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Protein
Submitted name:

TP53 regulating kinase

Gene

TP53RK

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • p53 binding Source: Ensembl
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-6804756 Regulation of TP53 Activity through Phosphorylation

Names & Taxonomyi

Protein namesi
Submitted name:
TP53 regulating kinaseImported
Submitted name:
TP53RK proteinImported
Gene namesi
Name:TP53RKImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:36238 TP53RK

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSBTAG00000027326 Expressed in 10 organ(s), highest expression level in testis

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038979

Structurei

3D structure databases

SMRiA5PK80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 253Protein kinaseInterPro annotationAdd BLAST221

Phylogenomic databases

eggNOGiKOG3087 Eukaryota
COG3642 LUCA
GeneTreeiENSGT00390000012914
HOGENOMiHOG000226425
HOVERGENiHBG028367
KOiK08851
OMAiHKLYMEY
OrthoDBiEOG091G0LKE
TreeFamiTF325502

Family and domain databases

InterProiView protein in InterPro
IPR022495 Bud32
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS
PANTHERiPTHR12209 PTHR12209, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR03724 arch_bud32, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

A5PK80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAADAAASK PNEDLAPAAE ALAAARERNS RFLSGLELVK QGAEARVFRG
60 70 80 90 100
RFQGRAAVVK HRFPKGYRHP TLEARLSRRR TVQEARALLR CRRAGICAPV
110 120 130 140 150
VFFVDYASNC LFMEEIEGSV TVRDYIESTL ETEKSPQSLL DLARTIGQVL
160 170 180 190 200
ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV LIDFGLSFVS ALPEDKGVDL
210 220 230 240 250
YVLEKAFLST HPNTETVFEA FLKSYSAASR KSKPVLKKLD EVRLRGRKRS

MVG
Length:253
Mass (Da):28,172
Last modified:July 10, 2007 - v1
Checksum:i79A83B15C55A7B73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02036794 Genomic DNA No translation available.
BC142392 mRNA Translation: AAI42393.1
RefSeqiNP_001092650.1, NM_001099180.2
UniGeneiBt.7465

Genome annotation databases

EnsembliENSBTAT00000039179; ENSBTAP00000038979; ENSBTAG00000027326
GeneIDi619100
KEGGibta:619100

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02036794 Genomic DNA No translation available.
BC142392 mRNA Translation: AAI42393.1
RefSeqiNP_001092650.1, NM_001099180.2
UniGeneiBt.7465

3D structure databases

SMRiA5PK80
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000038979

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000039179; ENSBTAP00000038979; ENSBTAG00000027326
GeneIDi619100
KEGGibta:619100

Organism-specific databases

CTDi112858
VGNCiVGNC:36238 TP53RK

Phylogenomic databases

eggNOGiKOG3087 Eukaryota
COG3642 LUCA
GeneTreeiENSGT00390000012914
HOGENOMiHOG000226425
HOVERGENiHBG028367
KOiK08851
OMAiHKLYMEY
OrthoDBiEOG091G0LKE
TreeFamiTF325502

Enzyme and pathway databases

ReactomeiR-BTA-6804756 Regulation of TP53 Activity through Phosphorylation

Gene expression databases

BgeeiENSBTAG00000027326 Expressed in 10 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR022495 Bud32
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS
PANTHERiPTHR12209 PTHR12209, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR03724 arch_bud32, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA5PK80_BOVIN
AccessioniPrimary (citable) accession number: A5PK80
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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