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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:SaurJH9_2102
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000826731 – 159Serine-protein kinase RsbWAdd BLAST159

Structurei

3D structure databases

ProteinModelPortaliA5IUL1
SMRiA5IUL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000269932
KOiK04757
OMAiKMGFSYE

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00638 Anti_sigma_B, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR010193 RsbW
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01924 rsbW_low_gc, 1 hit

Sequencei

Sequence statusi: Complete.

A5IUL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSKEDFIEM RVPASAEYVS LIRLTLSGVF SRAGATYDDI EDAKIAVSEA
60 70 80 90 100
VTNAVKHAYK ENNNVGIINI YFEILEDKIK IVISDKGDSF DYETTKSKIG
110 120 130 140 150
PYDKDENIDF LREGGLGLFL IESLMDEVTV YKESGVTISM TKYIKKEQVR

NNGERVEIS
Length:159
Mass (Da):17,921
Last modified:June 26, 2007 - v1
Checksum:i57FA8EB8C1F9902B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA Translation: ABQ49884.1

Genome annotation databases

EnsemblBacteriaiABQ49884; ABQ49884; SaurJH9_2102
KEGGisaj:SaurJH9_2102

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA Translation: ABQ49884.1

3D structure databases

ProteinModelPortaliA5IUL1
SMRiA5IUL1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ49884; ABQ49884; SaurJH9_2102
KEGGisaj:SaurJH9_2102

Phylogenomic databases

HOGENOMiHOG000269932
KOiK04757
OMAiKMGFSYE

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00638 Anti_sigma_B, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR010193 RsbW
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01924 rsbW_low_gc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSBW_STAA9
AccessioniPrimary (citable) accession number: A5IUL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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