UniProtKB - A5I6W0 (CLPX_CLOBH)
Protein
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene
clpX
Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Functioni
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 12 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 15 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 34 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 37 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 116 – 123 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: GO_Central
- ATP-dependent peptidase activity Source: GO_Central
- protein dimerization activity Source: InterPro
- unfolded protein binding Source: UniProtKB-UniRule
- zinc ion binding Source: InterPro
GO - Biological processi
- cell division Source: GO_Central
- protein catabolic process Source: GO_Central
- protein folding Source: UniProtKB-UniRule
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BioCyci | CBOT441771:G1G97-3035-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation |
Gene namesi | Name:clpXUniRule annotation Ordered Locus Names:CBO3230, CLC_3141 |
Organismi | Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) |
Taxonomic identifieri | 441771 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000058334 | 1 – 429 | ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST | 429 |
Proteomic databases
PRIDEi | A5I6W0 |
Interactioni
Subunit structurei
Component of the ClpX-ClpP complex.
Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
UniRule annotationGO - Molecular functioni
- protein dimerization activity Source: InterPro
- unfolded protein binding Source: UniProtKB-UniRule
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 53 | ClpX-type ZBPROSITE-ProRule annotationAdd BLAST | 53 |
Sequence similaritiesi
Belongs to the ClpX chaperone family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000010093 |
KOi | K03544 |
OMAi | HYKRVQA |
Family and domain databases
Gene3Di | 3.30.50.30, 1 hit |
HAMAPi | MF_00175 ClpX, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR019489 Clp_ATPase_C IPR004487 Clp_protease_ATP-bd_su_ClpX IPR027417 P-loop_NTPase IPR010603 Znf_CppX_C4 IPR038366 Znf_CppX_C4_sf |
PANTHERi | PTHR11262 PTHR11262, 2 hits |
Pfami | View protein in Pfam PF07724 AAA_2, 1 hit PF10431 ClpB_D2-small, 1 hit PF06689 zf-C4_ClpX, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit SM01086 ClpB_D2-small, 1 hit SM00994 zf-C4_ClpX, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00382 clpX, 1 hit |
PROSITEi | View protein in PROSITE PS51902 CLPX_ZB, 1 hit |
i Sequence
Sequence statusi: Complete.
A5I6W0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKLDEKKQL KCSFCGKTQD QVRRLIAGPG VYICDECIEL CSEIINDEFE
60 70 80 90 100
DDIQVDLTSL PKPTEIKTYL DQYVIGQEDA KKSLSVAVYN HYKRINSNTN
110 120 130 140 150
NDDVELQKSN ILLLGPTGSG KTLLAQTLAK FLNVPFAIAD ATTLTEAGYV
160 170 180 190 200
GEDVENILLK LIQNADYDIE KAEKGIVYID EIDKIARKSE NPSITRDVSG
210 220 230 240 250
EGVQQALLKI LEGTVAAVPP QGGRKHPHQE FIQINTTNIL FICGGAFDGV
260 270 280 290 300
DKIIERRTRT SSLGFGAEIQ SKKEKDLGKL LKDIMPGDLL KFGLIPEFIG
310 320 330 340 350
RLPIVVTLDK LDREALIKIL TEPKNALVKQ YKKLFELDDV ELEFNQEALK
360 370 380 390 400
EIADEAINRN TGARGLRAII EDMMREIMFD IPSQENIGKV IVNEDCIKTK
410 420
KPELIEAEGG KRLPIKPKKG KKRKDSETA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000727 Genomic DNA Translation: ABS36889.1 AM412317 Genomic DNA Translation: CAL84792.1 |
RefSeqi | WP_003357457.1, NC_009698.1 YP_001255720.1, NC_009495.1 YP_001388960.1, NC_009698.1 |
Genome annotation databases
EnsemblBacteriai | ABS36889; ABS36889; CLC_3141 |
GeneIDi | 5187485 5400033 |
KEGGi | cbh:CLC_3141 cbo:CBO3230 |
PATRICi | fig|413999.7.peg.3209 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000727 Genomic DNA Translation: ABS36889.1 AM412317 Genomic DNA Translation: CAL84792.1 |
RefSeqi | WP_003357457.1, NC_009698.1 YP_001255720.1, NC_009495.1 YP_001388960.1, NC_009698.1 |
3D structure databases
SMRi | A5I6W0 |
ModBasei | Search... |
Proteomic databases
PRIDEi | A5I6W0 |
Genome annotation databases
EnsemblBacteriai | ABS36889; ABS36889; CLC_3141 |
GeneIDi | 5187485 5400033 |
KEGGi | cbh:CLC_3141 cbo:CBO3230 |
PATRICi | fig|413999.7.peg.3209 |
Phylogenomic databases
HOGENOMi | HOG000010093 |
KOi | K03544 |
OMAi | HYKRVQA |
Enzyme and pathway databases
BioCyci | CBOT441771:G1G97-3035-MONOMER |
Miscellaneous databases
PROi | PR:A5I6W0 |
Family and domain databases
Gene3Di | 3.30.50.30, 1 hit |
HAMAPi | MF_00175 ClpX, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR019489 Clp_ATPase_C IPR004487 Clp_protease_ATP-bd_su_ClpX IPR027417 P-loop_NTPase IPR010603 Znf_CppX_C4 IPR038366 Znf_CppX_C4_sf |
PANTHERi | PTHR11262 PTHR11262, 2 hits |
Pfami | View protein in Pfam PF07724 AAA_2, 1 hit PF10431 ClpB_D2-small, 1 hit PF06689 zf-C4_ClpX, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit SM01086 ClpB_D2-small, 1 hit SM00994 zf-C4_ClpX, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00382 clpX, 1 hit |
PROSITEi | View protein in PROSITE PS51902 CLPX_ZB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLPX_CLOBH | |
Accessioni | A5I6W0Primary (citable) accession number: A5I6W0 Secondary accession number(s): A7G845 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | June 26, 2007 | |
Last modified: | October 16, 2019 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families