Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 109 (29 Sep 2021)
Sequence version 1 (26 Jun 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Paired amphipathic helix protein sin-3

Gene

sin-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status (PubMed:21909284).

Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC) (PubMed:17506990).

1 Publication2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired amphipathic helix protein sin-3By similarity
Alternative name(s):
Histone deacetylase complex subunit sin-3By similarity
Transcriptional corepressor sin-3By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sin-3Imported
Synonyms:pqn-281 Publication
ORF Names:F02E9.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F02E9.4a ; CE33046 ; WBGene00004117 ; sin-3
F02E9.4b ; CE40934 ; WBGene00004117 ; sin-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Uncoordinated movement, protruding vulva and ray fusion defects in the male tail (PubMed:17506990). RNAi-mediated knockdown results in sterility (PubMed:16710447). RNAi-mediated knockdown in a him-8 mutant background results in no deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (PubMed:21909284).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004378711 – 1507Paired amphipathic helix protein sin-3CuratedAdd BLAST1507

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A5JYW9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A5JYW9

PeptideAtlas

More...
PeptideAtlasi
A5JYW9

PRoteomics IDEntifications database

More...
PRIDEi
A5JYW9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A5JYW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all ray structural cells including ray 6, 7, 8 and 9 of the male tail. Also expressed in the inner labial neurons, socket cells, the cephalic neurons in the head and the ventral nerve cord.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from the L1 stage of larval development to adulthood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004117, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SIN3S complex, which contains at least sin-3, hda-1, athp-1 and mrg-1 (PubMed:31602465).

Interacts with ztf-11; the interaction is weak (PubMed:31386623).

Interacts with cfp-1 (PubMed:31602465).

2 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A5JYW9, 17 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F02E9.4b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A5JYW9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini282 – 352PAHPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni228 – 286DisorderedSequence analysisAdd BLAST59
Regioni397 – 450DisorderedSequence analysisAdd BLAST54
Regioni543 – 569DisorderedSequence analysisAdd BLAST27
Regioni1349 – 1434DisorderedSequence analysisAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 26Polar residuesSequence analysisAdd BLAST15
Compositional biasi402 – 426Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi427 – 445Acidic residuesSequence analysisAdd BLAST19
Compositional biasi1353 – 1378Acidic residuesSequence analysisAdd BLAST26
Compositional biasi1379 – 1393Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1394 – 1417Acidic residuesSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4204, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171042

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_242902_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A5JYW9

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCEEVIK

Database of Orthologous Groups

More...
OrthoDBi
253485at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A5JYW9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1160.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013194, HDAC_interact_dom
IPR003822, PAH
IPR036600, PAH_sf
IPR039774, Sin3-like
IPR031693, Sin3_C

The PANTHER Classification System

More...
PANTHERi
PTHR12346, PTHR12346, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02671, PAH, 1 hit
PF08295, Sin3_corepress, 1 hit
PF16879, Sin3a_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00761, HDAC_interact, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47762, SSF47762, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51477, PAH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform bImported (identifier: A5JYW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYNPPPGGGG GNNGGDQSQQ QPTNNATLFL LQMIQQSQHQ QQHQNQQQQQ
60 70 80 90 100
LELQIRDQER ILIEQQRMQH QQQQNQLLQG LNQFPFNPLG LFQVQAAVQA
110 120 130 140 150
AQAQFAQNAQ GSPIPFHIGS PLQPSHSPAA SALQQQYLLP SHSPAITPFA
160 170 180 190 200
RNSEAARNIE QFIAQEEAAN VPRANSQQQS PLIRPIPQQQ ALNIQNLTST
210 220 230 240 250
QQAQQILAHH RQVPVQQVQH QQHIPTPPLA LPIAQQGPIS NEVPSVPPVV
260 270 280 290 300
PATSAGCPQR EPRQQQGGRR QNRPGRRKKP EGPPRVDEAL AYLRVIKSTF
310 320 330 340 350
SSDVPVYHRF LEIMKDFRAQ RIETPDVIEQ VAELLYDSPE LVLGFNTFLP
360 370 380 390 400
TGYRITLTPD RKYVFSSPQM QPRVLLSPDE RRARAIEAGA QAVGAIELGS
410 420 430 440 450
QEGISKDEDR TIEDEDMDKS KEKDDVDGID DEDDEESGIE DKNNEEMMEE
460 470 480 490 500
DNHLIEEIIC DDRKKDDCED SQQEIEMSSE LAAHTLNIIE LLKKSFLARP
510 520 530 540 550
TKLVDFMTFI DFFMSDQQYK KDMEKLRKDD EDDEIEENEK IEVDDVPGPS
560 570 580 590 600
NAPQEIKKPD DIEKKDSSKN LQIEESCSDY LVSMLANCCI GEPDLLAATI
610 620 630 640 650
DFLPYLGKLL VNGSDAIALK IKTILHFSAT NDRNDIPPVN RVNPSDVDMD
660 670 680 690 700
LVKQMEKCKM GTKKNEKLKL KVAGQGDEGA TVELMILKKS YRILYERLKS
710 720 730 740 750
RTTPNQLSHL MVLINAYANL DITREQLISE LPKIMGTSGS DLEMIILQLL
760 770 780 790 800
GAEKEPKNRP ENDMDAVMRK DLPAIQPKRG LRDQKMLQQV KNVEAATVCT
810 820 830 840 850
LGPSYRFMKD TKATDCSGRV ELDDDLKGVL NDTWTSIPSW SSEDTGSQAI
860 870 880 890 900
KKSNLEEFHF KTEDERYELD IIVDSNRTVI EQLSKTLRDY EAMSDEDKKS
910 920 930 940 950
FKLDKWLNAS SRSTTIRVLA KVFTNSAQDF IDAAQKNPLV GLRRILESLK
960 970 980 990 1000
EKDLLWSRFQ QDTNRTWRDA LDKQMSAATT ILNNQHKNYD QKAFKSKPLV
1010 1020 1030 1040 1050
NQIEQICEER RKNNSTDTSP HLILEYTPER KVYRDVNDVT GHFFHDLSGT
1060 1070 1080 1090 1100
KCDRDRTKIV LFSYRILMEW LCQEGQQVQI DLDNGEIFKF QGDLNEDENL
1110 1120 1130 1140 1150
MTLLNMDGRR ICGDRVVPVS TSLESNESSI DHFSENLHQK RTRRTFYGDD
1160 1170 1180 1190 1200
SVYMIIRYHH MIQERFAKIL STQAIYAQEH FDNQKKNKRW EDGIGADMHG
1210 1220 1230 1240 1250
RKALQENIKQ RRAAVNDIRN VRSCPSSSYE TTLRELKQLG NAQMDIVAFE
1260 1270 1280 1290 1300
EAVKNLFPGD IVLFNNIDKL FSSLAKNIHH ATCAEERENP IKLYLKYRQR
1310 1320 1330 1340 1350
IMNAERDEDM ESVIQEYGQT AEEVLRGKNT YRFEFVEEQN KPFIKIWVIP
1360 1370 1380 1390 1400
REEKDDDDDD DEEGNEGGKD EDNVKDEDDG GDGEGRDGPD DDQPPPSNDD
1410 1420 1430 1440 1450
GDDEEDEDDE EDGPSGADEP ESTSGSGNVP MDHLNIGENF LWSPPEEKVC
1460 1470 1480 1490 1500
TGKMTTNEKE QRNSVDYMKV TTTPRLRIHK RMLKEHKGCN VELMTGFQQL

SAIVPLM
Length:1,507
Mass (Da):171,747
Last modified:June 26, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB1793888B158CB0
GO
Isoform aImported (identifier: A5JYW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1063-1064: Missing.

Show »
Length:1,505
Mass (Da):171,497
Checksum:iC3273743FC0EFD51
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0585731063 – 1064Missing in isoform a. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB04052.2
BX284601 Genomic DNA Translation: CAN86581.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20513

NCBI Reference Sequences

More...
RefSeqi
NP_001122442.1, NM_001128970.2 [A5JYW9-1]
NP_492284.2, NM_059883.5 [A5JYW9-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F02E9.4a.1; F02E9.4a.1; WBGene00004117 [A5JYW9-2]
F02E9.4b.1; F02E9.4b.1; WBGene00004117 [A5JYW9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172628

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F02E9.4

UCSC genome browser

More...
UCSCi
F02E9.4b, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB04052.2
BX284601 Genomic DNA Translation: CAN86581.1
PIRiT20513
RefSeqiNP_001122442.1, NM_001128970.2 [A5JYW9-1]
NP_492284.2, NM_059883.5 [A5JYW9-2]

3D structure databases

SMRiA5JYW9
ModBaseiSearch...

Protein-protein interaction databases

IntActiA5JYW9, 17 interactors
STRINGi6239.F02E9.4b

PTM databases

iPTMnetiA5JYW9

Proteomic databases

EPDiA5JYW9
PaxDbiA5JYW9
PeptideAtlasiA5JYW9
PRIDEiA5JYW9

Genome annotation databases

EnsemblMetazoaiF02E9.4a.1; F02E9.4a.1; WBGene00004117 [A5JYW9-2]
F02E9.4b.1; F02E9.4b.1; WBGene00004117 [A5JYW9-1]
GeneIDi172628
KEGGicel:CELE_F02E9.4
UCSCiF02E9.4b, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172628
WormBaseiF02E9.4a ; CE33046 ; WBGene00004117 ; sin-3
F02E9.4b ; CE40934 ; WBGene00004117 ; sin-3

Phylogenomic databases

eggNOGiKOG4204, Eukaryota
GeneTreeiENSGT00940000171042
HOGENOMiCLU_242902_0_0_1
InParanoidiA5JYW9
OMAiMCEEVIK
OrthoDBi253485at2759
PhylomeDBiA5JYW9

Enzyme and pathway databases

ReactomeiR-CEL-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A5JYW9

Gene expression databases

BgeeiWBGene00004117, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

Gene3Di1.20.1160.11, 1 hit
InterProiView protein in InterPro
IPR013194, HDAC_interact_dom
IPR003822, PAH
IPR036600, PAH_sf
IPR039774, Sin3-like
IPR031693, Sin3_C
PANTHERiPTHR12346, PTHR12346, 1 hit
PfamiView protein in Pfam
PF02671, PAH, 1 hit
PF08295, Sin3_corepress, 1 hit
PF16879, Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761, HDAC_interact, 1 hit
SUPFAMiSSF47762, SSF47762, 1 hit
PROSITEiView protein in PROSITE
PS51477, PAH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIN3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5JYW9
Secondary accession number(s): O01319
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: June 26, 2007
Last modified: September 29, 2021
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again