3EBI-11988865,EBI-9978441
SLC38A11 [Q08AI6]3EBI-11988865,EBI-12819821
SLC38A6 [Q8IZM9]3EBI-11988865,EBI-13377494
SLC39A1 [Q9NY26]3EBI-11988865,EBI-726491
SLC7A1 [P30825]3EBI-11988865,EBI-4289564
SLC7A14 [Q8TBB6]3EBI-11988865,EBI-5235586
SLCO3A1 - isoform 2 [Q9UIG8-2]3EBI-11988865,EBI-13041931
SPAG4 [Q9NPE6]3EBI-11988865,EBI-10819434
SSMEM1 [Q8WWF3]3EBI-11988865,EBI-17280858
SYNPR [Q8TBG9]3EBI-11988865,EBI-10273251
TAAR9 [Q96RI9]3EBI-11988865,EBI-12908048
TM4SF18 [Q96CE8]3EBI-11988865,EBI-13351685
TMC4 - isoform 3 [Q7Z404-3]3EBI-11988865,EBI-23725088
TMEM179B [Q7Z7N9]3EBI-11988865,EBI-11724423
TMEM237 - isoform 2 [Q96Q45-2]3EBI-11988865,EBI-10982110
TMEM248 [Q9NWD8]3EBI-11988865,EBI-10314986
TMEM45A [Q9NWC5]3EBI-11988865,EBI-10823938
TMEM52B [Q4KMG9]3EBI-11988865,EBI-18178701
TMEM69 [Q5SWH9]3EBI-11988865,EBI-17963363
TMEM71 - isoform 2 [Q6P5X7-2]3EBI-11988865,EBI-12886878
TMEM80 [Q96HE8]6EBI-11988865,EBI-11742770
TMEM9 [Q9P0T7]3EBI-11988865,EBI-723976
TMPPE [Q6ZT21]3EBI-11988865,EBI-11724433
TTYH2 [Q9BSA4]3EBI-11988865,EBI-3959652
WFS1 [O76024]3EBI-11988865,EBI-720609
YIPF6 [Q96EC8]3EBI-11988865,EBI-751210
ZDHHC4 [Q9NPG8]3EBI-11988865,EBI-20009624

Protein-protein interaction databases

Protein interaction database and analysis system

A5PKU2, 98 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi


Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni71 – 93DisorderedSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CD225/Dispanin family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data


Family and domain databases

Integrated resource of protein families, domains and functional sites

View protein in InterPro
IPR007593, CD225/Dispanin_fam

Pfam protein domain database

View protein in Pfam
PF04505, CD225, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="">length</a> and <a href="">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="">Sequence</a> section indicates if the <a href="">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5PKU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
60 70 80 90 100
110 120 130 140 150
160 170
Mass (Da):19,126
Last modified:July 10, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA1FABCD7A1ADCE0

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database


GenBank nucleotide sequence database


DNA Data Bank of Japan; a nucleotide sequence database

Links Updated
BC142615 mRNA Translation: AAI42616.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
Links Updated
BC142615 mRNA Translation: AAI42616.1

3D structure databases

Database of comparative protein structure models


SWISS-MODEL Interactive Workspace

Submit a new modelling project...

Protein-protein interaction databases

IntActiA5PKU2, 98 interactors

Proteomic databases


Phylogenomic databases


Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

TUSC5, human

Family and domain databases

InterProiView protein in InterPro
IPR007593, CD225/Dispanin_fam
PfamiView protein in Pfam
PF04505, CD225, 1 hit

MobiDB: a database of protein disorder and mobility annotations


<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5PKU2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5PKU2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 7, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health

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