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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362Required for activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 176ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT441771:G1G97-179-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:CBO0154, CLC_0202
OrganismiClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Taxonomic identifieri441771 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001986 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000550631 – 504ATP synthase subunit alphaAdd BLAST504

Proteomic databases

PRIDEiA5HY50

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA5HY50
SMRiA5HY50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000130111
KOiK02111
OMAiGNAQIKS

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088 F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

A5HY50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIKPEEITS IIRQQIENFN TNIETIDSGT IIQIGDGIAR VYGLEDCMEG
60 70 80 90 100
ELIEFPNDVY GMALNLEQDN VGCVLLGSEE GIKEGNVVKR TKKVVEVPVG
110 120 130 140 150
EALVGRVVNS LGMPIDGKGP VLTTETRDVE VPAPGVIDRQ SVKEPLQTGI
160 170 180 190 200
KAIDSMIPIG KGQRELIIGD RQTGKTAIAM DTILNQKGKD VICIYVAIGQ
210 220 230 240 250
KQSTVAHIVN DLTKMGAMDY TIVVSSTASD SAPLQYLAPY AGCSMGEYFM
260 270 280 290 300
HKGKDVLIVY DDLSKHAVAY RTMSLLLRRP PGREAYPGDV FYLHSRLLER
310 320 330 340 350
SARLSEKLGG GSLTALPIVE TLAGDVTAYI PTNVISITDG QIFLESELFN
360 370 380 390 400
AGQRPAVNAG ISVSRVGGNA QIKAMKQVAG TLRLELAQYR ELAAFSQFGS
410 420 430 440 450
DLDKESVKRL EKGKRLVEIL KQPQYSPMPV EKEIIILYAA VSNHLIDIPV
460 470 480 490 500
NKIKEFEKEL FNYIDTHYRD IGKDILEHKQ LTDELKSKLD KAINDFKNVF

LSEI
Length:504
Mass (Da):55,426
Last modified:June 26, 2007 - v1
Checksum:i59A0BBF43FB3F113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000727 Genomic DNA Translation: ABS39106.1
AM412317 Genomic DNA Translation: CAL81709.1
RefSeqiWP_003356056.1, NC_009698.1
YP_001252701.1, NC_009495.1
YP_001386113.1, NC_009698.1

Genome annotation databases

EnsemblBacteriaiABS39106; ABS39106; CLC_0202
GeneIDi5184409
5399333
KEGGicbh:CLC_0202
cbo:CBO0154
PATRICifig|413999.7.peg.153

Similar proteinsi

Entry informationi

Entry nameiATPA_CLOBH
AccessioniPrimary (citable) accession number: A5HY50
Secondary accession number(s): A7G070
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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