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Protein

Argininosuccinate lyase

Gene

argH

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciCBOT441771:G1G97-2448-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:CBO2669, CLC_2543
OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifieri441771 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001986 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000004681 – 440Argininosuccinate lyaseAdd BLAST440

Structurei

3D structure databases

ProteinModelPortaliA5I5A3
SMRiA5I5A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A5I5A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWGGRFKE EESKLMEDFN SSLSFDKKLY YEDIKGSIAH VKMLTNQNII
60 70 80 90 100
KEEEKEKILL GLEEILKEID EGILKIEGDY EDIHSFVEIN LINKIGNVGK
110 120 130 140 150
KLHTGRSRND QVALDMKLYA KKSTEEVIEC LKELMDSLIK VGNENNYIMP
160 170 180 190 200
GYTHLQRAQV VTFRYHLLAY FEMFKRDEKR LENALEILNE SPLGSGALAG
210 220 230 240 250
STYNIDKEYT AKLLGFRKPV DNFLDGVSDR DYIIELISKF SIIMMHLSRL
260 270 280 290 300
SEELILWSSS EFRFIQIGDA YSTGSSIMPQ KKNPDGAELI RGKIGRVYGD
310 320 330 340 350
LISILTVMKS LPLAYNKDMQ EDKEPFFDAK DTVISCLKVM EGIISTLKVN
360 370 380 390 400
KENLMKSVKK GFLNATEAAD YLVNKGMAFR DAHKVIGEVV IYCEDKNSAI
410 420 430 440
EDLSLEELKQ FSDLFCEDIY EFIDYKNSIN KGIKKEMGYF
Length:440
Mass (Da):50,482
Last modified:June 26, 2007 - v1
Checksum:i10C3B618D629C920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000727 Genomic DNA Translation: ABS38692.1
AM412317 Genomic DNA Translation: CAL84230.1
RefSeqiWP_011986965.1, NC_009698.1
YP_001255168.1, NC_009495.1
YP_001388381.1, NC_009698.1

Genome annotation databases

EnsemblBacteriaiABS38692; ABS38692; CLC_2543
GeneIDi5186924
5400970
KEGGicbh:CLC_2543
cbo:CBO2669
PATRICifig|413999.7.peg.2652

Similar proteinsi

Entry informationi

Entry nameiARLY_CLOBH
AccessioniPrimary (citable) accession number: A5I5A3
Secondary accession number(s): A7G6G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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