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UniProtKB - A5LGM7 (TRET1_POLVA)
Protein
Facilitated trehalose transporter Tret1
Gene
Tret1
Organism
Polypedilum vanderplanki (Sleeping chironomid midge)
Status
Functioni
High-capacity facilitative transporter for trehalose, required to induce anhydrobiosis. Anhydrobiotic larvae can survive almost complete dehydration. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
2 PublicationsKineticsi
- KM=114.5 mM for trehalose2 Publications
pH dependencei
Wide extracellular pH range, between 4.0 and 9.0.2 Publications
GO - Molecular functioni
- sugar transmembrane transporter activity Source: InterPro
- trehalose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- trehalose transport Source: UniProtKB
Keywordsi
Biological process | Stress response, Sugar transport, Transport |
Protein family/group databases
TCDBi | 2.A.1.1.129, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Facilitated trehalose transporter Tret11 PublicationImportedShort name: PvTret11 Publication |
Gene namesi | Name:Tret1Imported |
Organismi | Polypedilum vanderplanki (Sleeping chironomid midge) |
Taxonomic identifieri | 319348 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Chironomoidea › Chironomidae › Chironominae › Polypedilum › Polypedilum |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Sequence analysis2 Publications
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 60 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 61 – 87 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 88 – 108 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 109 – 120 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 121 – 141 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 142 – 145 | ExtracellularSequence analysis | 4 | |
Transmembranei | 146 – 166 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 167 – 171 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 172 – 192 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 193 – 199 | ExtracellularSequence analysis | 7 | |
Transmembranei | 200 – 220 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 283 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 284 – 304 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 305 – 320 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 321 – 341 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 342 – 347 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 348 – 368 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 369 – 387 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 388 – 408 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 409 – 424 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 425 – 445 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 448 | ExtracellularSequence analysis | 3 | |
Transmembranei | 449 – 469 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 470 – 504 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395551 | 1 – 504 | Facilitated trehalose transporter Tret1Add BLAST | 504 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinExpressioni
Tissue specificityi
Highest expression in the fat body. Not expressed in other tissues including the midgut, muscle, and integuments after 24 h of dehydration.2 Publications
Inductioni
By hypersalinity.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily. [View classification]Sequence analysis1 Publication
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd17358, MFS_GLUT6_8_Class3_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044775, MFS_ERD6/Tret1-like IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A5LGM7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELNNKEDSP RHTVPFVRQI TEDGKAKLEI YRPTTNPIYI YTQILAAIAV
60 70 80 90 100
SMGSMVVGFA SAYTSPALVS MQNTTITSFK VTEQEASWVG GIMPLAGLAG
110 120 130 140 150
GIAGGPFIEY LGRKNTILAT AVPFIVAWLL IAFANSIWMV LAGRALSGFC
160 170 180 190 200
VGIASLSLPV YLGETVQPEV RGTLGLLPTA FGNIGILICF VAGKYVNWSG
210 220 230 240 250
LAFIGSILPI PFMVLTLLIP ETPRWFVTRG REERARKALQ WLRGKKADVE
260 270 280 290 300
PELKGIVKSH CEAERHASQN AIFDLMKRSN LKPLLIALGL MFFQQLSGIN
310 320 330 340 350
AVIFYTVSIF KDAGSTIDEN LCTIIVGVVN FGATFFATVL IDRLGRKILL
360 370 380 390 400
YISEVAMVIT LLTLGTFFYY KNSGNDVSNI GWLPLASFVI YVIGFSSGVG
410 420 430 440 450
PIPWLMLGEI LPGKIRGSAA SVATGFNWTC TFIVTKTFAD IVAAIGNHGA
460 470 480 490 500
FWFFGVICLI GLFFVIFFVP ETQGKSLEEI ERKMMGRVRR MSSVANMKPL
SFNM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB272983 mRNA Translation: BAF63703.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB272983 mRNA Translation: BAF63703.1 |
3D structure databases
SMRi | A5LGM7 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 2.A.1.1.129, the major facilitator superfamily (mfs) |
Family and domain databases
CDDi | cd17358, MFS_GLUT6_8_Class3_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044775, MFS_ERD6/Tret1-like IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRET1_POLVA | |
Accessioni | A5LGM7Primary (citable) accession number: A5LGM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 13, 2010 |
Last sequence update: | July 10, 2007 | |
Last modified: | February 23, 2022 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |