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Protein

Sister chromatid cohesion protein SCC2

Gene

SCC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential protein required for cell fate determination during embryogenesis (PubMed:19228337, PubMed:15266054, PubMed:28137757). Involved in sister chromatid cohesion during meiosis and mitosis (PubMed:19228337, PubMed:19533160). Forms a complex with SCC4, which is required for the association of the cohesin complex with chromosomes (PubMed:28137757). Plays a structural role in chromatin, especially in centromere organization, chromosomal axis formation, and distribution of the cohesin subunit SCC3 on chromosomes (PubMed:19228337).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri699 – 748PHD-typePROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Meiosis, Mitosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-ATH-2470946 Cohesin Loading onto Chromatin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion protein SCC21 Publication
Alternative name(s):
Protein EMBRYO DEFECTIVE 27731 Publication
Protein SISTER-CHROMATID COHESION 21 Publication
Short name:
AtSCC21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCC21 Publication
Synonyms:EMB27731 Publication
Ordered Locus Names:At5g15540Imported
ORF Names:T20K14.150Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT5G15540

The Arabidopsis Information Resource

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TAIRi
locus:2180942 AT5G15540

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defective embryo arrested at preglobular/early globular stage with the formation of giant endosperm nuclei (PubMed:19228337, PubMed:15266054, PubMed:28137757). Suspensor overproliferation phenotype preceded by ectopic auxin maxima distribution (PubMed:28137757). Reduced sister chromatid cohesion (PubMed:19533160). In conditional RNAi plants, sterility, arising from several defects in meiotic chromosome organization (e.g. failure of homologous pairing, loss of sister-chromatid cohesion, mixed segregation of chromosomes and chromosome fragmentation) and leading to shrunken and inviable pollen grains, and degeneration of the embryo sac. In the meiocytes, aberrant distribution of the cohesin subunit SCC3 on chromosomes, and defects in chromosomal axis formation (PubMed:19228337).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004406501 – 1846Sister chromatid cohesion protein SCC2Add BLAST1846

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A5HEI1

PRoteomics IDEntifications database

More...
PRIDEi
A5HEI1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A5HEI1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in leaves, inflorescence and siliques.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected throughout the embryo, covering all stages of development from pre-globular to torpedo stages. Also detected in the suspensor and endosperm.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A5HEI1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SCC4 to form the cohesin loading complex.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G15540.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A5HEI1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati243 – 282HEAT 1Sequence analysisAdd BLAST40
Repeati298 – 335HEAT 2Sequence analysisAdd BLAST38
Repeati438 – 460HEAT 3Sequence analysisAdd BLAST23
Repeati461 – 499HEAT 4Sequence analysisAdd BLAST39
Repeati532 – 572HEAT 5Sequence analysisAdd BLAST41
Repeati613 – 631HEAT 6Sequence analysisAdd BLAST19
Repeati632 – 672HEAT 7Sequence analysisAdd BLAST41
Repeati781 – 818HEAT 8Sequence analysisAdd BLAST38
Repeati869 – 906HEAT 9Sequence analysisAdd BLAST38
Repeati945 – 982HEAT 10Sequence analysisAdd BLAST38
Repeati984 – 1021HEAT 11Sequence analysisAdd BLAST38
Repeati1053 – 1097HEAT 12Sequence analysisAdd BLAST45
Repeati1113 – 1152HEAT 13Sequence analysisAdd BLAST40
Repeati1174 – 1213HEAT 14Sequence analysisAdd BLAST40
Repeati1227 – 1267HEAT 15Sequence analysisAdd BLAST41
Repeati1277 – 1314HEAT 16Sequence analysisAdd BLAST38
Repeati1427 – 1464HEAT 17Sequence analysisAdd BLAST38
Repeati1475 – 1512HEAT 18Sequence analysisAdd BLAST38
Repeati1533 – 1575HEAT 19Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1813 – 1821Asp-richPROSITE-ProRule annotation9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCC2/Nipped-B family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri699 – 748PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1020 Eukaryota
ENOG410XP32 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000276888

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A5HEI1

KEGG Orthology (KO)

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KOi
K06672

Identification of Orthologs from Complete Genome Data

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OMAi
KQGLAHP

Database of Orthologous Groups

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OrthoDBi
EOG093600IF

Database for complete collections of gene phylogenies

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PhylomeDBi
A5HEI1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026003 Cohesin_HEAT
IPR024986 Nipped-B_C
IPR033031 SCC2/Nipped-B
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR21704 PTHR21704, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12765 Cohesin_HEAT, 1 hit
PF12830 Nipped-B_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A5HEI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNPSSSGLG SSSGLTHFGI GLANTVQSEV TPYLPLPSLP IFCGAAEPGE
60 70 80 90 100
FKLFDEVGQG SGYRSLDRSE ILAQSSRIAN MLHETDVSYL DLRNEARAPD
110 120 130 140 150
CNSGEHFQLY DLVLRCNPGA FEYVTPGPTC DPLFTNEGPQ KIISEPSVPV
160 170 180 190 200
KMQRQTDTHL ARSIEPEPVK RVLRPNHVED HSWQHETLTN QSPKDVTAYD
210 220 230 240 250
SRPETITMNE LSASKKPKGK KKRKDDLSSV QPDPSVLQES IVQNFCEMLE
260 270 280 290 300
DFCGRAEVPG DDRDEAEWSS VPVDEVRVLI NELMTIRSKM LLHMVPVDIL
310 320 330 340 350
SRLLRTLDHQ IHRAEGLSIY SEHSDSDSVL LVLGALESIH ASLAVMANSD
360 370 380 390 400
MPKQLYKEEI IERILEFSRH QMMAVMSAYD PSYRTGSKPA ENLAFEGDDD
410 420 430 440 450
DDNPDHDMGS ASKRRRIVKN SKVKKASVNR ISGAVNTALQ KLCTILGLLK
460 470 480 490 500
DLLLVERLSD SCILQLLKTS ITTFLVENIQ ILQLKAISLI GGIYNSYSQH
510 520 530 540 550
RTYVIDEISQ LLWKLPSSKR ALRAYLLPDE EQRQIQMVTA LLIQLVHNST
560 570 580 590 600
SLPETSRQAA SGNSILETSV DVGYLTKCHE AATETCCLFW TRVLERFTSF
610 620 630 640 650
KGQDASEIKL IIENLVMDLL TALNLPEYPS VSPILEVLCV ILLHNAGLKS
660 670 680 690 700
KDVSARIMAI ELLGTIAARL KRDAVLCSKD RFWTLLESDS EISVDQVCTK
710 720 730 740 750
DCTFCLGKRA GNLLVCQICQ RRFHGDCLGL KELDISSRNW HCPLCVCKRQ
760 770 780 790 800
LLVLQSYCKT DTKGTGKLES EESIENPSMI TKTEVVQQML LNYLQDVGSA
810 820 830 840 850
DDVHTFICWF YLCLWYKDVP KSQNKFKYYI ARLKAKSIIR NSGATTSFLT
860 870 880 890 900
RDAIKQITLA LGMNSSFSRG FDKILNMLLA SLRENAPNIR AKALRAVSII
910 920 930 940 950
VEADPEVLCD KRVQLAVEGR FCDSAISVRE AALELVGRHI ASHPDVGIKY
960 970 980 990 1000
FEKVAERIKD TGVSVRKRAI KIIRDMCTSN PNFSEFTSAC AEILSRISDD
1010 1020 1030 1040 1050
ESSVQDLVCK TFYEFWFEEP PGHHTQFASD ASSIPLELEK KTKQMVGLLS
1060 1070 1080 1090 1100
RTPNQQLLVT IIKRALALDF FPQAAKAAGI NPVALASVRR RCELMCKCLL
1110 1120 1130 1140 1150
EKILQVEEMS REEGEVQVLP YVLVLHAFCL VDPGLCTPAS DPTKFVITLQ
1160 1170 1180 1190 1200
PYLKSQADSR TGAQLLESII FIIDSVLPLI RKLPLSVTED LEQDLKHMIV
1210 1220 1230 1240 1250
RHSFLTVVHA CVRCLCSVSK LAGKGVSIVE HLLQFFFKRL EAQGSDNTQI
1260 1270 1280 1290 1300
AGRSLFCLGL LIRHGNSLIS TSGGKNFNLS GCLNLFKRHL RTEDIALKVR
1310 1320 1330 1340 1350
SLQALGFILI ARPEYMLEED IGKIIETTLA DEANGRMKMQ ALQNMYEYLL
1360 1370 1380 1390 1400
DAEKQLGSEK ASDNTVNSVE QGGHNVPVAA GAGDTNICGG IVQLFWDKIL
1410 1420 1430 1440 1450
GRCLDFDDQI RQTSLKIVEV VLRQGLVHPI TCVPYLIALE TDPQEANQKL
1460 1470 1480 1490 1500
AHHLLMNMHE KYPAFFESRL GDGLQMSFIF MQSISQVTSE PNQSLQQKGS
1510 1520 1530 1540 1550
TNMLGKNDHA SSTLTQARLG VSRIYKLIRG NRVSRNKFMT SIVRKFDNPT
1560 1570 1580 1590 1600
WNGSVISFLK YCTETLALLP FTSPDEPLYL VYSINRVMQI RAGAVESNLK
1610 1620 1630 1640 1650
ALLHKDSAKT QHGNGAYQQD PIPGHMNMMD LNTRIQEEPR HWNSYGHATL
1660 1670 1680 1690 1700
IDLNGSVYQD SRDQFTSYQV HNGKADVHKM TSSDPPELST DDLQKIQVDC
1710 1720 1730 1740 1750
LAAIAIQLLL KLKRYLKVTY SLNDDRCQAY SPTEPLKPGD PLSRQSVAFD
1760 1770 1780 1790 1800
LSETRTDLPS TYQDLVQRYQ EFKNAMREDT VDFTIYSTNV KRKRPTPRKT
1810 1820 1830 1840
SRSAKKTVAY NEDDDDDDND DRGWHGGGGR GAARRLNYST RSSNRR
Length:1,846
Mass (Da):206,759
Last modified:June 12, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE810C627DB8776A7
GO
Isoform 2 (identifier: A5HEI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-126: EYVTP → DLS

Note: Derived from EST data. No experimental confirmation available.Imported
Show »
Length:1,844
Mass (Da):206,484
Checksum:i62A195ED636A2129
GO
Isoform 3 (identifier: A5HEI1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-1692: Missing.

Note: No experimental confirmation available.Imported
Show »
Length:546
Mass (Da):61,354
Checksum:i0A19BD018424E7CC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC01753 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058980122 – 126EYVTP → DLS in isoform 2. 5
Alternative sequenceiVSP_058981393 – 1692Missing in isoform 3. Add BLAST1300

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
EF520004 mRNA Translation: ABQ12620.1
EU046617 mRNA Translation: ABS88747.1
AL391143 Genomic DNA Translation: CAC01753.1 Sequence problems.
CP002688 Genomic DNA Translation: AED92174.1
CP002688 Genomic DNA Translation: AED92175.1

Protein sequence database of the Protein Information Resource

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PIRi
T51532

NCBI Reference Sequences

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RefSeqi
NP_001190317.1, NM_001203388.1 [A5HEI1-2]
NP_197058.2, NM_121558.4 [A5HEI1-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
At.31788

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT5G15540.1; AT5G15540.1; AT5G15540 [A5HEI1-1]
AT5G15540.2; AT5G15540.2; AT5G15540 [A5HEI1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
831407

Gramene; a comparative resource for plants

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Gramenei
AT5G15540.1; AT5G15540.1; AT5G15540 [A5HEI1-1]
AT5G15540.2; AT5G15540.2; AT5G15540 [A5HEI1-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT5G15540

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Seed defective Arabidopsis mutants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF520004 mRNA Translation: ABQ12620.1
EU046617 mRNA Translation: ABS88747.1
AL391143 Genomic DNA Translation: CAC01753.1 Sequence problems.
CP002688 Genomic DNA Translation: AED92174.1
CP002688 Genomic DNA Translation: AED92175.1
PIRiT51532
RefSeqiNP_001190317.1, NM_001203388.1 [A5HEI1-2]
NP_197058.2, NM_121558.4 [A5HEI1-1]
UniGeneiAt.31788

3D structure databases

ProteinModelPortaliA5HEI1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G15540.1

PTM databases

iPTMnetiA5HEI1

Proteomic databases

PaxDbiA5HEI1
PRIDEiA5HEI1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G15540.1; AT5G15540.1; AT5G15540 [A5HEI1-1]
AT5G15540.2; AT5G15540.2; AT5G15540 [A5HEI1-2]
GeneIDi831407
GrameneiAT5G15540.1; AT5G15540.1; AT5G15540 [A5HEI1-1]
AT5G15540.2; AT5G15540.2; AT5G15540 [A5HEI1-2]
KEGGiath:AT5G15540

Organism-specific databases

AraportiAT5G15540
TAIRilocus:2180942 AT5G15540

Phylogenomic databases

eggNOGiKOG1020 Eukaryota
ENOG410XP32 LUCA
HOGENOMiHOG000276888
InParanoidiA5HEI1
KOiK06672
OMAiKQGLAHP
OrthoDBiEOG093600IF
PhylomeDBiA5HEI1

Enzyme and pathway databases

ReactomeiR-ATH-2470946 Cohesin Loading onto Chromatin

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A5HEI1

Gene expression databases

ExpressionAtlasiA5HEI1 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026003 Cohesin_HEAT
IPR024986 Nipped-B_C
IPR033031 SCC2/Nipped-B
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR21704 PTHR21704, 1 hit
PfamiView protein in Pfam
PF12765 Cohesin_HEAT, 1 hit
PF12830 Nipped-B_C, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCC2_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5HEI1
Secondary accession number(s): A7UDC4, F4K9U3, Q9LF28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: June 12, 2007
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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