Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uridine phosphorylase

Gene

UPP1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes uracil from uridine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine phosphorylase (UPP2), Uridine phosphorylase (UPP1), Uridine phosphorylase (UPP2), Uridine phosphorylase (UPP1)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes uracil from uridine (phosphorylase route), the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00574; UER00633

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylaseUniRule annotation (EC:2.4.2.3UniRule annotation)
Gene namesi
Name:UPP1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Structurei

3D structure databases

ProteinModelPortaliA5PJH9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA5PJH9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 302PNP_UDP_1InterPro annotationAdd BLAST249

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3728 Eukaryota
COG2820 LUCA
HOGENOMiHOG000231747
HOVERGENiHBG047725
KOiK00757

Family and domain databases

InterProiView protein in InterPro
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR010059 Uridine_phosphorylase_euk
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01719 euk_UDPppase, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequencei

Sequence statusi: Complete.

A5PJH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTAAETEK PEDHNDLVQL CNPHIAAMKE DILYHFSLST STHDFPAMFG
60 70 80 90 100
DVKFVCVGGS PSRMKAFIKY VAMELGFAHP GADYPNICEG TDRYAMFKVG
110 120 130 140 150
PVLSVSHGMG VPSIAIMLHE LIKLLYHAHC SGVTLIRIGT SGGIGLEPGS
160 170 180 190 200
VVITRQAVDP CFKPEFEQIV LGKREVRNTD LDEQLVQELA RCSAELGEFP
210 220 230 240 250
TVVGNTMCTL DFYEGQGRLD GALCSYTEKD KQDYLRAAYA AGIRNIEMEA
260 270 280 290 300
SVFAAMCNAC GLRAAVVCVT LLNRLEGDQI SSPHDVLAEY QQRPQRLVGQ

FIKKRLMQA
Length:309
Mass (Da):33,885
Last modified:July 10, 2007 - v1
Checksum:iBA932CE590160C0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142118 mRNA Translation: AAI42119.1
RefSeqiNP_001092446.1, NM_001098976.2
UniGeneiBt.20327

Genome annotation databases

GeneIDi515029
KEGGibta:515029

Similar proteinsi

Entry informationi

Entry nameiA5PJH9_BOVIN
AccessioniPrimary (citable) accession number: A5PJH9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 18, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health